Pharmacological activities of cinnamaldehyde and eugenol: antioxidant, cytotoxic and anti-leishmanial studies

Sharma, Upendra K.; Sharma, Ashish; Gupta, Ashutosh; Kumar, Ramesh; Pandey, Ashish; Pandey, Abhay K.

doi:10.14715/cmb/2017.63.6.15

Cited by 67 publications

(28 citation statements)

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“…Colares et al [46] and Le et al [47] proved the antileishmanial activity of eugenol and methyleugenol against promastigotes of L. amazonensis. Moreover, Charma et al [48] documented the antileishmanial effect of cinnamaldehyde and eugenol with IC 50 values of 0.681 and 1.426 g/ml, respectively. Eucalyptol and caryophyllene showed antitrypanosomal and antileishmanial activities, respectively [49].…”

Section: Discussionmentioning

confidence: 99%

Gas chromatography-mass spectrometry analysis, phytochemical screening and antiprotozoal effects of the methanolic Viola tricolor and acetonic Laurus nobilis extracts

Batiha

Beshbishy

Alkazmi

et al. 2020

BMC Complement Med Ther

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Background: The antiprotozoal and antioxidant activities of Viola tricolor and Laurus nobilis have been reported recently. Thus, the existing study pursued to assess the growth inhibition effect of methanolic extract of V. tricolor (MEVT) and acetonic extract of L. nobilis (AELN) against five Babesia parasites and Theileria equi in vitro and in vivo. Results: MEVT and AELN suppressed Babesia bovis, B. bigemina, B. divergens, B. caballi, and T. equi growth at halfmaximal inhibitory concentration (IC 50) values of 75.

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Section: Discussionmentioning

confidence: 99%

Gas chromatography-mass spectrometry analysis, phytochemical screening and antiprotozoal effects of the methanolic Viola tricolor and acetonic Laurus nobilis extracts

Batiha

Beshbishy

Alkazmi

et al. 2020

BMC Complement Med Ther

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“…Oxidative stress has been implicated in cell death [ 148 , 149 , 150 , 151 ]. Experimental facts support the treatment of transformed cells with HDACi, such as TSA, vorinostat, butyrate or MS275, leading to the accumulation of reactive oxygen species (ROS) inside cells that subsequently induce cell death [ 152 ].…”

Section: Mechanisms Of Action Of Hdacimentioning

confidence: 99%

Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy

2018

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Cancer initiation and progression are the result of genetic and/or epigenetic alterations. Acetylation-mediated histone/non-histone protein modification plays an important role in the epigenetic regulation of gene expression. Histone modification is controlled by the balance between histone acetyltransferase and (HAT) and histone deacetylase (HDAC) enzymes. Imbalance between the activities of these two enzymes is associated with various forms of cancer. Histone deacetylase inhibitors (HDACi) regulate the activity of HDACs and are being used in cancer treatment either alone or in combination with other chemotherapeutic drugs/radiotherapy. The Food and Drug Administration (FDA) has already approved four compounds, namely vorinostat, romidepsin, belinostat, and panobinostat, as HDACi for the treatment of cancer. Several other HDACi of natural and synthetic origin are under clinical trial for the evaluation of efficiency and side-effects. Natural compounds of plant, fungus, and actinomycetes origin, such as phenolics, polyketides, tetrapeptide, terpenoids, alkaloids, and hydoxamic acid, have been reported to show potential HDAC-inhibitory activity. Several HDACi of natural and dietary origin are butein, protocatechuic aldehyde, kaempferol (grapes, green tea, tomatoes, potatoes, and onions), resveratrol (grapes, red wine, blueberries and peanuts), sinapinic acid (wine and vinegar), diallyl disulfide (garlic), and zerumbone (ginger). HDACi exhibit their antitumor effect by the activation of cell cycle arrest, induction of apoptosis and autophagy, angiogenesis inhibition, increased reactive oxygen species generation causing oxidative stress, and mitotic cell death in cancer cells. This review summarizes the HDACs classification, their aberrant expression in cancerous tissue, structures, sources, and the anticancer mechanisms of HDACi, as well as HDACi that are either FDA-approved or under clinical trials.

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“…24 Em trabalhos independentes, Sharma (2017) e Lima (2017), e respectivos colaboradores, relataram a atividade contra leishmania do cinamaldeído e da vanilina. 25,26 Sendo a CI 50 do cinamaldeído de 1,426 g.mL -1 (10,79 x 10 3 μM) contra L. major. 25 Já a vanilina, na concentração de 50 μM, promoveu a inibição de 12,94% da forma amastigota de L. amazonesis.…”

Section: Síntese E Caracterização Das Hidrazonasunclassified

“…25,26 Sendo a CI 50 do cinamaldeído de 1,426 g.mL -1 (10,79 x 10 3 μM) contra L. major. 25 Já a vanilina, na concentração de 50 μM, promoveu a inibição de 12,94% da forma amastigota de L. amazonesis. 26 Estes dados, ao serem confrontados com os resultados obtidos no presente trabalho, indicam que a modificação molecular realizada promoveu um aumento da atividade antileishmania dos compostos testados, derivados do cinamaldeído e vanilina.…”

Section: Síntese E Caracterização Das Hidrazonasunclassified

Síntese, Atividade Antileshmania E Citotóxica De Hidrazonas Derivadas De Aldeídos Naturais

Souza¹,

Sousa²,

Cruz³

et al. 2019

Quím. Nova

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SYNTHESIS, ANTILESHMANIA AND CYTOTOXIC ACTIVITY OF HYDRAZONES FROM NATURAL ALDEHYDES. Leishmaniasis is endemic anthropozoonosis considered to be a severe public health problem. The treatment with pentavalent antimonials presents high toxicity motivating the search for effective and less toxic drugs. Hydrazones and N-acylhydrazones are functional groups that are prominent in Medicinal Chemistry, including as antiprotozoals. In this context, five hydrazones derived from the natural aldehydes were synthesized and the molecular structures were suitably determined to employ uni and bidimensional 1 H and 13 C NMR techniques. The antileishmanial activity of all hydrazones was determined against promastigote forms of Leishmania amazonensis, and the compounds HDZ-3, HDZ-4, and HDZ-5 showed the best results, with IC 50 of 9.00, 38.10 and 26.30 μM, respectively. In the cytotoxic evaluation against RAW macrophages, HDZ-4 presented the least cytotoxic (CC 50 = 222.24 μM) and the higher selectivity. Lipinski's descriptors of the hydrazones were calculated, and the compounds HDZ-3 and HDZ-5 were more promising. These hydrazones are hybrids of natural aldehydes with drugs, the first is the result of the junction of the cinnamaldehyde with isoniazid, and the second of the vanillin with hydralazine. The results highlighted the Markush isonicotinoylhydrazone and phthalazinylhydrazone groups, molecular structures that are present in HDZ-3 and HDZ-5 and are therefore considered innovators in the development of antileishmanial drugs.

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Pharmacological activities of cinnamaldehyde and eugenol: antioxidant, cytotoxic and anti-leishmanial studies

Cited by 67 publications

References 0 publications

Gas chromatography-mass spectrometry analysis, phytochemical screening and antiprotozoal effects of the methanolic Viola tricolor and acetonic Laurus nobilis extracts

Gas chromatography-mass spectrometry analysis, phytochemical screening and antiprotozoal effects of the methanolic Viola tricolor and acetonic Laurus nobilis extracts

Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy

Síntese, Atividade Antileshmania E Citotóxica De Hidrazonas Derivadas De Aldeídos Naturais

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