Effect of BCAA supplement timing on exercise-induced muscle soreness and damage: a pilot placebo-controlled double-blind study

Ra, Song‐Gyu; Miyazaki, Teruo; Kojima, Ryosuke; Komine, Shoichi; Ishikura, Keisuke; Kawanaka, Kentaro; Honda, Akira; Matsuzaki, Yasushi; Ohmori, Hitoshi

doi:10.23736/s0022-4707.17.07638-1

Cited by 33 publications

(36 citation statements)

References 33 publications

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“…Matsumoto, Koba, Hamada, Sakurai, Higuchi and Miyata 7 found that branched-chain amino acid supplementation results in a lower perceived muscle pain, fatigue, and muscle damage. Similar results were observed by Ra, Miyaza, et al 9 after an exercise protocol for induced muscle damage. In Mountain Bike athletes measured in an eight-day competition, Cathcart, Murgatroyd, McNab, Whyte and Easton 3 observed that the intake of a shake containing 80% of PRO and 20% of CHO results in better competitive performance and prevents muscle mass loss; however, there was no difference in comparison with the placebo for the muscle damage.…”

Section: Introductionsupporting

confidence: 90%

Hyperproteic supplementation attenuates muscle damage after simulated Olympic cross-country mountain biking competition: a randomized case-control study

Seccato

Bello

Queiroz

et al. 2019

Motriz: rev. educ. fis.

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We investigated the effect of high-protein (HI-PRO-70% protein and 30% carbohydrate) and highcarbohydrate supplementation (HI-CHO-70% carbohydrate and 30% protein) on muscle damage, haemoglobin, immune response, perceived pain and recovery post-simulated XCO. Methods: For this,10 amateur athletes (38±9.6 yrs.) were measured pre-, post-and 24-h post-trial. Results: In comparison to the pre-trial, the post-trial athletes presented leucocytosis (p≤0.001; 14.7±6.1 and 13.6±5.6 cells x10 3 ; for HI-PRO and HI-CHO, respectively) and neutropenia (p≤0.001; 11.9±5.2 and 10.7±4.9 cells x10 3 ; for HI-PRO and HI-CHO, respectively) but recovered at 24-h post-trial (Leukocytes: 6.9±1.4 and 7.1±1.4 cells x10 3 ; for HI-PRO and HI-CHO, respectively; neutrophils: 3.6±1.2 and 3.9±1.1 cells x103; for HI-PRO and HI-CHO, respectively) without a difference between conditions (p=0.808 and p=0.531; for leukocytes and neutrophils, respectively). A similar result was observed for perceived pain and recovery, where the condition did not interfere with these variables between the o measurement moments (p=0.245 and p=0.491; for pain and recovery respectively). There was an interaction effect for lactate dehydrogenase (LDH), where HI-PRO presented a lower serum concentration 24-h post-trial compared to HI-CHO (p=0.039; 181.3±21.9 and 201.0±10.4 IU/L; for HI-PRO and HI-CHO, respectively). Conclusion: HI-PRO supplementation results in better muscle damage recovery but only for LDH. Athletes should evaluate the cost-benefit of choosing the nutrients to be consumed immediately post-training or competition.

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Section: Introductionsupporting

confidence: 90%

Hyperproteic supplementation attenuates muscle damage after simulated Olympic cross-country mountain biking competition: a randomized case-control study

Seccato

Bello

Queiroz

et al. 2019

Motriz: rev. educ. fis.

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“…Thirdly, BCAAs are beneficial for treating cirrhosis by decreasing portal vein pressure and increasing mean artery pressure (96). Finally, BCAAs induce higher branched-chain α-keto acid dehydrogenase E1α expression levels in skeletal muscles, which facilitates BCAA metabolism in muscle tissue (97).…”

Section: Amino Acid Metabolism In Nafldmentioning

confidence: 99%

Abnormal metabolic processes involved in the pathogenesis of non‑alcoholic fatty liver disease (Review)

Shao

Qin

et al. 2020

Exp Ther Med

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Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and can lead to liver cirrhosis or liver cancer in severe cases. In recent years, the incidence of NAFLD has increased substantially. The trend has continued to increase and has become a key point of concern for health systems. NAFLD is often associated with metabolic abnormalities caused by increased visceral obesity, including insulin resistance, diabetes mellitus, hypertension, dyslipidemia, atherosclerosis and systemic microinflammation. Therefore, the pathophysiological mechanisms of NAFLD must be clarified to develop new drug treatment strategies. Recently, researchers have conducted numerous studies on the pathogenesis of NAFLD and have identified various important regulatory factors and potential molecular mechanisms, providing new targets and a theoretical basis for the treatment of NAFLD. However, the pathogenesis of NAFLD is extremely complex and involves the interrelationship and influence of multiple organs and systems. Therefore, the condition must be explored further. In the present review, the abnormal metabolic process, including glucose, lipid, amino acid, bile acid and iron metabolism are reviewed. It was concluded that NAFLD is associated with an imbalanced metabolic network that involves glucose, lipids, amino acids, bile acids and iron, and lipid metabolism is the core metabolic process. The current study aimed to provide evidence and hypotheses for research and clinical treatment of NAFLD.

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“…Accumulating data suggest that BCAA supplementation before exercise may exert positive effects of BCAA on muscle soreness and low-to-moderate exercise-induced damage in some population groups [67,68], but it remains controversial and unclear due to the small amount of studies included in systematic reviews and meta-analysis. A recent meta-analysis including eight studies with a relatively small number of participants (ranges between 12–28 subjects included in each) indicated that use of BCAAs might be better than passive recovery after various exercise types in athletes [69].…”

Section: Protein and Amino Acid Supplements Targeted For Better Atmentioning

confidence: 99%

Protein Supplements and Their Relation with Nutrition, Microbiota Composition and Health: Is More Protein Always Better for Sportspeople?

et al. 2019

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Sports nutrition products are developed and targeted mainly for athletes to improve their nutrient intake, performance, and muscle growth. The fastest growing consumer groups for these products are recreational sportspeople and lifestyle users. Although athletes may have elevated physiological protein requirements and they may benefit from dietary supplements, the evidence regarding the role of dietary protein and supplements in the nutrition of recreational sportspeople and sedentary populations is somewhat complex and contradictory. In high-protein diets, more undigested protein-derived constituents end up in the large intestine compared to moderate or low-protein diets, and hence, more bacterial amino acid metabolism takes place in the colon, having both positive and negative systemic and metabolic effects on the host. The aim of the present review is to summarize the impact of the high-protein products and diets on nutrition and health, in sportspeople and in sedentary consumers. We are opening the debate about the current protein intake recommendations, with an emphasis on evidence-based effects on intestinal microbiota and personalized guidelines regarding protein and amino acid supplementation in sportspeople and lifestyle consumers.

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Effect of BCAA supplement timing on exercise-induced muscle soreness and damage: a pilot placebo-controlled double-blind study

Cited by 33 publications

References 33 publications

Hyperproteic supplementation attenuates muscle damage after simulated Olympic cross-country mountain biking competition: a randomized case-control study

Hyperproteic supplementation attenuates muscle damage after simulated Olympic cross-country mountain biking competition: a randomized case-control study

Abnormal metabolic processes involved in the pathogenesis of non‑alcoholic fatty liver disease (Review)

Protein Supplements and Their Relation with Nutrition, Microbiota Composition and Health: Is More Protein Always Better for Sportspeople?

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