Prevalence and severity of syndrome Z in women with metabolic syndrome on waiting list for bariatric surgery: a cross-sectional study

Perez, Eduardo Araújo; Oliveira, Luís Vicente Franco de; Freitas, Wilson Rodrigues de; Malheiros, Carlos Alberto; Ilias, Elias Jirjoss; Silva, Anderson Soares; Urbano, Jéssica Julioti; Oliveira, Patricia; Cepeda, Felipe X.; Sampaio, Luciana Maria Malosá; Trombetta, Ivani C.; Dellê, Humberto; Neto, Daniel Gianella; Nacif, Sérgio Roberto; Stirbulov, Roberto

doi:10.1186/s13098-017-0269-2

Cited by 7 publications

(6 citation statements)

References 51 publications

(44 reference statements)

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“…enrolled 83 female patients with metabolic syndrome, and they also found a high prevalence of syndrome Z (75.8%) in these patients. [11]…”

Section: Discussionmentioning

confidence: 99%

“…in their study observed that the mean FBS in subjects without OSA was 99.8 mg/dL, while the mean FBS levels in patients with mild, moderate, and severe OSA were 117.6, 139.7, and 142.3 mg/dL, respectively; the differences were statistically significant ( P < 0.001). [11] Aronsohn et al . showed that increasing severity of OSA was associated with poorer glucose control.…”

Section: Discussionmentioning

confidence: 99%

“…[9] Similar results were found in studies conducted by Perez et al . [11] and Walia et al . [23], suggesting a strong association between severe OSA and resistant elevated BP.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of obstructive sleep apnea in metabolic syndrome

Soin

Kumar

Chahal

et al. 2019

J Family Med Prim Care

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Background: Metabolic syndrome has become one of the most important public health problems with a growing prevalence in both developed and developing countries. Obesity is a major risk factor for obstructive sleep apnea (OSA), which is associated with significant cardiorespiratory morbidity. Aims: The aims of this study were to find out the prevalence of OSA in patients with metabolic syndrome and to highlight the importance of assessment of OSA in these patients. Methods: This cross-sectional analytical study was conducted on 100 subjects aged 30–60 years, comprising 50 cases of metabolic syndrome and 50 controls without metabolic syndrome. Overnight polysomnography was done in all the subjects. Prevalence and severity of OSA were assessed and compared between the two groups. Results: Prevalence of OSA was significantly higher (66%) in patients with metabolic syndrome than in subjects without metabolic syndrome (12%). Out of 33 (66%) OSA patients with metabolic syndrome, 8 (16%) had mild OSA, 11 (22%) had moderate OSA, and 14 (28%) had severe OSA. Increasing severity of OSA was associated with higher mean levels of all the metabolic syndrome parameters except serum high density lipoprotein (HDL). Conclusions: OSA is highly prevalent in patients with metabolic syndrome. Also, the increasing severity of OSA is associated with poorer control of diabetes, hypertension, and dyslipidemia, which are all components of metabolic syndrome. Therefore, effective treatment of metabolic syndrome can prevent and control OSA in these patients. Similarly, reducing the severity of OSA (by early diagnosis and treatment) in patients with metabolic syndrome might help to optimize control of blood sugar, blood pressure, and serum lipids, thereby reducing the risk of cardiovascular disease. Therefore, the need for screening metabolic syndrome patients for OSA has been reinforced by this study.

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“…enrolled 83 female patients with metabolic syndrome, and they also found a high prevalence of syndrome Z (75.8%) in these patients. [11]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of obstructive sleep apnea in metabolic syndrome

Soin

Kumar

Chahal

et al. 2019

J Family Med Prim Care

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“…The recruitment was based on sample size calculation, based on a previous study by Perez et al (2017 ), which focused on the levels of TNF-α of obese patients before and after bariatric surgery. Considering an error of 0.05 and a significance level of 95%, the total sample size to detect an effect of 0.88 was 24.…”

Section: Methodsmentioning

confidence: 99%

Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women

Silva-Reis

Brandão-Rangel²,

Moraes-Ferreira³

et al. 2022

Front. Physiol.

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Background: Obesity impairs lung function and mechanics and leads to low-grade inflammation, but the effects of combined physical exercise (CPE) on that are unknown.Methods: We investigated the effects of 12 weeks of combined physical exercise (aerobic + resistance training), in non-obese (n = 12), overweight (n = 17), and obese grade I (n = 11) women. Lung function and lung mechanics were evaluated. The systemic immune response was evaluated by whole blood analysis and biomarker measurements, while pulmonary fibrotic biomarkers were evaluated in the breath condensate.Result: CPE improved forced vital capacity (FVC) % (p < 0.001) and peak expiratory flow (PEF) % (p < 0.0003) in the obese group; resistance of the respiratory system (R5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; resistance of proximal airways (R20Hz) in non-obese (p < 0.01), overweight (p < 0.0009), and obese (p < 0.0001) groups; resistance of distal airways (R5Hz–R20Hz) in non-obese (p < 0.01), overweight (p < 0.0012), and obese (p < 0.0001) groups; reactance of the respiratory system (X5Hz) in non-obese (p < 0.01), overweight (p < 0.0006), and obese (p < 0.0005) groups; impedance of the respiratory system (Z5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; central resistance (RCentral) in non-obese (p < 0.01), overweight (p < 0.001), and obese (p < 0.0003) groups; and the peripheral resistance (RPeripheral) in non-obese (p < 0.03), overweight (p < 0.001), and obese (p < 0.0002) groups. CPE reduced the pro-fibrotic IGF-1 levels in BC in overweight (p < 0.0094) and obese groups (p < 0.0001) and increased anti-fibrotic Klotho levels in BC in obese (p < 0.0001) groups, and reduced levels of exhaled nitric oxide in overweight (p < 0.03) and obese (p < 0.0001) groups.Conclusion: CPE improves lung function, mechanics, and pulmonary immune response in overweight and obese grade I women by increasing anti-fibrotic protein Klotho and reducing pro-fibrotic IGF-1.

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“…6 Association was found between OSAS and metabolic syndrome (MetS) and the continuing increase in the prevalence of OSAS worldwide is nearly followed by increased number of MetS. [7][8][9] This study investigated the prevalence and severity of syndrome Z at tertiary care center. Table 2 shows that 60.0% participants were belonged to severe grade of OSAS and 27.5 were moderate and 7.5% were mild grade of OSAS classification respectively.…”

Section: Introductionmentioning

confidence: 99%

The prevalence of syndrome Z (the interaction of obstructive sleep apnoea with the metabolic syndrome) in a tertiary care center, Gujarat, India

Sureja¹,

Bhambhani²

2018

Int J Adv Med

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Background: The interaction of obstructive sleep apnoea (OSA) with vascular risk factors is known as syndrome Z which is also known as the metabolic syndrome or the insulin resistance syndrome and these include the hypertension, central obesity, insulin resistance and hyperlipidaemia. The objective of the present study was to investigate the prevalence and severity of syndrome Z at tertiary care center.Methods: This prospective study was conducted among 40 eligible patients between May and July 2018 at the tertiary care center included adult patients >18years of age. Overnight fasting glucose and lipid levels were measured, and baseline anthropometric data recorded. All sleep studies were scored and reported by a sleep physician. OSA was deemed to be present if the respiratory disturbance index (RDI) was >5, with mild, moderate and severe categories classified according to the Chicago criteria.Results: Mean age of participants was 52.7years, 77.5% were male, Mean BMI and waist circumference were 29.2kg/m2 and 113.8cm respectively. Almost 92.5% participants were known case of HTN, 85.0% were DM and 67.5% Dyslipidemia. Around 60.0% participants were belonged to severe grade of OSAS and 7 (17.5%) patients who fulfilled all five criteria for the diagnosis of the metabolic syndrome had severe OSAS. The prevalence of OSA in the entire group was 95.0%.Conclusions: The prevalence of syndrome Z in present study participants was very high. With the help of history and polysomnogram, metabolic syndrome should be screened for OSA. Early diagnosis and treatment of OSA is the essential part in the treatment of metabolic syndrome and hence CAD.

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Prevalence and severity of syndrome Z in women with metabolic syndrome on waiting list for bariatric surgery: a cross-sectional study

Cited by 7 publications

References 51 publications

Evaluation of obstructive sleep apnea in metabolic syndrome

Evaluation of obstructive sleep apnea in metabolic syndrome

Combined resistance and aerobic training improves lung function and mechanics and fibrotic biomarkers in overweight and obese women

The prevalence of syndrome Z (the interaction of obstructive sleep apnoea with the metabolic syndrome) in a tertiary care center, Gujarat, India

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