“…13 The aggregated MAVS acts as a central platform for the recruitment of downstream signaling components, including TRAF2/3/5/6, TBK1 and IKK, leading to the activation of the transcription factors IRF3 and NF-κB and to the induction of downstream antiviral effector genes. [14][15][16][17] SARS-CoV-2, a member of the coronavirus family, is a typical single-stranded positive-sense RNA virus that encodes over 28 proteins, including 4 structural proteins (spike, membrane, envelope, and nucleocapsid), 16 nonstructural proteins (NSP1-NSP16), and 8 auxiliary proteins (ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b and ORF14). [18][19][20] Recently, SARS-CoV-2 has caused a global pandemic and worldwide social and economic disruption.…”