Role of inducible nitric oxide synthase and interleukin-6 expression in estimation of skin burn age and vitality

El-Noor, Mona Mohamed Abo; Elgazzar, Fatma; Alshenawy, Hanan AlSaeid

doi:10.1016/j.jflm.2017.09.001

Cited by 17 publications

(10 citation statements)

References 26 publications

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“…El-Noor et al (61) studied the expression of inducible nitric oxide synthase (iNOS) and IL-6 in burned rat skin samples. The authors caused burns on the skin of the mice, sampling them after a defined time (1, 3, 5, 7, 9, 11, 13, 15, and 21 days after the burn).…”

Section: Discussionmentioning

confidence: 99%

The Role of miRNAs as New Molecular Biomarkers for Dating the Age of Wound Production: A Systematic Review

et al. 2022

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Background:The timing of wounds production is a significant issue in forensic pathology. Although various methods have been evaluated, obtaining an accurate dating of lesions is still a challenge. The pathologist uses many parameters to value wound age, such as histological and immunohistochemical. In recent years, there have been many studies regarding the use of miRNAs in wound-age estimation; indeed, miRNAs have multiple potential uses in forensic pathology.Scope:This review aims to verify the efficacy and feasibility of miRNAs as a tool for determining the timing of lesions.Materials and Methods:The authors conducted the systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. PubMed was used as a search engine to find articles published between January, 1st 2016 and October, 1st 2021, to evaluate the current state of the art regarding wound-age estimation.Results:A total of 256 articles were collected; after screening according to PRISMA guidelines, the systematic review included 8 articles. The studies included in this review were all Original articles evaluating the use of biomarkers for wound-age determination.Discussion and Conclusion:The literature review showed that analysis of miRNA is an innovative field of study with significant potentiality in forensic pathology. There are few studies, and almost all of them are at an early stage. The challenge is to understand how to standardize the samples' selection to obtain reliable experimental data. This observation represents a necessary prerequisite to planning further clinical trials.

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Section: Discussionmentioning

confidence: 99%

The Role of miRNAs as New Molecular Biomarkers for Dating the Age of Wound Production: A Systematic Review

et al. 2022

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“…Low IL-6 levels were found in patients with IgA nephropathy [41]. Moreover, IL-6 is putatively involved both in skin burns [42] and excisional wound healing [43, 44]. In both cases, higher IL-6 levels at initial healing stages were associated with better outcomes.…”

Section: Discussionmentioning

confidence: 99%

Topical essential fatty acid oil on wounds: Local and systemic effects

et al. 2019

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BackgroundThe use of medicinal plants and their derivatives is increasing, and approximately one-third of all traditional herbal medicines are intended for wound treatment. Natural products used in these treatments include vegetable oils, which are rich in essential fatty acids. Once in contact with an ulcerative surface, the oil reaches the blood and lymphatic vessels, thus eliciting systemic effects.ObjectiveThis study evaluated the local and possible systemic effects of essential fatty acids (sunflower oil) applied topically to rat wounds.MethodsCutaneous punch wounds (6 mm) were produced on the dorsa of 30 rats. Saline (SS), mineral oil (MO) or essential fatty acid (EFA) solutions were applied topically. Healing was evaluated after 2, 4 and 10 days (n = 5 per group) by visual and histological/morphometric examination, second harmonic generation (SHG) microscopy, and cytokine and growth factor quantification in the scar tissue (real-time PCR) and in serum (ELISA).ResultsMO/EFA-treated animals had higher IGF-1, leptin, IL-6 and IFN-γ mRNA expression and lower serum IL-6 levels than the control (SS/MO) animals. SHG analysis showed no difference in collagen density between the animals treated with MO and EFA.ConclusionEFA treatment induces topical (observed by local IGF-1, leptin, IL-6 and IFN-γ production) and systemic effects, lowering IL-6 levels in the serum. As the oil is widely used to shorten ulcer healing time, studies are needed to evaluate the treatment safety and possible undesired effects.

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“…• Blood immune cell count (5) (Avsar et al 2016;Fear et al 2016;Khalid et al 2019;Lee et al 2011;Marano et al 1988;Silva et al 2013;Valvis et al 2015;Weaver et al 2020;Zakirova et al 2021) Basophils (Weaver et al 2020) Undefined cells (Abo El-Noor et al 2017;Daniel et al 2007;Fear et al 2016;Ibrahim et al 2014;Iwashita et al 1999;Mikhal'chik et al 2004;Rani et al 2014;Schwacha et Groger et al 2010;Madibally et al 2003;Madihally et al 2002;Madihally et al 2001;Rani et al 2014;Takahashi et al 2004) J o u r n a l P r e -p r o o f J o u r n a l P r e -p r o o f 1…”

Section: Eosinophilsmentioning

confidence: 99%

“…Baseline-controlled studies that were used for risk of bias assessment (Abdallah Hajj Hussein et al 2012;Abo El-Noor et al 2017;Begieneman et al 2012;Bohannon et al 2008;Bohr et al 2013;Bohr et al 2012;Chakraborty et al 2018; Chao et al…”

Section: Subgroup Analysismentioning

confidence: 99%

Burn-Induced Local and Systemic Immune Response: Systematic Review and Meta-Analysis of Animal Studies

Mulder

Koenen

Vlig

et al. 2022

Journal of Investigative Dermatology

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Role of inducible nitric oxide synthase and interleukin-6 expression in estimation of skin burn age and vitality

Cited by 17 publications

References 26 publications

The Role of miRNAs as New Molecular Biomarkers for Dating the Age of Wound Production: A Systematic Review

The Role of miRNAs as New Molecular Biomarkers for Dating the Age of Wound Production: A Systematic Review

Topical essential fatty acid oil on wounds: Local and systemic effects

Burn-Induced Local and Systemic Immune Response: Systematic Review and Meta-Analysis of Animal Studies

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