Relationship between serum 25-hydroxy vitamin D levels and retinopathy of prematurity

Kabataş, Emrah Utku; Dinlen, Nurdan; Zencıroğlu, Ayşegül; Díllí, Dílek; Beken, Serdar; Okumuş, Nurullah

doi:10.1177/0036933017701867

Cited by 12 publications

(7 citation statements)

References 27 publications

(61 reference statements)

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“…Several serum/plasma factors including VEGF, 145,163,198,223,300,303,427 bilirubin, 96,113,134,169,178,201,258,416 sE-selectin, 66,304 CRP, 186 apelin, 16 vitamin D, 194 trace elements such as zinc, 407 and inflammatory cytokines such as IL-6 350 have been studied. Although VEGF is a key factor in retinal angiogenesis, studies on systemic levels of VEGF and related factors such as soluble VEGF receptors showed contradictory results.…”

Section: Alternative Risk Factorsmentioning

confidence: 99%

Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

395

337

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Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventions, comorbidities of prematurity, nutrition, and genetic factors. We review the existing literature addressing various possible ROP risk factors. Although there have been contradictory reports, and the risk may vary between different populations, understanding ROP risk factors is essential to develop predictive models, to gain insights into pathophysiology of retinal vascular diseases and diseases of prematurity, and to determine future directions in management of and research in ROP.

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Section: Alternative Risk Factorsmentioning

confidence: 99%

Retinopathy of prematurity: a review of risk factors and their clinical significance

Kim

Port

Swan

et al. 2018

Survey of Ophthalmology

395

337

View full text Add to dashboard Cite

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“…The study selection process and exclusion criteria are described in Fig 1. Of the 128 studies identified initially, 120 were excluded based on review of the title, abstract or full text. The reasons for excluding 17 studies [33,34,[46][47][48][49][50][51][52][53][54][55][56][57][58][59][60] after full-text review, are provided in Fig 1. The remaining eight studies met the inclusion criteria and were included in the meta-analysis [35,37,38,40,41,43,61,62].…”

Section: Literature Search and Study Selectionmentioning

confidence: 99%

Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis

et al. 2020

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Neonatal vitamin D deficiency is common and is associated with development of pulmonary disease in children and adults. While the role of vitamin D in normal lung development is well established, the association between vitamin D deficiency and bronchopulmonary dysplasia (BPD) remains unclear. The present meta-analysis was conducted to evaluate the relationship between vitamin D and BPD. We identified relevant studies (n = 8) using the PubMed, EMBASE, Cochrane Library, and KoreaMed databases and applied the Newcastle-Ottawa Scale to assess the methodological components of each study, and used I 2 statistic to evaluate heterogeneity. Comprehensive Meta-Analysis software version 3.3 was used for the statistical analysis. A total of 909 infants were included, of whom 251 (27.6%) were diagnosed with BPD. We found that both vitamin D deficiency at birth (four studies; OR 2.405; 95% CI 1.269 to 4.560; p = 0.007) and low levels of vitamin D at birth (four studies; standardized mean difference-1.463; 95% CI-2.900 to-0.027; p = 0.046) were associated with BPD. The compiled data suggest that antenatal vitamin D deficiency and low vitamin D levels are associated with neonatal BPD.

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“…Due to the lack of a similar study and according to Kabataş et al 14 who reported the vitamin D level in infants with RoP who needed or did not need treatment at 7.1 ± 5.2 ng/dL and 11.9 ± 6.5 ng/dL, respectively, using the student t test with α = 0.01 and β = 0.1, the sample size in each group was calculated as 46 infants. However, considering the probable dropout, the final sample size was adjusted to 56 infants in each group.…”

Section: Methodsmentioning

confidence: 99%

“…13 Low serum levels of 25-hydroxy vitamin D on the first day of life have been proposed as a potential risk factor for retinopathy of immaturity, and hence, treatment of immature neonates is necessary. 14 Expression of vitamin D receptor has been shown to play an important role in the evolution of retinal vessels, especially during the final steps of retinal vascularization. Although pathologic retinal neovascularization during oxygen-therapy induced ischemic retinopathy is independent of the expression of vitamin D receptor, the inhibition of retinal neovascularization through 1,25 hydroxy vitamin D3 depends on the expression of vitamin D receptor.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Vitamin D Levels in Premature Infants with and without Retinopathy of Prematurity

et al. 2022

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Background: Retinopathy of prematurity (RoP) is a cause of newborn blindness. Several predisposing factors have been reported to contribute to the disease process. The current study aimed to compare serum vitamin D levels in infants with and without RoP. Methods: This case-control study was conducted on 154 very low birth weight (VLBW) infants admitted to Ghaem hospital, Mashhad, Iran, during 2016–2019. Retinal examination for RoP was done at the 32nd week of pregnancy and vitamin D level was determined using the infants’ first-day serum samples. A researcher-made questionnaire including maternal, infant, laboratory, and retinal examination information was used as the data collection tool. Results: Out of 154 infants in the study, 56 (36.4%) were normal while 98 (63.6%) had RoP. Based on the severity of retinopathy, 43 infants (43.9%) were at stage I, 48 (49%) at stage II, and 7 (7.1%) at stage III. Significant differences in neonatal (P<0.001) and maternal (P=0.015) vitamin D levels, first and fifth minute Apgar scores (P=0.034 and P=0.001, respectively), and weight (P=0.014) were found between the infants with and without RoP. Conclusion: The incidence of RoP was higher in infants with lower gestational age, lower birth weight, low first and fifth minutes Apgar scores, and male sex. Low serum levels of vitamin D in premature infants and their mothers were associated with incidence of RoP. The higher the stage of RoP, the greater was the severity of vitamin D deficiency. Thus, controlling the maternal vitamin D level during pregnancy, consumption of vitamin D supplements, and investigation of serum vitamin D levels in premature infants are recommended. Early correction of vitamin D deficiency may lead to reduction of RoP.

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Relationship between serum 25-hydroxy vitamin D levels and retinopathy of prematurity

Cited by 12 publications

References 27 publications

Retinopathy of prematurity: a review of risk factors and their clinical significance

Retinopathy of prematurity: a review of risk factors and their clinical significance

Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis

Comparison of Vitamin D Levels in Premature Infants with and without Retinopathy of Prematurity

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