Effect of conventional and LED phototherapy on the antioxidant-oxidant status in preterm neonates with jaundice

Allam, Anusha; Ravikiran, S. R.; Baliga, B. Shantharam; Bhat, Kamalakshi G.; Joseph, Nitin

doi:10.1007/s13312-017-1127-x

Cited by 10 publications

(7 citation statements)

References 8 publications

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“…Interesting study done exclusively among preterm neonates, compared antioxidant-oxidant parameters following conventional and LED phototherapy, both conventional and LED phototherapy resulted in increased oxidative stress index. However, derangement of antioxidant-oxidant parameters was more pronounced after conventional as compared to LED phototherapy [13] . Unconjugated bilirubin is considered a potent antioxidant when present at moderate levels.…”

Section: Discussionmentioning

confidence: 89%

The Effect of Phototherapy on Apaptosisin Hyperbilirubinemic Preterm Neonates

2020

IJPHRD

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Objective: This study aimed to assess the impact of hyperbilirubinemia and Intensive phototherapy on apaptosis in peripheral blood of preterm infants. Patients and Method:The study was conducted on 18 preterm infants with non-hemolytic hyperbilirubinemia and 9 control healthy preterm infants. Apaptosismarkers (anti-apoptotic protein Bcl2, and pro-apoptotic protein BAX) was assessed using ELISA technique. Blood samples wereobtained at enrollment in all infants and after24 hours of exposure to intensive phototherapy in jaundiced infants.Result: Before phototherapy, no significant difference in the serum levels of bcl2 and Bax protein between jaundiced and non-jaundiced preterm infants (P = 0.570, p= 0.329 respectively), After phototherapy The serum levels of Bcl2 decrease while The serum levels of BAX increased significantly (P=0.003, p<0.001 respectively). Conclusion:Hyperbilirubinemia does not influence apaptosis whereas intensive phototherapy do in preterm infants with hyperbilirubinemia.

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Section: Discussionmentioning

confidence: 89%

The Effect of Phototherapy on Apaptosisin Hyperbilirubinemic Preterm Neonates

2020

IJPHRD

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“…9,19 It has been shown in some studies that after phototherapy, their ability to fight increased and oxidative stress is weakened by reducing the levels of antioxidants such as glutathione and ascorbic acid. [20][21][22] Dynamic thiol-disulfide homeostasis in newborns has an important role in many oxidant-antioxidant mechanisms such as detoxification, antioxidant protection, regulation of enzyme activity. 23 Thiol-disulfide homeostasis has been associated with diseases that increased inflammation such as neonatal sepsis and hepatitis, and conditions that increase stress such as hyperbilirubinemia.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of thiol–disulfide homeostasis and oxidative stress parameters in newborns receiving phototherapy

Demirtas

Erdal

2023

Journal of Investigative Medicine

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The aim of our study was to evaluate oxidative stress and thiol–disulfide homeostasis in term newborns receiving phototherapy. The study was planned as a single-blind, intervention study in a single center with level 3 neonatal intensive care unit to investigate the effect of phototherapy on the oxidative system in term newborns with hyperbilirubinemia. Neonates with hyperbilirubinemia were treated with total body exposure phototherapy technique for 18 h using a Novos® device. Blood samples of 28 term newborns were taken before and after phototherapy. Total and native thiol, total antioxidant status (TAS) and total oxidant status (TOS), and oxidative stress index (OSI) levels were measured. The 28 newborn patients included 15 (54%) males and 13 (46%) females with a mean birthweight of 3080.1 ± 366.5 g. Native and total thiol levels were found to be decreased in patients receiving phototherapy (p = 0.021, p = 0.010). Besides, significantly lower TAS and TOS levels were found after phototherapy (p < 0.001, p < 0.001). We found that decreased thiol levels were related to increased oxidative stress. We also determined significantly the lower bilirubin levels after phototherapy (p < 0.001). In conclusion, we found that phototherapy treatment induced decreased oxidative stress associated with hyperbilirubinemia in neonates. Thiol–disulfide homeostasis can be used as a marker of oxidative stress due to hyperbilirubinemia in the early period.

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“…Meanwhile, Kale et al 12 found that both conventional phototherapy with blue fluorescent lights and intensive LED phototherapy significantly decreased serum TAC and increased OSI values. Allam et al 15 demonstrated that both conventional and LED phototherapy resulted in increased OSI values; however, alteration of antioxidant/oxidant parameters was more pronounced after conventional than after LED phototherapy. Another study reported increased oxidative stress following conventional phototherapy, but found no significant change following LED phototherapy.…”

Section: Discussionmentioning

confidence: 99%

“…8 However, some reports have indicated that phototherapy may cause oxidative stress, lipid peroxidation, and DNA damage. [9][10][11][12][13][14][15] The Turkish Journal of Pediatrics • September-October 2019 Moreover, neonates have a limited antioxidant protective capacity, and oxidative damage has an important role in the pathogenesis of many diseases in the newborn period. 16 Therefore, this study aimed to assess the impacts of conventional and LED phototherapy on DNA damage, total oxidant status (TOS), and total antioxidant capacity (TAC) in jaundiced newborns.…”

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confidence: 99%

Impacts of phototherapy on DNA damage and total oxidant/ antioxidant status in jaundiced newborns

Bulut

Duruyen

2019

Turk J Pediatr

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Jaundice is common in newborn babies, and pathologic hyperbilirubinemia is frequently treated with phototherapy. Although it is considered to be safe, the side effects of phototherapy in newborns are still a matter of debate. In this study, the impacts of two types of phototherapy, conventional fluorescence and intensive light-emitting diodes (LED), on DNA damage and total oxidant/ antioxidant status in jaundiced newborns were assessed. The study group included 40 newborns (gestation age ≥ 37 weeks) on days 2-8 after birth. Newborns were divided into two groups on the basis of need for phototherapy: 20 newborns were exposed to conventional phototherapy (Group I); and 20 infants were exposed to intensive phototherapy (Group II). Blood samples were taken from all infants at admission and after phototherapy to determine plasma 8-hydroxy-2-deoxy-guanosine (8-OH-dG; a marker of DNA damage), total oxidant status (TOS), and total antioxidant capacity (TAC). The oxidative stress index (OSI) was also calculated. Demographic information was recorded, and DNA damage, TOS, and TAC were compared. There were no differences in demographic information between the two groups. There were no significant differences in DNA damage, TOS, TAC, and OSI between Groups I and II before phototherapy (p > 0.05) and no significant differences in DNA damage, TOS, TAC, and OSI between the two groups after phototherapy (p > 0.05). However, the TAC decreased significantly in both groups after phototherapy (p < 0.01). These findings suggest that conventional and intensive phototherapies do not affect DNA damage and oxidative stress, supporting the safety of its use as the preferred treatment for jaundiced newborns.

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Effect of conventional and LED phototherapy on the antioxidant-oxidant status in preterm neonates with jaundice

Abstract: Both modes increased oxidative stress index; however, conventional phototherapy resulted in higher oxidative stress.

Cited by 10 publications

References 8 publications

The Effect of Phototherapy on Apaptosisin Hyperbilirubinemic Preterm Neonates

The Effect of Phototherapy on Apaptosisin Hyperbilirubinemic Preterm Neonates

Evaluation of thiol–disulfide homeostasis and oxidative stress parameters in newborns receiving phototherapy

Impacts of phototherapy on DNA damage and total oxidant/ antioxidant status in jaundiced newborns

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