Atraumatic segmental atypical femur fracture secondary to bisphosphonate use: A case report

Lovy, Andrew J.; Patterson, Diana C.; Skeeles, Laura; Ghillani, Richard; Joseph, David B.; Wu, Yangguan; Hasija, Rohit

doi:10.1016/j.jcot.2017.03.005

Cited by 3 publications

(2 citation statements)

References 25 publications

(20 reference statements)

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“…AFF is a rare type of femoral stress fracture potentially associated with prolonged use of bisphosphonates [8]. The risk factors for AFF include long-term bisphosphonate use, high body mass index, proton pump inhibitor or glucocorticoid use, genu-varum, bowed femur, Lovy et al reported an atypical femur fracture treated by cephalomedullary nailing with segmental fracture pattern [13]. They reported that the patient had over one year of use of bisphosphonates without any other atypical femur fracture risk factors.…”

Section: Discussionmentioning

confidence: 99%

Fractures in Corticosteroid- and Bisphosphonate-treated Subjects With Longstanding Rheumatoid Arthritis

Moghtadaie¹,

Yazdi²,

Salimzadeh³

2021

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Background: Bisphosphonates are the most widely prescribed agents for the treatment of postmenopausal osteoporosis and other metabolic bone diseases. Atypical femoral fractures in bisphosphonate-treated patients have raised concerns regarding the long-term safety of this class of medications. Case Presentation: In this study, we report two patients suffering from fractures while receiving biphosphonates; a postmenopausal patient with rheumatoid arthritis and a history of long-term use of bisphosphonates and glucocorticoids presenting with multiple fractures as case one and another 52-year-old female patient diagnosed with Systemic Lupus Erythematosus (SLE) who suffered from a femoral shaft fracture without any history of prior traumatic incidents as case two. Conclusions: Considering the low risk for atypical femoral fractures, further careful screening for these types of fractures should be undertaken. In addition, in order to lower the rate of fractures in patients on long-term bisphosphonate therapy, assessment of patients’ contralateral side should be considered to prevent further fractures, especially in patients with prodromal pain.

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Section: Discussionmentioning

confidence: 99%

Fractures in Corticosteroid- and Bisphosphonate-treated Subjects With Longstanding Rheumatoid Arthritis

Moghtadaie¹,

Yazdi²,

Salimzadeh³

2021

crcp

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“…They are stress fractures that originate in the lateral part of the femoral shaft after minimal to no trauma [1]. Since 2006, several case reports of bisphosphonate-associated atypical femur fractures started to come into sight [8,9]. Several criteria both minor and major that help defines this type of fracture were established by the American Society for Bone and Mineral Research [7].…”

Section: Introductionmentioning

confidence: 99%

Untreated Atypical Left Femoral Shaft Fracture: A Case Report of Its Complication

et al. 2023

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Background: Bisphosphonate therapy is used to manage osteoporosis and decrease the risk of vertebral and hip fractures. These drugs act by suppressing osteoclast activity by inducing the inhibition of bone resorption and increasing bone mineral density. It has been shown that long-term use of bisphosphonate is correlated to a higher incidence of atypical femoral fractures. Case report: This is a case report of an 81-year-old female, on bisphosphonate therapy for 12 years and with chronic left thigh pain for two and a half years who developed an incomplete atypical left femur fracture. What’s special about this case is that the fracture was ignored and then progressed after three months into a complete displaced spiral fracture that required surgical fixation. Conclusion: The benefits of bisphosphonate treatment in preventing osteoporotic fractures outweigh the risk of the occurrence of these atypical fractures. Orthopedic surgeons as well as primary care physicians must keep atypical fractures in their differential diagnosis in patients presenting with prodromal symptoms and who are on long-term bisphosphonate therapy

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Ibandronic-acid

2017

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Atraumatic segmental atypical femur fracture secondary to bisphosphonate use: A case report

Cited by 3 publications

References 25 publications

Fractures in Corticosteroid- and Bisphosphonate-treated Subjects With Longstanding Rheumatoid Arthritis

Fractures in Corticosteroid- and Bisphosphonate-treated Subjects With Longstanding Rheumatoid Arthritis

Untreated Atypical Left Femoral Shaft Fracture: A Case Report of Its Complication

Ibandronic-acid

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