Extraction, isolation and characterization of bioactive compounds from chloroform extract of Carica papaya seed and it's in vivo antibacterial potentiality in Channa punctatus against Klebsiella PKBSG14

Ghosh, S. K.; Saha, Mandira; Bandyopadhyay, Probir K.; Jana, Monoranjan

doi:10.1016/j.micpath.2017.08.033

Cited by 18 publications

(4 citation statements)

References 20 publications

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“…Moreover, Indian papaya seed contained 14 metabolic compounds, including oleic acid, stearic acid, methyl ester, dibenzoyl-L-tartaric acid, palmitic acid, and phenol, 2-methoxy-5-prophenyl-(E) [ 49 ]. Ghosh et al [ 50 ] also identified oleic acid as the main compound in PLs. They also found certain secondary metabolites in PLs such as caffeine, cinnamic, chlorogenic, quinic, p -coumaric, vanillic, and protocatechuic acids, as well as naringenin, hesperidin, rutin, and kaempferol.…”

Section: Resultsmentioning

confidence: 99%

Phenolic and Metabolic Profiles, Antioxidant Activities, Glycemic Control, and Anti-Inflammatory Activity of Three Thai Papaya Cultivar Leaves

Chaijan,

Uawisetwathana

et al. 2024

Foods

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This study thoroughly examined the proximate composition, bioactive composition, and in vitro biological activities of three different cultivars of papaya leaf extracts (PLEs) as potential functional ingredients and nutraceuticals. The dark green leaves of three papaya cultivars, Khaek Dam (KD), Holland (H), and Thai Local (L), were used in this study. The protein content of the leaves ranged from 25.96 to 32.18%, the fat content ranged from 7.34 to 11.66%, the carbohydrate content ranged from 5.80 to 17.91%, the moisture content ranged from 6.02 to 6.49%, the ash content ranged from 11.23 to 12.40%, and the fiber content ranged from 23.24 to 38.48%. The L cultivar possessed significantly higher protein and carbohydrate contents, whereas the H cultivar had the highest ash content (p < 0.05). The total phenolic content (TPC) ranged from 113.94 to 173.69 mg GAE/g extract, with the KD cultivar having the highest TPC (p < 0.05). Several metabolic compounds such as phenolic compounds (particularly kaempferol, isorhamnetin, quercetin, ferulic acid, isoferulic acid, salicylic acid, sinapic acid, syringic acid, and vanillin), terpenoids (such as eucalyptol), glycosides, and indole were identified. The PLE from the KD cultivar had the highest levels of DPPH• inhibition, metal chelation, reducing power, and antidiabetic activity (p < 0.05), suggesting superior biological activity. All three PLEs reduced the proliferation of RAW 264.7 cells in a dose-dependent manner with low nitric oxide formation. These results indicate that the papaya leaf, particularly from the KD cultivar, could be a promising source of functional food ingredients.

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Section: Resultsmentioning

confidence: 99%

Phenolic and Metabolic Profiles, Antioxidant Activities, Glycemic Control, and Anti-Inflammatory Activity of Three Thai Papaya Cultivar Leaves

Chaijan,

Uawisetwathana

et al. 2024

Foods

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“…The fatty acids included trans ‐9‐octadecenoic (12.3%), hexadecanoic (2.79%), cis ‐9‐octadecenoic, 2,3‐dihydroxypropyl ester (1.45%), cis ‐9‐octadecenoic methyl ester (1.19%), hexadecanoic trimethylsilyl ester (1.07%), and cis ‐9‐octadecenoic (1.05%). Ghosh, Saha, Bandyopadhyay, and Jana () identified 14 compounds in a papaya seed chloroform extract using GC‐MS. Among the identified compounds, the highest Rt was recorded for oleic acid (28.2%) followed by stearic acid (26.4%).…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory effect of papaya ( Carica papaya ) pulp and seed extracts as a potential natural treatment for bacterial stress

et al. 2019

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The current study evaluated the immunomodulatory effects of Carica papaya pulp and seeds methanol (MeOH) extracts on mice infected with Listeria monocytogenes. Gas chromatography–mass spectrometry analysis identified 10 active constituents in C. papaya seed MeOH extract and 10 compounds in C. papaya pulp MeOH extract. The experimental animals were divided into negative control (G1) group, positive control (G2) group, pulp extract treated (G3) group, and seed extract treated (G4) group. After infection of animals (G2, G3, and G4), treatments were started for 3 weeks. Estimation of the immunological parameters showed a marked decrease in IgM levels and an increase in IgG levels in the treated groups (G3 and G4) compared with those in G2. The proinflammatory cytokines (IL‐10, IL‐12, IL‐1β, IL‐6, and TGF‐β1) were decreased in the treated groups (G3 and G4) compared with those in G2. Nitric oxide levels were also decreased, and the percentages of phagocytosis increased compared with those of G2. The results demonstrated the immunomodulatory and anti‐inflammatory effects of C. papaya pulp and seeds MeOH extracts. Practical applications Based on the antioxidant and antibacterial activities exhibited by the pulp and seed MeOH extracts investigated in this study, Carica papaya might be considered as a natural source of phytochemicals that could be utilized in novel foods and pharmaceuticals. Further investigation are needed to identify and purify compounds that might be responsible for the observed effects.

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“…Isolated compound/ phytochemicals (40) Other phytochemicals  Oleic acid [49]  1,2,3,4-tetrahydropyridin-3-yl-octanoate -An antifertility compound [50].  Fatty acid, amide, nitriles, sterol, fatty aldehydes, and organic acids [51].…”

Section: Plant Partmentioning

confidence: 99%

Therapeutic Potential of Carica papaya Linn.: A Comprehensive Review of Its Pharmacological Properties and Health Benefits, with Emphasis on Dengue Fever Healing

Fernando,

Peiris,

Senadeera

et al. 2024

APRJ

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For thousands of years, people have used various plant products, foods, spices, and herbs to treat and prevent illnesses. Sri Lankans have been using traditional and folk medicine to satisfy their basic health needs from the earliest days. Carica papaya Linn. (Caricaceae) is a commercially grown exotic plant in Sri Lanka. The entire plant, including the fruits both ripened and green, leaves, roots, peel, seed, and pulp, was used as medicine in traditional medicinal systems. Plant parts of Carica papaya Linn. were frequently used by ancient Sri Lankans to treat diabetes mellitus, hypertension, cancer, dengue fever, skin infections, renal disorders, and infections caused by bacteria, fungi, parasites, and viruses. Dengue fever is the most prevalent and significant arthropod-borne viral disease in humans, and it is extensively spread throughout Sri Lanka. Carica papaya Linn. extracts have been used to treat dengue patients to recover from its complications, which include thrombocytopenia, hemolysis, and leukopenia. Studies reveal that the papaya leaf extract can neutralize plasma with the dengue virus, reduce platelet aggregation, and increase the production of the enzyme ALOX12, which promotes platelet production. Moreover, the extract also upregulates the platelet-activating factor receptor (PTAFR) gene and inhibits serine proteases NS2B and NS3 involved in dengue virus replication. In this review, we have discussed extensively the ethnomedicinal and pharmacological properties of Carica papaya while highlighting its remarkable potency in healing dengue.

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Extraction, isolation and characterization of bioactive compounds from chloroform extract of Carica papaya seed and it's in vivo antibacterial potentiality in Channa punctatus against Klebsiella PKBSG14

Cited by 18 publications

References 20 publications

Phenolic and Metabolic Profiles, Antioxidant Activities, Glycemic Control, and Anti-Inflammatory Activity of Three Thai Papaya Cultivar Leaves

Phenolic and Metabolic Profiles, Antioxidant Activities, Glycemic Control, and Anti-Inflammatory Activity of Three Thai Papaya Cultivar Leaves

Immunomodulatory effect of papaya ( Carica papaya ) pulp and seed extracts as a potential natural treatment for bacterial stress

Therapeutic Potential of Carica papaya Linn.: A Comprehensive Review of Its Pharmacological Properties and Health Benefits, with Emphasis on Dengue Fever Healing

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