The Anesthetic Management for a Patient With Trisomy 13

Tsukamoto, Masanori; Hitosugi, Takashi; Esaki, Kanako; Yokoyama, Takeshi

doi:10.2344/anpr-64-02-09

Cited by 4 publications

(6 citation statements)

References 9 publications

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“…It is possible that the hearing aid contributed to the better intelligence development of patient 7 compared to patient 8. Summarizing the reports describing the development of patients with trisomy 13 over 5 years old (Table 5), 7,[11][12][13][14][15] only one patient was able to sit with support, despite the presence of holoprosencephaly. In addition, patients who smiled and made visual contact were those with no or mild brain anomalies.…”

Section: Discussionmentioning

confidence: 99%

“…Thus far, only a few reports have described the activities of daily living (ADL), intellectual ability and/or management of home care of long-term survivors with trisomy 13. 7,[10][11][12][13][14][15] Furthermore, there are no reports on psychomotor developmental progress of such patients. To plan effective treatment and management of patients with trisomy 13, it is necessary to clarify not only the prognosis for life, but also the patients' living situations after discharge and their developmental status.…”

Section: Hirokazu Yamagishimentioning

confidence: 99%

“…Thus far, only a few reports have described the activities of daily living (ADL), intellectual ability and/or management of home care of long‐term survivors with trisomy 13 7,10–15 . Furthermore, there are no reports on psychomotor developmental progress of such patients.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic factors, psychomotor development and life of trisomy 13 patients

Yamagishi

Osaka

Monden

et al. 2022

Pediatrics International

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Background: Infants with trisomy 13 have a very high mortality rate. However, aggressive interventions for their complications, can improve their prognosis and may, thereby, increase the number of long-term survivors with trisomy 13.To date, there is no study on the psychomotor developmental progress of patients with trisomy 13. We conducted this survey to clarify the prognostic factors, living circumstances, and developmental status of infants the trisomy 13.Methods: Patients with trisomy 13 who were admitted to the Department of Pediatrics, Jichi Medical University Hospital were enrolled. Their clinical data were investigated retrospectively using clinical records.Results: Nine patients with trisomy 13 were enrolled and divided into the early death (died at <1 year) and long-term survival (survived for >1 year) groups. All the early death group patients had severe congenital heart disease. Heart failure at under 1 year of age was associated with early death. All the long-term survival group patients underwent operations (e.g. tracheostomy or gastrostomy) and all used home nursing and/or a social care service. Three patients used home mechanical ventilation. None of the patients was able to stand alone or speak intelligible words. Two patients without severe brain anomalies were able to roll over, sit up, and smile by 3 years of age.Conclusions: Long-term survivors with trisomy 13 require extensive nursing and medical care. It is important to provide medical and welfare services to reduce the burden on families. In patients without severe brain anomalies, psychomotor development may be expected. However, no clear developmental prognostic factors were found.

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Section: Discussionmentioning

confidence: 99%

Section: Hirokazu Yamagishimentioning

confidence: 99%

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Prognostic factors, psychomotor development and life of trisomy 13 patients

Yamagishi

Osaka

Monden

et al. 2022

Pediatrics International

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“…We did not provide her premedication before the induction of general anesthesia. General anesthesia was induced with sevoflurane up to 5% and 33% nitrous oxide in oxygen [11]. OSA made mask ventilation difficult even though two anesthesiologists were involved in positioning the head, moving the mandible forward, and opening the mouth to facilitate ventilation.…”

Section: Case Presentationmentioning

confidence: 99%

Opioid-free anesthesia for a child with trisomy 13 with obstructive sleep apnea: a case report

et al. 2020

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Background Most children with trisomy 13 display central apnea, and are prone to opioid-induced respiratory depression. We conducted opioid-free anesthesia for a patient with trisomy 13 and obstructive sleep apnea, and safely extubated the patient in the operating room. Case presentation A 27-month-old girl with trisomy 13 underwent tonsillectomy. Given her high sensitivity to opioids, general anesthesia was introduced and maintained only with 2–5% sevoflurane and 33% nitrous oxide in oxygen. We used acetaminophen for postoperative analgesia. The tracheal tube was removed under stable breathing pattern 10 min after the surgery in the operating room. Two years later, opioid-free anesthesia with 2–5% sevoflurane and 33% nitrous oxide in oxygen was again performed safely for tube insertion into both eardrums. Conclusion Opioid-free anesthesia with adequate non-narcotic analgesics is safe for children with trisomy 13 with multiple apnea-related comorbidities.

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“…Highdose corticosteroid therapy has been reported to be helpful. In anesthetic management, it is essential to perform routine monitoring of the peripheral capillary oxygen saturation (SpO 2 ) and cardiac function (CO [cardiac output], CI [cardiac index], SV [stroke volume], and SVV [stroke volume variation]), using Aesculon ® a noninvasive cardiac function monitor that uses the electrical velocimetry method to measure aortic blood flow, or the NICOM ® which measures the bioreactance, or the phase shift in voltage, across the thorax [35,36]. Hence, we should be aware of the possible development of acute respiratory failure after procedures especially in emergency cases.…”

Section: Anesthetic Planmentioning

confidence: 99%

General Anesthesia for Pediatric Patients with Leukemia

Tsukamoto

Taura

Yamanaka

et al. 2019

SN Compr. Clin. Med.

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Pediatric leukemia is a common cause of disease-related fatality in children aged 1 to 10 years. This disease is usually treated with a combination of chemotherapy, radiation therapy, and bone marrow transplantation. With advancements in cancer treatment, approximately 70-80% of pediatric cancer patients have been cured with these aggressive combination therapies. However, oral and dental infection, mucositis, and necrosis of tissues can occur during the cancer treatment, which may lead to morbidity and an inferior quality of life for pediatric patients with leukemia. Early detection and radical treatment reduce the risk of oral infection and its associated systemic complications. Moreover, dental treatment such as extraction or preventive treatment of teeth should be considered before the start of the cancer treatment. However, it is difficult to provide dental treatment to pediatric patients with leukemia in usual settings due to their uncooperative behavior and/or the presence of psychiatric disorders. Therefore, general anesthesia during dental treatment is often recommended for these patients. In this paper, we reviewed the anesthetic management and perioperative complications in pediatric patients with leukemia receiving general anesthesia.

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The Anesthetic Management for a Patient With Trisomy 13

Cited by 4 publications

References 9 publications

Prognostic factors, psychomotor development and life of trisomy 13 patients

Prognostic factors, psychomotor development and life of trisomy 13 patients

Opioid-free anesthesia for a child with trisomy 13 with obstructive sleep apnea: a case report

General Anesthesia for Pediatric Patients with Leukemia

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