The role of cd34 and d2-40 in the differentiation of dermatofibroma and dermatofibrosarcoma protuberans

Sadullahoğlu, Canan; Dere, Yelda; Atasever, Türkan Rezanko; Öztop, Mine Tunakan; Karaaslan, Önder

doi:10.5146/tjpath.2017.01402

Cited by 9 publications

(16 citation statements)

References 4 publications

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“…What this rearrangement fails to predict is the metastatic potential of the tumor. There is increasing evidence that positive immunoreactivity with CD34 and D2-40 antibody might be the most accurate predictor for the latter (13). Moreover, increased age, high mitotic index and increased cellularity are predictors of poor clinical outcome (2).…”

Section: Discussionmentioning

confidence: 99%

Dermatofibrosarcoma protuberans of the breast: A case study

et al. 2021

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Dermatofibrosarcoma protuberans (DFSP) is a superficial mesenchymal neoplasm that originates from the dermal fibroblasts and tends to be locally aggressive. Although infrequent, it is one of the most common cutaneous sarcomas. It mainly affects young and middle-aged patients 20 to 50 years old. Any area of skin may be involved, but the most common sites of presentation are the trunk and extremities. DFSP of the breast is extremely rare. It classically presents as a nodular, exophytic, cutaneous mass, though initially it can manifest as a flat plague and can show persistent but slow growth for many years. Due to increased risk of local recurrence, the standard of care for localized disease is surgical excision with adequate margins. Wide local excision is the most common technique used, but as an alternative Mohs micrographic surgery has emerged as a procedure that offers lower local recurrence rates. Metastases are rare but have been previously reported. In such patients, treatment with imatinib or radiotherapy can be considered. The current case presents a 52-year-old lady with DFSP of the breast that was successfully managed by the Breast Unit of Athens Medical Center-Psychiko Clinic.

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Section: Discussionmentioning

confidence: 99%

Dermatofibrosarcoma protuberans of the breast: A case study

et al. 2021

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“…Other conditions that can also be considered in the clinical differential diagnosis of atrophic dermatofibroma include local dermatoses such as anetoderma, atrophoderma, non-specific granuloma, and panniculitis. Rarely, systemic illness such as lupus erythematous, morphea, and sarcoidosis have been suspected [1,2,9,10,[12][13][14][15][16][17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

“…Atrophic dermatofibromas characteristically stain positive for factor XIIIa and negative for cluster of differentiation 34, human melanoma black-45, and S100, differentiating this benign lesion from similarly presenting malignant neoplasms such as amelanotic melanoma, dermatofibrosarcoma protuberans, and desmoplastic melanoma. A novel immunohistochemical stain, podoplanin (D2-40), is emerging as another marker in differentiating between dermatofibroma and dermatofibrosarcoma protuberans; however, testing on the atrophic variants of these lesions has not yet been completed (Table 1 ) [ 1 , 2 , 9 , 10 , 12 - 20 ].…”

Section: Discussionmentioning

confidence: 99%

Atrophic Dermatofibroma: A Unique Dermatofibroma Variant

Gutierrez

Calame

Erickson

et al. 2021

Cureus

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Dermatofibromas are benign skin tumors with several variants, including the rare, uncommonly described atrophic dermatofibroma. To the best of our knowledge, there are currently 105 reported cases of atrophic dermatofibromas in the literature. This variant typically presents as a flat or depressed macule whose color can range from brown to white to red; in contrast to classic dermatofibromas that typically occur on the legs, atrophic dermatofibromas have a tendency to occur on the upper back and arms. An atrophic dermatofibroma can be clinically diagnosed; however, given the broad spectrum of clinical features of this lesion, a biopsy may be required. Characteristic pathologic features include epidermal acanthosis, basilar hyperpigmentation, fibroblast hyperplasia, and decreased or absent elastic fibers within the lesion. The pathogenesis of this lesion is not yet fully understood; however, it has been postulated that the loss of elastic fibers plays a key role in its development and characteristic atrophic appearance. We present the cases of two men with biopsy-confirmed atrophic dermatofibromas: a 47-year-old man with a pigmented macule on the right upper back and a 68-year-old man with an erythematous patch on the left posterolateral shoulder. The clinical and pathologic features of atrophic dermatofibromas are also summarized.

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“…This tumour usually characterized by being formed of spindle cells arranged in a storiform pattern with little nuclear pleomorphism and mitosis. DPFS are usually CD34 positive in 90% of the cases and negative to other markers such as S-100, actin and desmin (6).…”

Section: Discussionmentioning

confidence: 99%

Dermatofibrosarcoma of The Breast – Case Report and Review of Literature

Muhammed

Elnakib

Nady

2018

Eur J Breast Health

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Dermatofibrosarcoma protuberans (DFSP) is very rare low-grade neoplasm that arises from the dermal fibroblasts. DPFS has an incidence less than 1 per 100,000 people annually (1). Few authors succeeded to link this a translocation between chromosome 7 and 22 leading to up-regulation of derived growth factor subunit B (PDGFB) gene (2, 3). Although it is common to see local recurrence following excision, this tumor rarely metastasizes. Clinically, it appears as a subcutaneous nodule that grows slowly without any pain (2). Despite its indolent behavior with three years survival rate nearly 90%, DPFS usually resistant to chemotherapy and radiotherapy, thus, complete surgical resection is the gold standard aim of the treatment. The commonest site for DFSP are head, neck and extremities, however, few authors reported the affection of other sites such as the breast, other body parts. This publication discusses the management of a case of DFSP in the breast (2). Case Presentation45 years old female presented to our department with a red-coloured subcutaneous right breast mass, 3 centimetres in maximal dimension and is located at the right lower quadrant of patient's breast. Her workup excluded any systemic metastasis (Figure 1; Sono-mammographic imaging of the tumor). At this stage, the provisional diagnosis was breast cancer with skin involvement. Biopsy from the nodule raised the suspicion of DFSP rather than breast cancer.So, the patient was informed about the nature of her disease, the risk of its recurrence and the possible complications of the treatment in addition to that a written consent was taken from her before further steps in the treatment process. She was subjected to wide resection with sentinel lymph node sampling which excluded any nodal involvement. Final pathological examination showed a tumour composed of malignant spindle cells (figure 2 and 3; spindle shaped cells are arranged in storiform pattern) that are CD 34 positive (Figure 4; diffuse expression of CD34) and CK, S100, ER, PR and CD 68 negative which suggest the diagnosis of low-grade dermatofibrosarcoma protuberans. The surgical resection margin was free of malignant cell involvement but less than 1.5 cm in width.Due to high risk of local recurrence, she was planned to receive adjuvant external beam radiotherapy at a dose of 60 Gy using threedimensional conformal radiotherapy, 3DCRT. She has CT simulation on breast board, supine position, in 5 mm thickness extending from the base of the skull to the level of the iliac crest. The organs at risk; both lungs, heart, right and left ventricles, liver, both kidneys and spinal cord were contoured.

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The role of cd34 and d2-40 in the differentiation of dermatofibroma and dermatofibrosarcoma protuberans

Cited by 9 publications

References 4 publications

Dermatofibrosarcoma protuberans of the breast: A case study

Dermatofibrosarcoma protuberans of the breast: A case study

Atrophic Dermatofibroma: A Unique Dermatofibroma Variant

Dermatofibrosarcoma of The Breast – Case Report and Review of Literature

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