Dermatofibrosarcoma protuberans of the breast: A case study

Dimas, Dionysios; Boutas, Ioannis; Potiris, Anastasios; Koufopoulos, Nektarios; Balalis, Dimitrios; Sitara, Kyparissia; Danglis, Fotios; Misitzis, Ioannis

doi:10.3892/mco.2021.2212

Cited by 7 publications

(13 citation statements)

References 18 publications

(25 reference statements)

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“…Diagnosis of DFSP of the breast is challenging because it is rare and imitates a wide range of benign and malignant breast lesions 8. This is more challenging in paediatric patients regardless of the site of the lesion due to its heterogeneous histological characteristics in this specific cohort,9 as demonstrated in table 2.…”

Section: Discussionmentioning

confidence: 98%

Dermatofibrosarcoma protuberans of the breast

Qadir,

Fatima,

Shaikh

et al. 2024

BMJ Case Rep

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Dermatofibrosarcoma protuberans (DFSP) of the breast is an infrequent soft tissue sarcoma that usually affects young to middle-aged women. Our case report describes a unique occurrence of DFSP of the breast in an adolescent girl, which was initially being managed as a keloid for 2 years under dermatology despite being refractory to treatment. Once the diagnosis of DFSP was confirmed through punch biopsy, our patient underwent surgical excision of the lesion under general anaesthesia. Our patient was at an increased risk of damage to the ductal system due to proximity of the lesion to the nipple–areolar complex, warranting the need for early recognition and treatment. As demonstrated by our case, DFSP of the breast can be difficult to diagnose since it resembles a range of benign and malignant pathologies of the breast.

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Section: Discussionmentioning

confidence: 98%

Dermatofibrosarcoma protuberans of the breast

Qadir,

Fatima,

Shaikh

et al. 2024

BMJ Case Rep

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“…DFSP is a superficial, low-grade soft tissue neoplasm that originates from the dermal fibroblasts and tends to be locally aggressive. The tumor is very uncommon in the breast [ 59 ]. The neoplasm presents diffuse infiltration of the dermis and subcutaneous fat and infrequently involves the glandular tissue.…”

Section: Discussionmentioning

confidence: 99%

Primary de novo malignant peripheral nerve sheath tumor of the breast mimicking mastitis. Report of a case and review of the literature

Val‐Bernal¹,

Hermana²,

Hernánz³

et al. 2023

Rom J Morphol Embryol

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Malignant peripheral nerve sheath tumor (MPNST) is a rare tumor representing <0.1% of malignant breast tumors. Here, we report a case of sporadic MPNST of the breast in a 45-year-old woman with a fast-evolving painful mass in the right breast associated with edema, redness, and increased local temperature, simulating mastitis. This presentation has not been reported. A review of the literature since 1992 has revealed 15 MPNST cases, including the present one with sufficient data for analysis. All the cases were women. The ages ranged from 16–60 years (mean 40.5 years). Duration of symptoms varied from four days to 15 years (mean 2.7 years). Tumor size ranged from 2.5–30 cm (mean 10.9 cm). 64.3% of tumors were well-circumscribed. Tumors were graded as grade 1 (7.7%), grade 2 (38.5%), and grade 3 (53.8%). Three (20%) cases showed histopathological peculiarities. Simple mastectomy was performed in four (26.7%) cases, radical mastectomy in six (40%) cases, and simple excision in five (33.3%) cases. There were no metastases in the six cases where axillary dissection was performed. Seven (53.8%) patients received adjuvant therapy, including chemotherapy and/or radiotherapy. Local recurrence was observed in two (16.7%) patients. Distant metastasis was detected in one patient (7.7%) affecting the lung 11 months after radical mastectomy. The follow-up was available for 10 patients (mean 2.2 years, median 1 year). One patient (10%) died of the disease. At the last follow-up, 80% of patients were still alive. The main differential diagnosis includes nonpleomorphic spindle cell tumors.

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“…Fully developed lesions can show the classic “juga” appearance, and some cases are excised as benign lesions 3,10 . The recommended treatment for DFSP is wide local excision with minimum 3‐cm margins, 11 insufficient resection (depth or width) of the residual tumor cells might lead to a high rate of relapse. In our patient, the tumor was highly active, the first operation and ultrasound examination suggested a clear boundary with no obvious infiltration.…”

Section: Discussionmentioning

confidence: 99%

“…Fully developed lesions can show the classic "juga" appearance, and some cases are excised as benign lesions. 3,10 The recommended treatment for DFSP is wide local excision with minimum 3-cm margins, 11…”

Section: Discussion and Con Clus I On Smentioning

confidence: 99%

Dermatofibrosarcoma protuberans misdiagnosed as sebaceous adenoma and incompletely resected in a child: A case report

Zhang

Chen

Wang

2022

Clinical Laboratory Analysis

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BackgroundDermatofibrosarcoma protuberans is extremely rare in children, making a correct diagnosis by clinicians is usually difficult due to its nonspecific manifestations, the recurrence of dermatofibrosarcoma protuberans after resection has always been a perplexing problem for clinicians. Ultrasound plays an irreplaceable role in the assessment of dermatofibrosarcoma protuberans, although there is a limitation in the diagnosis of the tumor.Case ReportA 10‐year‐old boy led by his parents sought for surgical treatment because of the growing mass. Physical examination and preoperative ultrasonography showed that the mass was clear, and the routine resection of mass was performed. Six days postoperatively, histopathological examination indicated that the mass was dermatofibrosarcoma protuberans, and the peripheral and deep resection margins were positive. The patient was informed that a second extended resection was required. The second postoperative pathology showed a negative margin, and the patient was discharged. Postoperative follow‐up was assessed by ultrasound examination, and the patient had no abnormalities.ConclusionsDermatofibrosarcoma protuberans should be included in the differential diagnosis when the wide base subcutaneous lesion has suspicious features with high vascularity on ultrasound. If an ultrasound reveals a mass with abundant blood flow, clinicians should routinely perform the extended resection. Wide surgical excision may reduce the risk of reoperation and recurrence, and long‐term follow‐up is necessary to evaluate postoperative outcomes.

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Dermatofibrosarcoma protuberans of the breast: A case study

Cited by 7 publications

References 18 publications

Dermatofibrosarcoma protuberans of the breast

Dermatofibrosarcoma protuberans of the breast

Primary de novo malignant peripheral nerve sheath tumor of the breast mimicking mastitis. Report of a case and review of the literature

Dermatofibrosarcoma protuberans misdiagnosed as sebaceous adenoma and incompletely resected in a child: A case report

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