Bone morphological factors influencing cartilage degeneration in the knee

Takahashi, Kenji; Hashimoto, Sanshiro; Kiuchi, Shinji; Watanabe, Atsuya; Nakamura, Hiroshi; Ikuta, Futoshi; Okuaki, Tomoyuki; Kataoka, Takao; Majima, Tokifumi; Takai, Shinro

doi:10.1080/14397595.2017.1332539

Cited by 13 publications

(8 citation statements)

References 20 publications

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“…Increasing evidence has demonstrated the link between posterior tibial slope (PTS) and the biomechanical function of the knee joint. 9 , 34 , 36 The tibial slope plays a role in the anteroposterior stability of the knee joint as well as the range of motion, especially in flexion. 10 Several studies have highlighted the importance of the tibial slope in preoperative planning in orthopaedics, mainly in total knee arthroplasty, high tibial osteotomy, tibial plateau fracture repair, and anterior cruciate ligament (ACL) reconstruction (ACLR).…”

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confidence: 99%

Reliability of Plain Radiographs Versus Magnetic Resonance Imaging to Measure Tibial Slope in Sports Medicine Patients: Can They Be Used Interchangeably?

Jahn

Cooper

Juhan

et al. 2021

Orthopaedic Journal of Sports Medicine

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Background: The slope of the tibial plateau has been proposed as a reason for failure of anterior cruciate ligament reconstruction. Purpose: To evaluate the interobserver reliability of measurements of tibial slope on radiographs versus magnetic resonance imaging (MRI) scans and to assess whether the modalities can be used interchangeably for this purpose. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: This retrospective study included 81 patients aged 18 to 30 years who were evaluated in a sports medicine setting for knee pain and who had lateral knee radiographs as well as knee MRI scans on file. Medial and lateral tibial plateau slope measurements were made by 3 blinded reviewers from the radiographs and MRI scans using graphic overlay software. The paired t test was used to compare measurements of the medial tibial plateau slope (MTPS) and lateral tibial plateau slope (LTPS) from radiographs and MRI scans. Intraclass correlation coefficients (ICCs) were calculated to determine intra- and interobserver reliability of measurements within each imaging modality, and Pearson correlation coefficients were calculated to determine the relationship between measurements on radiographs versus MRI scans. Results: Imaging from 81 patients were included. The average MTPS was significantly larger on radiographs compared with MRI scans (8.7° ± 3.6° vs 3.7° ± 3.4°; P < .001), and the average LTPS was also significantly larger on radiographs compared with MRI scans (7.9° ± 3.4° vs 5.7° ± 3.7°; P < .001). ICC values indicated good to excellent intraobserver agreement for all imaging modalities (ICC, 0.81-0.97; P ≤ .009). The ICCs for interobserver reliability of MTPS and LTPS measurements were 0.92 and 0.85 for radiographs, 0.87 and 0.83 for MRI based off the subchondral bone, and 0.86 and 0.71 for MRI based off the cartilage, respectively ( P < .001). Medium correlation was noted between radiographic and MRI measurements; Pearson correlation coefficients for radiographic versus subchondral MRI measurements were 0.30 and 0.37 for MTPS and LTPS, respectively. Conclusion: The average MTPS and LTPS were significantly larger on radiographs compared with MRI scans. Although tibial slope measurements using radiography and those using MRI are reliable between individuals, the measurements from radiographs and MRI scans cannot be used interchangeably, and caution should be used when interpreting and comparing studies using measurements of the tibial slope.

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confidence: 99%

Reliability of Plain Radiographs Versus Magnetic Resonance Imaging to Measure Tibial Slope in Sports Medicine Patients: Can They Be Used Interchangeably?

Jahn

Cooper

Juhan

et al. 2021

Orthopaedic Journal of Sports Medicine

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“…T 1ρ and T 2 relaxation times are related to the proteoglycan content and collagen orientation of the cartilage and can thus provide information on the state of cartilage health. 7 Elevated T 1ρ and T 2 relaxation times have been associated with the development of knee OA 8,9 and may present biomarkers for early cartilage degeneration. 10 In particular, Teng et al 11 has shown elevated T 1ρ and T 2 relaxation times in individuals with PFJ OA when compared to controls.…”

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confidence: 99%

Longitudinal analysis of the contribution of 3D patella and trochlear bone shape on patellofemoral joint osteoarthritic features

Liao

Jergas

Tibrewala

et al. 2020

Journal Orthopaedic Research

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To explore bone shape features that are associated with patellofemoral joint (PFJ) osteoarthritic features. Thirty subjects with PFJ degeneration (six males, 53.2 ± 9.8 years) and 23 controls (12 males, 48.1 ± 10.6 years) were included. Magnetic resonance (MR) assessment was performed to provide bone segmentation, morpholgocial grading, and cartilage relaxation times. In addition, subject self‐reported symptoms were reported. Logistic regressions were used to identify the shape features that were associated with the presence and worsening of PFJ morphological lesions over 3 years, and worsening of self‐reported symptoms. Statistical parametric mapping was used to evaluate the associations between shape features and cartilage relaxation times at 3 years. Results indicated that subjects with PFJ degeneration exhibited a trochlea with longer lateral condyle and shallower trochlear groove (adjusted odds ratio [OR] = 0.30; 95% confidence interval [CI]: 0.10, 0.86; P = .025). Subjects with worsening of PFJ degeneration exhibited a patella with equally distributed facets (adjusted OR = 3.14; 95% CI: 1.05, 9.37; P = .040) and lateral bump (adjusted OR = 0.14; 95% CI: 0.02, 0.83; P = .030). No shape features were associated with worsening of self‐reported symptoms. Elevated T1ρ and T2 times at 3 years were associated with a patella with a lateral hook, equally distributed facets, round and thick as well as a trochlea larger in size (R = 0.38~0.46, P = .015~.025). The study demonstrated the ability of 3D statistical shape modeling to quantify patella and trochlear bone shape features that are associated with the presence and progression of PFJ osteoarthritic features.

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“…Female gender, advanced age, endocrine and metabolic disorders, overweight, muscle weakness, joint trauma, overload, surgery and inflammatory joint diseases are the main risk factors for OA development [5,6].…”

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confidence: 99%

Effect of the Drug From Soybean and Avocado on the Course of Osteoarthrosis of the Knee Joints With Concomitant Metabolic Syndrome in Women in the Menopausal Period

Yakimenko

Богдан

2017

Technology transfer: innovative solutions in medicine

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The most common articular pathology is osteoarthrosis of the knee joints. More than 10 % of the world's population suffers from this disease. The development of osteoarthrosis (OA) is also affected by metabolic syndrome (MS), which is characterized by abdominal obesity, dyslipidemia, arterial hypertension and disturbance of carbohydrate metabolism. The combination of MS and osteoarthrosis creates conditions of overload for the functioning of axial joints, which is one of the main causes of premature disability and invalidization of the population. Treatment of OA of the knee joints in women in the menopausal period with concomitant metabolic syndrome presents great difficulties. To achieve a stable result of treatment, therapy with chondroprotectors and nonsteroidal anti-inflammatory drugs (NSAIDs) is used. Treatment was carried out in 60 women in the menopausal period with MS, suffering from OA of knee joints. In the group of women in the menopausal period with OA of knee joints and MS who took therapy with the inclusion of the soybean and avocado drug alongside with NSAIDs, a significant effect was obtained with regard to arresting the pain syndrome, improving the quality of life, reducing the degree of inflammation as well as increased joint mobility compared with the group of patients, who took only chondroprotectors and NSAIDs

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Bone morphological factors influencing cartilage degeneration in the knee

Abstract: Shallow MTS correlates with cartilage degeneration in symptomatic patients. This parameter could help in understanding the etiology of osteoarthritis in the early stage. Future kinematic studies will be needed to confirm our findings.

Cited by 13 publications

References 20 publications

Reliability of Plain Radiographs Versus Magnetic Resonance Imaging to Measure Tibial Slope in Sports Medicine Patients: Can They Be Used Interchangeably?

Reliability of Plain Radiographs Versus Magnetic Resonance Imaging to Measure Tibial Slope in Sports Medicine Patients: Can They Be Used Interchangeably?

Longitudinal analysis of the contribution of 3D patella and trochlear bone shape on patellofemoral joint osteoarthritic features

Effect of the Drug From Soybean and Avocado on the Course of Osteoarthrosis of the Knee Joints With Concomitant Metabolic Syndrome in Women in the Menopausal Period

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