Longitudinal analysis of the contribution of 3D patella and trochlear bone shape on patellofemoral joint osteoarthritic features

Abstract

To explore bone shape features that are associated with patellofemoral joint (PFJ) osteoarthritic features. Thirty subjects with PFJ degeneration (six males, 53.2 ± 9.8 years) and 23 controls (12 males, 48.1 ± 10.6 years) were included. Magnetic resonance (MR) assessment was performed to provide bone segmentation, morpholgocial grading, and cartilage relaxation times. In addition, subject self‐reported symptoms were reported. Logistic regressions were used to identify the shape features that were associated with the presence and worsening of PFJ morphological lesions over 3 years, and worsening of self‐reported symptoms. Statistical parametric mapping was used to evaluate the associations between shape features and cartilage relaxation times at 3 years. Results indicated that subjects with PFJ degeneration exhibited a trochlea with longer lateral condyle and shallower trochlear groove (adjusted odds ratio [OR] = 0.30; 95% confidence interval [CI]: 0.10, 0.86; P = .025). Subjects with worsening of PFJ degeneration exhibited a patella with equally distributed facets (adjusted OR = 3.14; 95% CI: 1.05, 9.37; P = .040) and lateral bump (adjusted OR = 0.14; 95% CI: 0.02, 0.83; P = .030). No shape features were associated with worsening of self‐reported symptoms. Elevated T1ρ and T2 times at 3 years were associated with a patella with a lateral hook, equally distributed facets, round and thick as well as a trochlea larger in size (R = 0.38~0.46, P = .015~.025). The study demonstrated the ability of 3D statistical shape modeling to quantify patella and trochlear bone shape features that are associated with the presence and progression of PFJ osteoarthritic features.

SUpervised exercise-therapy and Patient Education Rehabilitation (SUPER) versus minimal intervention for young adults at risk of knee osteoarthritis after ACL reconstruction: SUPER-Knee randomised controlled trial protocol

“…Individual OA feature worsening will be defined as increase in the size or depth of lesions as previously established 50. Bone shape at the knee will also be assessed using edge-detection semiautomated segmentation with 3D triangulated meshes of bone rigidly registered on a reference template to extract the most important modes of variation of bone shape 51…”

Patterns of variation among baseline femoral and tibial cartilage thickness and clinical features: Data from the osteoarthritis initiative

“…PFJ involvement in OA is not rare [ 33 ], is less frequently studied compared to tibiofemoral involvement [ 34 ], and in combination the two likely result in poorer function than either alone [ 35 ]. Specific shape changes on MRI at the PFJ have been associated with PFJ OA [ 36 ]. In addition to the lack of patellar cartilage segmentation, the analysis is limited by the cohort under study, which includes only those with or at risk for knee OA and therefore is not widely generalizable to other groups, and the lack of an available cohort for robust external validation.…”

Patellar instability MRI measurements are associated with knee joint degeneration after reconstruction of the medial patellofemoral ligament

“…In the literature, several MR imaging-based measurements have been described to be associated with patellar instability and trochlear dysplasia [31]. Increased prevalent and progressive patellofemoral degeneration was reported for patients with pathological patellar alignment, patellar tilt, and trochlear dysplasia measurements [11,37,[49][50][51][52][53]. It was reported that by normalizing patellar tracking, patellofemoral contact pressure and joint stress may be decreased [54][55][56][57][58][59].…”