Oxycodone for cancer-related pain

Abstract

, we found six more relevant studies. In total, we included 23 studies with 2648 participants. These studies compared the painkilling ability (benefit) and side effects (harms) of different types of oxycodone to each other or to other strong painkillers. Key results Generally, the studies showed that oxycodone is an equally effective strong painkiller whether taken every six or every hours, and equally effective as other strong pain killers, such as morphine. All the strong painkillers examined in the studies were also associated with a number of unwanted effects, such as vomiting, constipation, and drowsiness. Overall, these do not differ between oxycodone and the other strong painkillers. Hallucinations (where people experience imaginary things, e.g. hearing voices) are much less common as a side effect but we found that they were less likely with oxycodone than within morphine. Overall, we found that the current evidence is comprised of studies that contained small numbers of participants of which many (19%) did not complete the studies. However, since there was very little difference between oxycodone and morphine, more research in this area is unlikely. Studies looking at oxycodone compared to other strong pain killers may be useful. Quality of the evidence We rated the quality of the evidence from studies using four levels: very low, low, moderate, or high. Very low quality evidence means that we are very uncertain about the results. High quality evidence means that we are very confident in the results. Overall the quality of the evidence was low or very low, downgraded because of issues with study quality and size.

Oxycodone ameliorates the inflammatory response induced by lipopolysaccharide in primary microglia

“…Oxycodone (6-deoxy-7,8-dehydro-14-hydroxy-3-O-methyl-6oxomorphine), μ and κ opioid receptor agonist, is widely used for the treatment of a large variety of painful disorders. 4 Previous studies have shown that controlled-release oxycodone improved pain management after uterine artery embolization for symptomatic fibroids, and relieved neuropathic pain in diabetic patients. 5 , 6 And in an animal model, oxycodone was reported to suppress the overactivation of glial cells and the subsequent release of pro-inflammatory cytokines.…”

Guidance and Standards for Breast Cancer Care in Europe

“…ESMO guidelines state that no further axillary procedures are required in patients with limited SLNB involvement or presence of isolated tumour cells (< 0,2 mm) in the SLN, who benefit from breast irradiation (IIB) [ 1 ]. This assertion is backed-up by other European guidance [ 6 ] or meta-analysis [ 19 ]. According to NICE 2018, no further axillary dissection is required in the BCS patients with 1 or 2 sentinel lymph node macro-metastases, planned for whole-breast radiation and systemic, including endocrine therapy [ 6 ].…”

Escalated Oxycodone Self-Administration and Punishment: Differential Expression of Opioid Receptors and Immediate Early Genes in the Rat Dorsal Striatum and Prefrontal Cortex

“…OUDs are characterized by compulsive consumption of large amounts of opioids despite adverse life consequences (American Psychiatric Association and Dsm-5 Task Force, 2013). Adverse consequences of OUDs are influenced by widespread use of opioids such as oxycodone for the treatment of various pain syndromes (Gaskell et al, 2016;Schmidt-Hansen et al, 2017) and their over-prescription by medical professionals (Van Zee, 2009). These have led to substantial increases in the number of deaths caused by opioid overdoses (Skolnick, 2017).…”