Research Article MiR-200c inhibits metastasis of breast tumor via the downregulation of Foxf2.

Zhang, T.; Wan, Jiahui; Liu, J.B.; Deng, Miao

doi:10.4238/gmr16038971

Cited by 17 publications

(16 citation statements)

References 35 publications

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“…22 It has been shown that the expression of miRNA is changed in cancer via several mechanisms such as miRNA gene deletion or amplification. 25 Zhang et al 26 reported that miR-200c suppressed the breast cancer cell metastasis via downregulation of forkhead box F2 expression. Individual miRNAs can regulate multiple mRNAs, and several distinct miRNAs can suppress a single mRNA.…”

Section: Discussionmentioning

confidence: 99%

Retracted: Anticancer effects of miR‐200c in colorectal cancer through BMI1

Mazraehshah

Tavangar

Saidijam

et al. 2018

J of Cellular Biochemistry

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Colorectal cancer (CRC) is one of the most leading cancer deaths throughout the world. MiR-200c has been shown to have a critical role in cancer initiation and progression. In this study, we investigated the miR-200c expression in CRC tissues and its effects on CRC cell lines which were mediated by polycomb complex protein (BMI1). Quantitative reverse transcription polymerase chain reaction (QRT-PCR) and immunohistochemistry were used to detect miR-200c and BMI1 expression in tumor tissues from 38 patients with CRC and 38 normal colon tissues. HCT-116 and SW-48 cells were transfected by locked nucleic acid (LNA)-anti-miR-200c. Western blot analysis and real-time PCR were applied to determine the BMI1 protein and microRNA (miRNA) levels. The apoptosis was analyzed via annexin/propidium iodide staining, and cell invasion was evaluated by transwell assay. MiR-200c was markedly downregulated in CRC tissues, whereas the protein expression of BMI1 in CRC tissues was upregulated compared with normal colon tissues. In the colon cancer cell lines, transfection of LNA-anti-miR-200c increased BMI1 gene and protein expression as well as the cell invasion. Downregulation of miR-200c by LNA decreased the apoptotic cells. The results from this study revealed that miR-200c may have antitumor effects through inhibition of BMI1 expression.

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Section: Discussionmentioning

confidence: 99%

Retracted: Anticancer effects of miR‐200c in colorectal cancer through BMI1

Mazraehshah

Tavangar

Saidijam

et al. 2018

J of Cellular Biochemistry

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“…In lung cancer (except for non-small cell lung cancer 20,21 ) and RMS in mice 35 , FOXF2 mainly shows a promotive effect. In HCC 23 and breast cancer 18,19 , the effect of FOXF2 can be to inhibit and to promote. The roles of FOXF2 in tumours are summarized in Fig.…”

Section: General Descriptionmentioning

confidence: 99%

“…Multiple studies have shown that FOXF2 can have roles in breast cancer 18,19 , lung cancer [20][21][22] , hepatocellular carcinoma (HCC) [23][24][25] , colorectal cancer (CRC) [26][27][28][29] , prostate cancer (PC) [30][31][32] , gastric cancer (GC) 33 , ovarian cancer (OC) 34 , rhabdomyosarcoma (RMS) in mice 35 and other tumours (Table 1). However, FOXF2 can both promote and inhibit proliferation, invasion and metastasis in tumours, depending on the type or subtype of the tumour.…”

Section: Introductionmentioning

confidence: 99%

FOXF2 acts as a crucial molecule in tumours and embryonic development

Kang

Zhu

et al. 2020

Cell Death Dis

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As a key member of the forkhead box transcription factors, forkhead box F2 (FOXF2) serves as a transcriptional regulator and regulates downstream gene expression in embryonic development, metabolism and in some common diseases, such as stroke and gastroparesis. Recent studies have shown that aberrant expression of FOXF2 is associated with a variety of tumorigenic processes, such as proliferation, invasion and metastasis. The role of FOXF2 in the development of many different organs has been confirmed by studies and has been speculated about in case reports. We focus on the mechanisms and signal pathways of tumour development initiated by aberrant expression of FOXF2, and we summarize the diseases and signal pathways caused by aberrant expression of FOXF2 in embryogenesis. This article highlights the differences in the role of FOXF2 in different tumours and demonstrates that multiple factors can regulate FOXF2 levels. In addition, FOXF2 is considered a biomarker for the diagnosis or prognosis of various tumours. Therefore, regulating the level of FOXF2 is an ideal treatment for tumours. FOXF2 could also affect the expression of some organ-specific genes to modulate organogenesis and could serve as a biomarker for specific differentiated cells. Finally, we present prospects for the continued research focus of FOXF2. Facts FOXF2 exhibits inhibitory effects in most tumours. In lung cancer (except for non-small cell lung cancer) and rhabdomyosarcoma in mice, FOXF2 mainly shows a promotive effect. FOXF2 can both inhibit and promote HCC and breast cancer. Regulating the expression level of FOXF2 is an ideal treatment for tumours. Mutations in or deletions of FOXF2 occur in some patients with craniofacial deformities. Mice with suppressed FOXF2 expression show defective organogenesis, such as aglossia, eye deformity, cleft palate and intracranial haemorrhage. Open questions Does FOXF2 have a common mechanism in tumours? What signalling pathways and gene expression does FOXF2 affect in the development of different organs? Are there any specific mechanisms or proteins that can be targeted in the treatment of a FOXF2-affected diseases?

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“…miRNAs are a class of small noncoding RNAs with 18-25 nucleotides, which play as promising targets for diagnosis, prognosis and therapeutics of breast cancer [12]. Previous works have demonstrated that miR-200b and miR-200c could serve as important tumor suppressor by inhibiting cell proliferation, migration and invasion in breast cancer [13][14][15][16][17]. More importantly, the complementary sites between cir-cDENND4C and miR-200b or miR-200c predicted by bioinformatics analysis using starBase stimulated us to hypothesize that miR-200b and miR-200c might be required for circDENND4C-mediated progression of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia

Ren

Liu

Feng

et al. 2019

J Exp Clin Cancer Res

139

105

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Background: Hypoxia is a key feature of breast cancer, which affects cancer development, metastasis and metabolism. Previous studies suggested that circular RNAs (circRNAs) could participate in cancer progression and hypoxia regulation. This study aimed to investigate the role of circRNA differentially expressed in normal cells and neoplasia domain containing 4C (circDENND4C) in breast cancer progression under hypoxia. Methods: Forty-three patients with breast cancer were involved in this study. Breast cancer cell lines MDA-MB-453 and SK-BR-3 were cultured under hypoxia (1% O 2) for experiments in vitro. The expression levels of circDENND4C, microRNA-200b (miR-200b) and miR-200c were measured by quantitative real-time polymerase chain reaction. Glycolysis was investigated by glucose consumption, lactate production and hexokinase II (HK2) protein level. Migration and invasion were evaluated via trans-well assay and protein levels of matrix metallopeptidase 9 (MMP9) and MMP2. The interaction between circDENND4C and miR-200b or miR-200c was explored by bioinformatics analysis, luciferase assay and RNA immunoprecipitation. Murine xenograft model was established to investigate the anti-cancer role of circDENND4C in vivo. Results: circDENND4C highly expressed in breast cancer was up-regulated in response to hypoxia. Knockdown of circDENND4C decreased glycolysis, migration and invasion in breast cancer cells under hypoxia. circDENND4C was validated as a sponge of miR-200b and miR-200c. Deficiency of miR-200b or miR-200c reversed the suppressive effect of circDENND4C knockdown on breast cancer progression. Moreover, silence of circDENND4C reduced xenograft tumor growth by increasing miR-200b and miR-200c. Conclusion: circDENND4C silence suppresses glycolysis, migration and invasion in breast cancer cells under hypoxia by increasing miR-200b and miR-200c.

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Research Article MiR-200c inhibits metastasis of breast tumor via the downregulation of Foxf2.

Cited by 17 publications

References 35 publications

Retracted: Anticancer effects of miR‐200c in colorectal cancer through BMI1

Retracted: Anticancer effects of miR‐200c in colorectal cancer through BMI1

FOXF2 acts as a crucial molecule in tumours and embryonic development

Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia

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