Nanocellulosic materials as bioinks for 3D bioprinting

Piras, Carmen C.; Fernández-Prieto, Susana; Borggraeve, Wim M. De

doi:10.1039/c7bm00510e

Cited by 85 publications

(46 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Arguably, most DIW research with native cellulose materials has been performed with inks consisting of nanostructured cellulose commonly known as nanocellulose. Nanocellulose forms thick shear-thinning gels already at low consistencies which facilitates the printing of high water content freestanding constructs 20 , 21 . One of the most notable applications of AM nanocellulose is biofabrication.…”

Section: Introductionmentioning

confidence: 99%

Shape fidelity and structure of 3D printed high consistency nanocellulose

Klar

Pere

Turpeinen

et al. 2019

Sci Rep

View full text Add to dashboard Cite

The aim of the present study was to investigate the additive manufacturing process for high consistency nanocellulose. Unlike thermoformable plastics, wood derived nanocelluloses are typically processed as aqueous dispersions because they are not melt-processable on their own. The ability to use nanocellulose directly in additive manufacturing broadens the possibilities regarding usable raw materials and achievable properties thereof. Modern additive manufacturing systems are capable of depositing nanocellulose with micrometer precision, which enables the printing of accurate three-dimensional wet structures. Typically, these wet structures are produced from dilute aqueous fibrillar dispersions. As a consequence of the high water content, the structures deform and shrink during drying unless the constructs are freeze-dried. While freeze-drying preserves the geometry, it results in high porosity which manifests as poor mechanical and barrier properties. Herein, we study an additive manufacturing process for high consistency enzymatically fibrillated cellulose nanofibers in terms of printability, shape retention, structure, and mechanical properties. Particular emphasis is placed on quantitative shape analysis based on 3D scanning, point cloud analysis, and x-ray microtomography. Despite substantial volumetric as well as anisotropic deformation, we demonstrate repeatability of the printed construct and its properties.

show abstract

Section: Introductionmentioning

confidence: 99%

Shape fidelity and structure of 3D printed high consistency nanocellulose

Klar

Pere

Turpeinen

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Although cellulose is biocompatible, it presents low cell attachment properties and is non-degradable by human cells. 74 It is mainly used as a supporting material for other bioinks. 48,50,74 Agarose, a seaweed-extracted polysaccharide, with D-galactose and 3,6-anhydro-L-galactopyranose repetition units, (~120 kDa, Fig.…”

Section: Natural Compounds As Network Precursorsmentioning

confidence: 99%

Chemical insights into bioinks for 3D printing

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Besides carbon based polymer composite, the nanocellulose based polymer composites have tremendous potential in medical applications 319 . Due to its biodegradable nature, biocompatibility, and low cytotoxicity, the nanocellulose based composites was used as bio-ink to fabricate 3D bioprinted composite hydrogel implant for cartilage tissue engineering applications 283,320 . The nanofibrillated cellulose (NFC), which made through enzymatic hydrolysis, mechanical shearing, and high-pressure homogenization, was combined with alginate to 3D bio-print human chondrocytes with high fidelity and stability with the optimum compressive stiffness achieved at 70:30 wt% ratio of NFC and alginate 283 .…”

Section: Tissue Engineering Scaffolds or Implantsmentioning

confidence: 99%

Polymer nanocomposites having a high filler content: synthesis, structures, properties, and applications

et al. 2019

View full text Add to dashboard Cite

The recent development of nanoscale fillers, such as carbon nanotube, graphene, and nanocellulose, allows the functionality of polymer nanocomposites to be controlled and enhanced. However, conventional synthesis methods of polymer nanocomposites cannot maximise the reinforcement of these nanofillers at high filler content. Approaches to the synthesis of high content filler polymer nanocomposites are suggested to facilitate future applications. The fabrication methods address design of the polymer nanocomposite architecture, which encompass one, two, and three dimensional morphology. Factors that hamper the reinforcement of nanostructures, such as alignment, dispersion of filler as well as interfacial bonding between filler and polymer are outlined. Using suitable approaches, maximum potential reinforcement of nanoscale filler can be anticipated without limitations in orientation, dispersion, and the integrity of the filler particle-matrix interface. High filler content polymer composites containing emerging materials such as 2D transition metal carbides, nitrides, and carbonitrides (MXenes) are expected in the future.Graphical abstract: Approaches to the synthesis of high filler content polymer composites

show abstract

Nanocellulosic materials as bioinks for 3D bioprinting

Cited by 85 publications

References 44 publications

Shape fidelity and structure of 3D printed high consistency nanocellulose

Shape fidelity and structure of 3D printed high consistency nanocellulose

Chemical insights into bioinks for 3D printing

Polymer nanocomposites having a high filler content: synthesis, structures, properties, and applications

Contact Info

Product

Resources

About