MUC1 Story: Great Expectations, Disappointments and the Renaissance

Syrkina, M. S.; Vassetzky, Yegor S.; Rubtsov, Mikhail A.

doi:10.2174/0929867324666170817151954

Cited by 16 publications

(19 citation statements)

References 83 publications

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“…Por otro lado, la mucina humana MUC-1 asociada a membrana fue descubierta hace unos 40 años como un componente de los glóbulos de grasa de la leche y ha modificado su nombre muchas veces. Antígeno epitelial de membrana (EMA), PAS-O, antígeno DF3, antígeno H23, glucoproteína no penetrante (NPGP), PEM, antígeno NCRC11 son algunas de las denominaciones de esta molécula 10,22 .…”

Section: Discussionunclassified

“…Como mencionamos en la Introducción MUC-1 asociada a la membrana se sobre expresa en las neoplasias malignas perdiendo su localización exclusivamente apical. Ocupa toda la superficie de la membrana, el citoplasma de las células tumorales e incluso el núcleo 10,30 . En nuestro estudio comprobamos por medio de la evaluación histopatológica, la correlación de la expresión de Ki67 y la localización y expresión de MUC-1, que se trata de un adenoma pleomórfico no recurrente y sin transformación maligna.…”

Section: Discussionunclassified

“…Por otro lado, Ki67 es un marcador de proliferación celular que tiene utilidad como factor pronóstico de las neoplasias 9 . En cuanto a MUC-1, es una mucina humana asociada a membrana que en las neoplasias malignas se sobre-expresa y pierde su localización exclusivamente apical 10 . En esta comunicación presentamos un caso de adenoma pleomórfico de glándula lagrimal y estudiamos la expresión de Ki67 y la localización y expresión de MUC-1 y su correlación con el pronóstico tumoral.…”

Section: Introductionunclassified

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Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor

Rosso¹,

Samar²,

Rodolfo³

et al. 2020

RevFacOdont

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Introduction: In daily ophthalmological practice, lacrimal gland tumors are rare. They represent 5 to 7.5% of all intraorbital tumors. The most common epithelial tumor of this gland is the pleomorphic adenoma, with a percentage of 25 to 50% of its tumor lesions. Objective: In this communication we presented a case of lacrimal gland pleomorphic adenoma and study the expression of Ki67 and the location and expression of MUC-1 and its correlation with tumor prognosis. We also carried out a retrospective descriptive study of the literature on the subject published between 1951 and 2020, using the MEDLINE database. Material and methods: The surgical piece examined, was processed according to the paraffin embedding technique, was performed with a histopathological diagnosis of pleomorphic lacrimal gland adenoma. Histological sections were stained with Hematoxylin / Eosin. Immunostaining with Ki67 and MUC-1 was performed with the DAKO LSAB + kit. Results: The diagnosis of hypercellular pleomorphic adenoma with areas of the remaining lacrimal gland was made. Ki67 labeling was low (≤15%). MUC-1 expression was intense, situated to the apical cell membrane of approximately 10% epitheliocytes from pseudoductal and cystic structures.Conclusions: Through histopathological evaluation, the correlation of Ki67 expression and the location and expression of MUC1, we verified that it is a non-recurrent pleomorphic adenoma without malignant transformation.

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Section: Discussionunclassified

Section: Introductionunclassified

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Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor

Rosso¹,

Samar²,

Rodolfo³

et al. 2020

RevFacOdont

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“…En cuanto a MUC1, es una mucina humana asociada a membrana que en las neoplasias malignas se sobre-expresa y pierde su localización exclusivamente apical (Syrkina et al, 2019).…”

Section: Introductionunclassified

Expresión de Ki67 y MUC-1 en el Adenocarcinoma No Especificado de otra Manera (NOS) de Glándulas Salivales: su Valor Pronóstico

Samar-Romani

Ávila-Uliarte

García-Esst

et al. 2020

Int. J. Odontostomat.

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RESUMEN: El adenocarcinoma NOS (no especificado de otra manera) es un tumor salival sin patrón especial poco mencionado en la literatura; su diagnóstico es un desafío porque estructuralmente no se identifica con otros carcinomas salivales más definidos. Por otro lado, Ki67 es un marcador de proliferación celular que brinda información pronóstica de las neoplasias. En cuanto a la mucina humana transmembrana MUC-1 se sobre-expresa en las neoplasias malignas perdiendo su localización exclusivamente apical. Presentamos dos casos de adenocarcinoma NOS diagnosticados con H/E y correlacionamos la expresión de Ki67 y la localización y sobreexpresión de MUC-1 con su grado histológico y pronóstico. Cortes histológicos de dos adenocarcinomas NOS de parótida en mujeres de 62 y 63 años respectivamente se colorearon con H/E e inmunomarcaron para Ki67 y MUC-1. En ambos tumores predominaban estructuras ductales, algunas quísticas, cordones celulares ramificados e islotes sólidos. Las formaciones glandulares presentaban células claras y algunas de aspecto oncocítico. Había importante atipia celular, comedonecrosis, invasión perineural, áreas hemorrágicas y compromiso de los márgenes quirúrgicos. La marcación nuclear con Ki67 fue importante; MUC-1 presentó una fuerte coloración en membranas y citoplasmas. Las dos lesiones se diagnosticaron como de alto grado de malignidad. Nuestros resultados demuestran que existe una importante proliferación marcada con Ki67 y una sobre-expresión de MUC-1 asociadas a atipia celular, infiltración perineural, necrosis y compromiso de márgenes quirúrgicos, factores asociados a un peor pronóstico. El reconocimiento de este tumor es trascendente para médicos y odontólogos ya que por la ausencia de rasgos distintivos que sí presentan otros carcinomas más específicos es fundamental el diagnóstico de exclusión.

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“…Because of the aberrant glycosylation, T-and B-cell epitopes in the peptide backbone are now accessible, forming tumour-associated MUC1 antigens [23,26]. Accordingly, a number of clinical and preclinical studies have delved into MUC1-mediated cancer immunotherapy and vaccination (reviewed elsewhere [27][28][29]).…”

Section: Introductionmentioning

confidence: 99%

Expression of Tumour-Associated MUC1 Is a Poor Prognostic Marker in Breast Cancer in Kumasi, Ghana

Manu

Bedu-Addo

Titiloye

et al. 2020

Journal of Oncology

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Background. Immunohistochemical assessment of breast cancer and stratification into the basic molecular subtypes afford a much deeper insight into the biology of breast cancer, while presenting with opportunities to exploit personalized, targeted treatment. Traditionally, the oestrogen, progesterone, and epidermal growth factor receptors are assessed. MUC1, a transmembrane mucin, has been demonstrated a potential prognostic and metastatic marker in breast cancer. However, there have been a limited number of studies addressing the predictive and prognostic features of MUC1 in African breast cancer. This study aims at addressing the expression profiles of MUC1 and other biomarkers in Ghanaian breast cancer and determines its predictive and prognostic characteristics, in relation to other clinicopathological features. Methods. Haematoxylin and eosin (H&E) slides of breast cancer cases were reviewed and 203 suitable cases were selected for tissue microarray (TMA) construction and immunohistochemistry. Anti-ER, PR, HER2, Ki-67, and MUC1 antibodies were used. Results from the immunostaining were analysed using SPSS version 23. Results. About 59% of cases expressed MUC1. Majority of cases in the study showed a lack of expression of all three traditional markers (29% expressed ER, 10.9% PR, and 20.7% HER2). Ki-67 index were 62.1% (low), 16.5% (moderate), and 21.4% (high). MUC1 expressions among the molecular classes were luminal A (60.7%), luminal B (68.8%), HER2 overexpression (87.5%), and triple negative (56.6%). There were significant associations between MUC1 and HER2 overexpression (p=0.01) and triple negative (p<0.01). Conclusion. The high proportion of breast cancer cases expressing MUC1, as well as its association with the two most aggressive molecular classes, indicate a substantial role in the biology of breast cancer in our cohort, and it is an indication of poor prognosis.

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MUC1 Story: Great Expectations, Disappointments and the Renaissance

Cited by 16 publications

References 83 publications

Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor

Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor

Expresión de Ki67 y MUC-1 en el Adenocarcinoma No Especificado de otra Manera (NOS) de Glándulas Salivales: su Valor Pronóstico

Expression of Tumour-Associated MUC1 Is a Poor Prognostic Marker in Breast Cancer in Kumasi, Ghana

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