Characterization of the metabolic transformation of thiamethoxam to clothianidin in Helicoverpa armigera larvae by SPE combined UPLC–MS/MS and its relationship with the toxicity of thiamethoxam to Helicoverpa armigera larvae

Yu, Fan; Shi, Xueyan

doi:10.1016/j.jchromb.2017.07.054

Cited by 20 publications

(12 citation statements)

References 21 publications

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“…Approximately 378 commercial formulations of thiamethoxam are registered in China. Clothianidin, (E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine) is also a neonicotinoid insecticide and a major metabolite of thiamethoxam with similar structure and insecticidal activity [ 5 , 6 ]. In spite of their merits to increase production, the existence of thiamethoxam and clothianidin could cause neurobehavioral alterations in mammals, posing a risk to consumers’ health [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Dissipation Behavior and Acute Dietary Risk Assessment of Thiamethoxam and Its Metabolite Clothianidin on Spinach

et al. 2022

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Thiamethoxam and its metabolite clothianidin residues pose a potential threat to human health. This study aims to investigate the residue behavior and acute dietary risk assessment of thiamethoxam and clothianidin on spinach. Thiamethoxam and clothianidin were extracted using a quick, easy, cheap, effective, rugged, safe (QuEChERS) method and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). At spike levels from 0.01 to 5 mg kg−1, the average recoveries of both analytes were in the range of 94.5–105.5%, with relative standard deviations (RSDs) of 3.8–10.9%. The dissipation behavior of thiamethoxam followed first-order kinetics, with half-lives of ≤1.6 days. Clothianidin appeared readily as a plant metabolite with highest level exhibited during 3 to 5 days after application. Temperature and light may be two main factors for degradation of thiamethoxam. Besides, acute risk assessment of thiamethoxam and clothianidin was evaluated with risk quotients (RQs) <100%, which suggested a low health risk for all consumer groups of Chinese residents.

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Section: Introductionmentioning

confidence: 99%

Dissipation Behavior and Acute Dietary Risk Assessment of Thiamethoxam and Its Metabolite Clothianidin on Spinach

et al. 2022

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“…Liquid chromatography (LC) (Abd-Alrahman, 2014;Jyot and Singh, 2017;Ramasubramanian et al, 2012;Zhou et al, 2006) and LC-MS (Rahman et al, 2015;Valverde et al, 2016) have been widely used to determine residue and dissipation of thiamethoxam (Gupta et al, 2008;Karmakar and Kulshrestha, 2009;Li et al, 2007;Liu et al, 2009;Pareja et al, 2012;Singh and Kulshrestha, 2005). Efforts have also focused on understanding the degradation of thiamethoxam as well as its metabolites (Fan and Shi, 2017;Hilton et al, 2016;Yang et al, 2014). Besides, based on field trials, the dietary risk has been evaluated e.g.…”

Section: Introductionmentioning

confidence: 99%

Dynamics and dietary risk assessment of thiamethoxam in wheat, lettuce and tomato using field experiments and computational simulation

Pang

Fan

Fantke

et al. 2020

Environmental Pollution

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“…The previous report indicated that thiamethoxam labelled either in the 2-position of the thiazole moiety or on the carbon of the guanidine moiety (4-oxadiazine label) was used in the metabolism and environmental fate studies 5 . Thiamethoxam is transformed to clothianidin in soils, insects and plants, so the part of the insecticidal activity of thiamethoxam was also associated with its metabolite clothianidin 6 . However, the results showed that thiamethoxam and clothianidin would cause rats to release more dopamine in vivo striatum and it seems to be dose-dependent 7 .…”

Section: Introductionmentioning

confidence: 99%

The dissipation of thiamethoxam and its main metabolite clothianidin during strawberry growth and jam-making process

Liu

Pan

Yang

et al. 2018

Sci Rep

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Few studies focused on the residue of thiamethoxam and its metabolite clothianidin on strawberry where it is widely used, despite this is essential to assess the potential food risk of thiamethoxam and its main metabolite clothianidin. In this study, the dissipation of thiamethoxam and its metabolite clothianidin during strawberry growth and jam-making process were assessed. The strawberry was sprayed with thiamethoxam based on the field application to investigate the dissipation of thiamethoxam as well as clothianidin formation. The half-life of thiamethoxam in strawberry was 9.0 days and the concentration of clothianidin in strawberry gradually increased from 0.55 to 11 μg/kg within 30 days. In addition, the amount of thiamethoxam decreased by 51.7% and clothianidin decreased by 40.2% during the homogenization process. The processing factor values of whole processing all less than 1 except simmering. This results from this study will not only help to understand the dissipation kinetics of thiamethoxam and clothianidin in the strawberry, but also facilitate to make more accurate risk assessments of them during strawberry jam making process.

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Characterization of the metabolic transformation of thiamethoxam to clothianidin in Helicoverpa armigera larvae by SPE combined UPLC–MS/MS and its relationship with the toxicity of thiamethoxam to Helicoverpa armigera larvae

Cited by 20 publications

References 21 publications

Dissipation Behavior and Acute Dietary Risk Assessment of Thiamethoxam and Its Metabolite Clothianidin on Spinach

Dissipation Behavior and Acute Dietary Risk Assessment of Thiamethoxam and Its Metabolite Clothianidin on Spinach

Dynamics and dietary risk assessment of thiamethoxam in wheat, lettuce and tomato using field experiments and computational simulation

The dissipation of thiamethoxam and its main metabolite clothianidin during strawberry growth and jam-making process

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