“…A core set of genes expressed in response to OsHV-1 infection has been identified in adults (He et al, 2015;Rosani et al, 2015) and larvae (Zhang et al, 2015), and differences in antiviral gene expression in C. gigas primed with poly(I:C) (Green and Montagnani, 2013;Green et al, 2015b), and their progeny (Green et al, 2016) following inoculation with OsHV-1 have been characterized. Stimulation with double-stranded RNA, such as poly(I:C), induces the expression of antiviral effector genes (Green et al, 2014b), for at least seven days (Green et al, 2014a), and this response appears to inhibit OsHV-1 replication (Lafont et al, 2017;Pauletto et al, 2017). Do C. gigas offspring produced from parents stimulated with poly(I:C) also have elevated expression of antiviral effector genes?…”