Transgenerational plasticity and antiviral immunity in the Pacific oyster (Crassostrea gigas) against Ostreid herpesvirus 1 (OsHV-1)

Lafont, M.; Gonçalves, Priscila; Guo, Ximing; Montagnani, Caroline; Raftos, David A.; Green, Timothy

doi:10.1016/j.dci.2018.09.022

Cited by 33 publications

(20 citation statements)

References 69 publications

(84 reference statements)

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“…The adaptive nature of intergenerationnel effects and chromatin states is worth to investigate since environmental manipulation could be performed with, the intention to induce an 'epigenetic memory' to produce a desired phenotype. Training the innate immunity has been suggested on fishand could be used in oyster aquaculture since transgenerational immunity and long lasting antiviral innate immune priming has been reported in C. gigas (Lafont et al, 2017(Lafont et al, , 2019.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Epigenetic inheritance and intergenerational effects in mollusks

Fallet

Luquet

David

et al. 2020

Gene

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List of abbreviations 5mC5-methylcytosine, a cytosine that has been modified by the addition of a methyl group on its 5th carbon ADP Adenosine diphosphate AFLP Amplified fragment length polymorphism BLAST Basic Local Alignment Search Tool BS-Seq Bisulfite sequencing BS-PCR-Seq PCr amplification after bisulfite sequencing followed by sequencing Cd Cadium meDIP-seq Methylated DNA Immunoprecipitation sequencing MiRNAs Micro RNAs MSAP Methylation-sensitive amplified polymorphism MS-PCR Methylation-specific PCR pCO2 partial pressure of C02 PCR Polymerase chain reaction PTMs Post-Translational Modifications pH potential of Hydrogen qPCR quantitative Polymerase chain reaction RT-qPCR quantitative reverse transcription PCR RNA Ribonucleic acid RRBS Reduced representation bisulfite sequencing SAM S-adenosyl methionine SDS-PAGE Sodium Dodecil Sulfate PolyAcrylamide Gel Electrophoresis UV-HPLC Ultraviolet High performance liquid chromatography Abstract Recent insights in evolutionary biology have shed light on epigenetic variation that interacts with genetic variation to convey heritable information. An important characteristic of epigenetic changes is that they can be produced in response to environmental cues and passed on to later generations, potentially facilitating later genetic adaptation. While our understanding of epigenetic mechanisms in vertebrates is rapidly growing, our knowledge about invertebrates remains lower, or is restricted to model organisms. Mollusks in particular, are a large group of invertebrates, with several species important for ecosystem function, human economy and health. In this review, we attempt to summarize the literature on epigenetic and 4 intergenerational studies in mollusk species, with potential importance for adaptive evolution. Our review highlights that two molecular bearers of epigenetic information, DNA methylation and histone modifications, are key features for development in mollusk species, and both are sensitive to environmental conditions to which developing individuals are exposed. Further, although studies are still scarce, various environmental factors (e.g. predator cues, chemicals, parasites) can induce intergenerational effects on the phenotype (life-history traits, morphology, behaviour) of several mollusk taxa. More work is needed to better understand whether environmentally-induced changes in DNA methylation and histone modifications have phenotypic impacts, whether they can be inherited through generations and their role in intergenerational effects on phenotype. Such work may bring insight into the potential role of epigenetic in adaptation and evolution in mollusks.

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Section: Discussion/conclusionmentioning

confidence: 99%

Epigenetic inheritance and intergenerational effects in mollusks

Fallet

Luquet

David

et al. 2020

Gene

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“…Consequently, many TGIP studies monitored several of these known mechanisms by measuring their activity, such as lysozyme, antimicrobial or phenoloxidase (PO) activities, or their gene expression by RT-qPCR (reverse transcription quantitative PCR) (Table 1; Supplementary Table 1). Only few studies used global approaches to unravel the potential role of other genes and proteins, by using next-generation sequencing (NGS) transcriptomic approach by RNA-seq (46, 58, 69), or by proteomic profiling using 1-dimension (28, 37) or 2D polyacrylamide gel electrophoresis (SDS-PAGE) coupled with mass spectrometry (MS) analysis (60). In future studies, such global approaches should be more widely adopted to identify additional candidates that could be specific to TGIP and have not yet been identified in within-generation immune priming.…”

Section: The Many Roads To Tgip: Hypothetical Scenarios Based On Empimentioning

confidence: 99%

Trans-generational Immune Priming in Invertebrates: Current Knowledge and Future Prospects

et al. 2019

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Trans-generational immune priming (TGIP) refers to the transfer of the parental immunological experience to its progeny. This may result in offspring protection from repeated encounters with pathogens that persist across generations. Although extensively studied in vertebrates for over a century, this phenomenon has only been identified 20 years ago in invertebrates. Since then, invertebrate TGIP has been the focus of an increasing interest, with half of studies published during the last few years. TGIP has now been tested in several invertebrate systems using various experimental approaches and measures to study it at both functional and evolutionary levels. However, drawing an overall picture of TGIP from available studies still appears to be a difficult task. Here, we provide a comprehensive review of TGIP in invertebrates with the objective of confronting all the data generated to date to highlight the main features and mechanisms identified in the context of its ecology and evolution. To this purpose, we describe all the articles reporting experimental investigation of TGIP in invertebrates and propose a critical analysis of the experimental procedures performed to study this phenomenon. We then investigate the outcome of TGIP in the offspring and its ecological and evolutionary relevance before reviewing the potential molecular mechanisms identified to date. In the light of this review, we build hypothetical scenarios of the mechanisms through which TGIP might be achieved and propose guidelines for future investigations.

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“…The immune system of bivalves is exclusively innate, lacking an adaptive memory as in vertebrates, although the existence of a form of immune memory in invertebrates is now being discussed, including in bivalves (see for example Lafont et al, 2019Lafont et al, , 2017. The immune cells, hemocytes, are implicated in multiple physiological functions in bivalves, including nutrition, shell mineralization and tissue repair and, the most important, immunity.…”

Section: Bivalve Immunity and Hemocytesmentioning

confidence: 99%

Effects of marine harmful algal blooms on bivalve cellular immunity and infectious diseases: A review

Lassudrie

Hégaret

Wikfors

et al. 2020

Developmental & Comparative Immunology

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Bivalves were long thought to be "symptomless carriers" of marine microalgal toxins to human seafood consumers. In the past three decades, science has come to recognize that harmful algae and their toxins can be harmful to grazers, including bivalves. Indeed, studies have shown conclusively that some microalgal toxins function as active grazing deterrents. When responding to marine Harmful Algal Bloom (HAB) events, bivalves can reject toxic cells to minimize toxin and bioactive extracellular compound (BEC) exposure, or ingest and digest cells, incorporating nutritional components and toxins. Several studies have reported modulation of bivalve hemocyte variables in response to HAB exposure. Hemocytes are specialized cells involved in many functions in bivalves, particularly in immunological defense mechanisms. Hemocytes protect tissues by engulfing or encapsulating living pathogens and repair tissue damage caused by injury, poisoning, and infections through inflammatory processes. The effects of HAB exposure observed on bivalve cellular immune variables have raised the question of possible effects on susceptibility to infectious disease. As science has described a previously unrecognized diversity in microalgal bioactive substances, and also found a growing list of infectious diseases in bivalves, episodic reports of interactions between harmful algae and disease in bivalves have been published. Only recently, studies directed to understand the physiological and metabolic bases of these interactions have been undertaken. This review compiles evidence from studies of harmful algal Highlights  Review of the main studies on effects of marine harmful algae on bivalve immune cells (hemocytes) and on infectious disease  Harmful algae can modulate host-pathogen interactions in bivalves on various way (increase or decrease the infection)  Some experimental studies report the involvement of cellular immunity and global physiological weakness in the modulations  Other mechanisms possibly involved: HAB effects on bivalve filtration; direct

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Transgenerational plasticity and antiviral immunity in the Pacific oyster (Crassostrea gigas) against Ostreid herpesvirus 1 (OsHV-1)

Cited by 33 publications

References 69 publications

Epigenetic inheritance and intergenerational effects in mollusks

Epigenetic inheritance and intergenerational effects in mollusks

Trans-generational Immune Priming in Invertebrates: Current Knowledge and Future Prospects

Effects of marine harmful algal blooms on bivalve cellular immunity and infectious diseases: A review

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