Nuclear localization of metabolic enzymes in immunity and metastasis

He, Yuchen; Gao, Menghui; Cao, Yiqu; Tang, Haosheng; Liu, Shuang; Tao, Yongguang

doi:10.1016/j.bbcan.2017.07.002

Cited by 28 publications

(22 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Linc01433 is thus a cancer‐related lncRNA that may have an oncogene‐like effect on NSCLC. As chromatin modifiers and metabolism are involve in tumorigenicity, and the interplay of lncRNAs on metabolism is regarded as a hallmark of cancer, it will be interesting to determine whether linc01433 could regulate other possible metabolic targets and the potential mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Long non‐coding RNA linc01433 promotes migration and invasion in non‐small cell lung cancer

et al. 2018

Self Cite

View full text Add to dashboard Cite

BackgroundFor many years, lung cancer has been the most common and deadly cancer worldwide. Early diagnosis of non‐small cell lung cancer (NSCLC) in particular is very difficult because the symptoms are often ignored. The five‐year survival rate is very low despite great improvements to therapy. Thus, there is an urgent need to identify prognostic biomarkers and target molecules for the clinical diagnosis and individualized treatment of NSCLC.MethodsWe performed quantitative real‐time PCR to determine the expression levels of the long non‐coding RNA (lncRNA) linc01433 in NSCLC and normal matched lung tissue. Subsequently, we established cell lines with overexpression or knockdown of linc01433 to evaluate the effects on proliferation and metastasis in vitro. Epithelial‐to‐mesenchymal transition was examined using Western blot.ResultsLinc01433 was significantly overexpressed in NSCLC tissues compared to normal lung tissues. In addition, linc01433 levels were associated with smoking history. Linc01433 overexpression in lung cancer cells increased proliferation, migration, and invasion abilities, as well as epithelial‐to‐mesenchymal transition.ConclusionsLinc01433 is a cancer‐related lncRNA that may have an oncogene‐like effect in NSCLC.

show abstract

Section: Discussionmentioning

confidence: 99%

Long non‐coding RNA linc01433 promotes migration and invasion in non‐small cell lung cancer

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Constitutive activity of a tetramer such as PKM1 allows it to serve as pyruvate kinase in cytosol, favoring the glycolytic process and energy generation, while the less active dimeric PKM2 promotes the accumulation of glycolytic intermediates and subsequent biosynthesis in tumor cells. Importantly, the PKM2 dimer can be imported to the nucleus and function as a protein kinase [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Protein kinase function of pyruvate kinase M2 and cancer

Chen

2020

Cancer Cell Int

View full text Add to dashboard Cite

Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation. PKM2 is one of four isoforms of pyruvate kinase and is widely expressed in many types of tumors and associated with tumorigenesis. In addition to pyruvate kinase activity involving the metabolic pathway, increasing evidence demonstrates that PKM2 exerts a non-metabolic function in cancers. PKM2 has been shown to be translocated into nucleus, where it serves as a protein kinase to phosphorylate various protein targets and contribute to multiple physiopathological processes. We discuss the nuclear localization of PKM2, its protein kinase function and association with cancers, and regulation of PKM2 activity.

show abstract

“…Thus, these studies indicated that LINC00263 plays an important role in lung ADC by the PI3K/AKT/mTOR and NF-κBsignaling pathways. 17 Nuclear factor kappa-B (NF-κB) is a family of transcriptionrelated factors that includes five genes: NF-κB1(P50/P105), NF-κB2 (P52/P100), RelA (P65), c-Rel, and RelB. 18 In most types of cells, NF-κB dimers are predominantly cytoplasmic due to their interaction with the inhibitors of NF-κB (IκBs) and therefore remain transcriptionally inactive.…”

Section: Linc00263 Promotes Cell Growth Colony Formation Invasion mentioning

confidence: 99%

Annotation and cluster analysis of long noncoding RNA linked to male sex and estrogen in cancers

et al. 2020

Self Cite

View full text Add to dashboard Cite

The sex difference in cancer occurrence is a consistent finding in cancer epidemiology. Several solid tumors, including lung cancer, colorectal cancer, hepatic carcinoma, and renal carcinoma, are generally more common in males. Although sexual dimorphism is attributed to hormonal or behavioral differences, evidence for the function of lncRNA is lacking in sex-specific cancers. We show here that LINC00263 is one of the most dysregulated lncRNAs in lung adenocarcinomas and is upregulated in lung adenocarcinoma, colorectal cancer, and renal carcinoma, especially in male patients compared to females. LINC00263 functions as an oncogene by promoting translocation of p65 into the nucleus to activate the NF-κB-signaling pathway through interaction with IKKα in the cytoplasm. The expression of LINC00263 is strongly correlated with ESR1, and it is decreased after treatment with estrogen. Ligand-activated ER could inhibit the function of LINC00263 by inhibiting NF-κB from cytoplasmic translocation into the nucleus. The inhibitory effect of estrogen on LINC00263 indicates its differential expression in male and female patients. Our findings indicate that LINC00263 is linked to male sex and estrogen as an oncogene, and these findings might help in the exploration of the mechanisms of differential gene regulation in sex-specific cancers.

show abstract

Nuclear localization of metabolic enzymes in immunity and metastasis

Cited by 28 publications

References 144 publications

Long non‐coding RNA linc01433 promotes migration and invasion in non‐small cell lung cancer

Long non‐coding RNA linc01433 promotes migration and invasion in non‐small cell lung cancer

Protein kinase function of pyruvate kinase M2 and cancer

Annotation and cluster analysis of long noncoding RNA linked to male sex and estrogen in cancers

Contact Info

Product

Resources

About