Multidrug resistant bacteria are sensitive to Euphorbia prostrata and six others Cameroonian medicinal plants extracts

Voukeng, Igor K.; Beng, Véronique Penlap; Kuete, Victor

doi:10.1186/s13104-017-2665-y

Cited by 25 publications

(13 citation statements)

References 37 publications

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“…However, the methanol leaf extract of V. album was reported to contain alkaloids, terpenes, sterols, flavonoids and polyphenols, whereas a similar extract in our study did not contain sterols [22]. Moreover, our results were similar to those reported in the methanol leave extract of C. verum, which contained alkaloids, flavonoids, phenols, sterols and tannins [23].…”

Section: Plos Onesupporting

confidence: 84%

Reproducibility challenges in the search for antibacterial compounds from nature

Masota

Vogg

Ohlsen³

et al. 2021

PLoS ONE

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Background Reproducibility of reported antibacterial activities of plant extracts has long remained questionable. Although plant-related factors should be well considered in serious pharmacognostic research, they are often not addressed in many research papers. Here we highlight the challenges in reproducing antibacterial activities of plant extracts. Methods Plants with reported antibacterial activities of interest were obtained from a literature review. Antibacterial activities against Escherichia coli and Klebsiella pneumoniae were tested using extracts’ solutions in 10% DMSO and acetone. Compositions of working solutions from both solvents were established using LC-MS analysis. Moreover, the availability of details likely to affect reproducibility was evaluated in articles which reported antibacterial activities of studied plants. Results Inhibition of bacterial growth at MIC of 256–1024 μg/mL was observed in only 15.4% of identical plant species. These values were 4–16-fold higher than those reported earlier. Further, 18.2% of related plant species had MICs of 128–256 μg/mL. Besides, 29.2% and 95.8% of the extracts were soluble to sparingly soluble in 10% DMSO and acetone, respectively. Extracts’ solutions in both solvents showed similar qualitative compositions, with differing quantities of corresponding phytochemicals. Details regarding seasons and growth state at collection were missing in 65% and 95% of evaluated articles, respectively. Likewise, solvents used to dissolve the extracts were lacking in 30% of the articles, whereas 40% of them used unidentified bacterial isolates. Conclusion Reproducibility of previously reported activities from plants’ extracts is a multi-factorial aspect. Thus, collective approaches are necessary in addressing the highlighted challenges.

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Section: Plos Onesupporting

confidence: 84%

Reproducibility challenges in the search for antibacterial compounds from nature

Masota

Vogg

Ohlsen³

et al. 2021

PLoS ONE

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“…Other families are very small with few genera and species. Loranthaceae and Santalaceae are both reported for antibiotic activities ( Kurekci et al, 2012 ; van Vuuren et al, 2015 ; Faboro et al, 2016 ; Voukeng et al, 2017 ; Thielmann et al, 2019 ). However, other families in this clade are not as well studied for unique chemistry and bioactivity ( Kubitzki, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

et al. 2021

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Background: Antimicrobial resistance represents a serious threat to human health across the globe. The cost of bringing a new antibiotic from discovery to market is high and return on investment is low. Furthermore, the development of new antibiotics has slowed dramatically since the 1950s’ golden age of discovery. Plants produce a variety of bioactive secondary metabolites that could be used to fuel the future discovery pipeline. While many studies have focused on specific aspects of plants and plant natural products with antibacterial properties, a comprehensive review of the antibacterial potential of plants has never before been attempted.Objectives: This systematic review aims to evaluate reports on plants with significant antibacterial activities.Methods: Following the PRISMA model, we searched three electronic databases: Web of Science, PubMed and SciFinder by using specific keywords: “plant,” “antibacterial,” “inhibitory concentration.”Results: We identified a total of 6,083 articles published between 1946 and 2019 and then reviewed 66% of these (4,024) focusing on articles published between 2012 and 2019. A rigorous selection process was implemented using clear inclusion and exclusion criteria, yielding data on 958 plant species derived from 483 scientific articles. Antibacterial activity is found in 51 of 79 vascular plant orders throughout the phylogenetic tree. Most are reported within eudicots, with the bulk of species being asterids. Antibacterial activity is not prominent in monocotyledons. Phylogenetic distribution strongly supports the concept of chemical evolution across plant clades, especially in more derived eudicot families. The Lamiaceae, Fabaceae and Asteraceae were the most represented plant families, while Cinnamomum verum, Rosmarinus vulgaris and Thymus vulgaris were the most studied species. South Africa was the most represented site of plant collection. Crude extraction in methanol was the most represented type of extraction and leaves were the main plant tissue investigated. Finally, Staphylococcus aureus was the most targeted pathogenic bacteria in these studies. We closely examine 70 prominent medicinal plant species from the 15 families most studied in the literature.Conclusion: This review depicts the current state of knowledge regarding antibacterials from plants and provides powerful recommendations for future research directions.

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“…African medicinal plants have previously shown efficiency against MDR bacteria with some of them being able to modulate the activity of antibiotics. Some of these plants include Xanthosoma mafaffa, Moringa oleifera, Passiflora edulis [ 5 ], Anthocleista schweinfurthii, Nauclea latifolia, Zehneria scabra [ 6 ], Nauclea pobeguinii [ 7 ], Catharanthus roseus, Croton macrostachys, Paullinia pinnata [ 8 ], Albizia adianthifolia, Alchornea laxiflora, Laportea ovalifolia [ 9 ], Mangifera indica [ 10 ], Ricinodendron heudelotii [ 11 ], and Euphorbia prostrata [ 12 ]. In our continuous search for new botanicals to combat MDR bacteria as well as potentiate the activity of antibiotics, we targeted another African plant, Syzygium jambos (L.) Alston.…”

Section: Introductionmentioning

confidence: 99%

Syzygium jambos Displayed Antibacterial and Antibiotic‐Modulating Activities against Resistant Phenotypes

Wamba

Nayim

Mbaveng

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The present study was designed to evaluate the antibacterial activities of methanol extracts of bark and leaves of Syzygium jambos, as well as their synergistic effects with selected antibiotics against drug-resistant Gram-positive and Gram-negative bacteria. The crude extracts were subjected to qualitative phytochemical screening; broth microdilution method was used for antibacterial assays. Phytochemical studies indicate that leaves and bark extracts contained polyphenols, anthraquinones, tannins, and steroids. Extract of the leaves was active against all the 26 strains of Staphylococcus aureus and all the 21 strains of Gram-negative bacteria tested, within the minimum inhibitory concentration (MIC) range of 32–512 μg/mL. The lowest MIC value of 32 μg/mL was obtained with extract of the leaves against Staphylococcus aureus MRSA9 strain. In Gram-negative bacteria, the lowest MIC value of 64 μg/mL was also obtained against Enterobacter aerogenes EA294 and Klebsiella pneumoniae K24 strains. Against S. aureus strains, antibiotic-modulating activity of extracts at MIC/2 towards more than 70% of the tested strains was obtained when leaves and bark extracts were tested in association with chloramphenicol (CHL). This was also the case when leaves extract was combined with CHL, kanamycin (KAN), tetracycline (TET), and erythromycin (ERY) and when bark extract was combined with ciprofloxacin (CIP), TET, and ERY against Gram-negative bacteria. In conclusion, this study demonstrated that Syzygium jambos has antibacterial and antibiotic-modulating activities.

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Multidrug resistant bacteria are sensitive to Euphorbia prostrata and six others Cameroonian medicinal plants extracts

Cited by 25 publications

References 37 publications

Reproducibility challenges in the search for antibacterial compounds from nature

Reproducibility challenges in the search for antibacterial compounds from nature

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

Syzygium jambos Displayed Antibacterial and Antibiotic‐Modulating Activities against Resistant Phenotypes

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