<i>Syzygium jambos</i> Displayed Antibacterial and Antibiotic‐Modulating Activities against Resistant Phenotypes

Wamba, Brice E. N.; Nayim, Paul; Mbaveng, Armelle T.; Voukeng, Igor K.; Dzotam, Joachim K.; Ngalani, Ornella J. T.; Kuete, Victor

doi:10.1155/2018/5124735

Cited by 28 publications

(12 citation statements)

References 29 publications

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“…Leaf and bark extracts of the plant expressed up to 70% of antibiotic-modulating activity against S. aureus strains at MIC/ 2. Similar results were obtained in association with tetracycline, ciprofloxacin, and erythromycin against Gram-negative bacteria ,6,10,14,18,2,6,10,15,19, including strains of Escherichia coli (AG100ATet, AG102), Enterobacter aerogenes (EA27, EA289), Klebsiella pneumoniae (KP55, KP63), Providencia stuartii (PS299645, NEA16) and Pseudomonas aeruginosa (PA01, PA124) (Wamba et al, 2018). Likewise, S. jambos leaf extracts demonstrated potent antiviral effects on the virus involved in vesicular stomatitis and against different types of herpes simplex virus (Abad et al, 1997;Athikomkulchai et al, 2008).…”

Section: Antimicrobial Activitysupporting

confidence: 69%

“…Microbial growth inhibition zones and percentages, as well as minimum inhibitory concentrations (MICs), demonstrated that S. jambos has potential as a significant antibacterial agent. Wamba et al (2018) reported the capacity of S. jambos extracts to increase the potency of chloramphenicol antibiotic towards bacteria strains expressing MDR phenotype (Wamba et al, 2018). Leaf and bark extracts of the plant expressed up to 70% of antibiotic-modulating activity against S. aureus strains at MIC/ 2.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

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Syzygium jambos L. Alston: An Insight Into its Phytochemistry, Traditional Uses, and Pharmacological Properties

et al. 2022

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Medicinal plants have been used since ancient times for human healthcare as drugs, spices, and food additives. The progress in technology and medicine observed, the last decades, has improved the quality of life and healthcare but with worrisome drawbacks. Side effects caused by synthetic drugs for instance originate sometimes irreversible health disorders. Natural substances, in contrast, are biologically and environmentally friendly. Syzygium jambos L. (Alston) also known as rose apple conveys a long history as essential traditional medicine with a broad spectrum of application in various cultures. The plant discloses a diverse group of secondary metabolites and extracts that displayed major susceptibilities towards various health concerns especially stress-related and inflammatory diseases. Despite a rich literature about the plant, the chemistry and biology of S. jambos have not been comprehensively reviewed yet. Accordingly, we present herein a literature survey of rose apple which aims to draw the chemical identity of the plant and establish a consistent discussion on the respective biological application of plant extracts and their corresponding traditional uses. The present work could provide a scientific basis for future studies and necessary information for further investigations of new drug discovery.

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Section: Antimicrobial Activitysupporting

confidence: 69%

Section: Antimicrobial Activitymentioning

confidence: 99%

Syzygium jambos L. Alston: An Insight Into its Phytochemistry, Traditional Uses, and Pharmacological Properties

et al. 2022

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“…To respond to the current challenges of discovering novel antibiotics, it is important to direct research towards new substances. In accordance with this, previous studies have shown that plants are sources of antimicrobial substances and therefore could be as an alternative to fight against infections due to MDR bacteria [4,[9][10][11][12][13][14][15][16].…”

Section: Introductionsupporting

confidence: 64%

An Efflux Pumps Inhibitor Significantly Improved the Antibacterial Activity of Botanicals from Plectranthus glandulosus towards MDR Phenotypes

Nanmeni

Tedonkeu

Fankam

et al. 2021

The Scientific World Journal

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Bacterial multidrug resistance causes many therapeutic failures, making it more difficult to fight against bacterial diseases. This study aimed to investigate the antibacterial activity of extract, fractions, and phytochemicals from Plectranthus glandulosus (Lamiaceae) against multidrug-resistant (MDR) Gram-negative phenotypes expressing efflux pumps. The crude extract after extraction was subjected to column chromatography, and the structures of the isolated compounds were determined using spectrometric and spectroscopic techniques. Antibacterial assays of samples alone and in the presence of an efflux pump inhibitor (phenylalanine-arginine β-naphthylamide, PAβN) were carried out using the broth microdilution method. The phytochemical study of P. glandulosus plant extract afforded seven major fractions (A–G) which lead to the isolation of seventeen known compounds. The ethanol extract of P. glandulosus was not active at up to 1024 μg/mL, whereas its fractions showed MICs varying from 32 to 512 μg/mL on the studied bacteria. Fraction C of P. glandulosus showed the lowest MIC (32 μg/mL) on E. coli ATCC8739 strain. Fraction D presented the highest activity spectrum by inhibiting the growth of 90% (9/10) of the studied bacteria. The presence of PAβN has improved the activity of extract and all fractions. Overall, the tested phytochemicals showed low activity against the studied bacteria. The overall results obtained in this study show that some fractions from P. glandulosus, mainly fractions C and D, should be investigated more for their possible use to fight against MDR bacteria.

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“…The diversity of endophytic fungi from S. jambos and other species of the genus Syzygium is shown in Table 6. The potential of S. jambos bark extract has been known to have antibacterial activity against Staphylococcus aureus, Escherichia coli, Salmonella typhi, Bacillus subtilis (Murugan et al 2011;Begum et al 2015;Wamba et al 2018), and Propionibacterium acnes (Sharma et al 2013b). It has been reported that chemical compounds from the bark extract of S. jambos contain polyphenols, anthraquinones, tannins, triterpenes, steroids, saponins (Wamba et al 2018), pentacyclic triterpene, sitosterol, triterpene derivative 3-nor-2,3-fridelan (Haque et al 2015), jambosine alkaloids, pedunculagin ellagitannins, casuarinin, tellimagrandin I, strictinin, casuarictin, 2,3-HHDP glucose, and tellimagrandin II (Baliga et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of endophytic fungi isolated from the stem bark of jambu mawar (Syzygium jambos)

et al. 2022

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Abstract. ‘Aini K, Elfita, Widyajanti H, Setiawan A, Kurniawati AR. 2021. Antibacterial activity of endophytic fungi isolated from the stem bark of jambu mawar (Syzygium jambos). Biodiversitas 23: 521-532. Syzygium jambos (jambu mawar) is widely used in South Sumatra as a traditional medicine to treat various diseases, including pathogenic bacterial infections. Literature studies report that parts of S. jambos have been used worldwide for treating diarrhea accompanied by fever, dysentery, sore throat, diabetes, and other infectious diseases. Endophytic fungi isolated from medicinal plants have high diversity, and the biological activity of their secondary metabolites is associated with their host. Therefore, this study aimed to determine the diversity of endophytic fungi from the stem bark of S. jambos and the antibacterial activity of secondary metabolites of endophytic fungi. Fungal isolates with high antibacterial activity were identified to obtain fungal species, and the structure of their compounds was determined. The disc diffusion method carried the antibacterial activity test against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Salmonella typhi) bacteria. Characteristics of endophytic fungi were identified microscopically and macroscopically. Active endophytic fungi were identified by molecular analysis of the internal transcribed region (ITS) of the ribosomal DNA. Isolation of antibacterial compounds using chromatographic techniques and determination of chemical structures using spectroscopy was performed. Eight endophytic fungi were obtained from the stem bark of S. jambos, namely SJ1–SJ8. The endophytic fungus SJ6 showed the highest activity and base on phylogenetic analysis, was identified as Fusarium verticillioides. Pure compounds isolated as yellowish-white solids showed good antibacterial activity against S. aureus and S. typhi with minimum inhibitory concentration values of 64 g/mL each. Based on 1D and 2D nuclear magnetic resonance spectroscopic analysis, compound 1 was identified as 3-hydroxy-4-(hydroxy(4-hydroxyphenyl)methyl)dihydrofuran-2-on.

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Syzygium jambos Displayed Antibacterial and Antibiotic‐Modulating Activities against Resistant Phenotypes

Cited by 28 publications

References 29 publications

Syzygium jambos L. Alston: An Insight Into its Phytochemistry, Traditional Uses, and Pharmacological Properties

Syzygium jambos L. Alston: An Insight Into its Phytochemistry, Traditional Uses, and Pharmacological Properties

An Efflux Pumps Inhibitor Significantly Improved the Antibacterial Activity of Botanicals from Plectranthus glandulosus towards MDR Phenotypes

Antibacterial activity of endophytic fungi isolated from the stem bark of jambu mawar (Syzygium jambos)

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