Primary signet ring stromal tumor of the testis: a study of 13 cases indicating their phenotypic and genotypic analogy to pancreatic solid pseudopapillary neoplasm

Michalová, Květoslava; Kazakov, Dmitry V.; Sedivcova, Monika; Hes, Ondřej; Hadravský, Ladislav; Agaimy, Abbas; Tretiakova, Maria; Bacchi, Carlos E.; Hartmann, Arndt; Bulimbašić, Stela; Čorić, Marijana; Antic, Tatjana; Michal, Michal

doi:10.1016/j.humpath.2017.07.010

Cited by 27 publications

(33 citation statements)

References 26 publications

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“…In our case, the tumour showed a mutation in the CTNNB1 gene with c.98C>G (p Ser33Cys), as described above. In the study by Michalova et al., two cases of PSRSTT also showed the same mutation (Table ) . Interestingly, we found out from the previous study that of 53 investigated sex cord‐stromal tumours, one Sertoli cell tumour also had the same CTNNB1 mutation as described in the present case .…”

Section: Discussionsupporting

confidence: 83%

“…In comparison to the study of Michalova et al. , this PSRSTT did not show a positive staining for CD10 and CD56 (Table ).…”

Section: Discussioncontrasting

confidence: 77%

“…The most important difference to distinguish Sertoli cell tumours from PSRSTT is the expression of sex cord‐stromal markers such as calretinin, inhibin or SF‐1, as postulated by Michalova et al. .…”

Section: Discussionmentioning

confidence: 98%

“… in 2005. Since then, it has been described only in 14 other cases . Tumours with similar histological features have been found in the ovary before and have been first described in 1975 .…”

mentioning

confidence: 96%

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Primary signet‐ring stromal tumour of the testis: case report with literature review

Fichtner

Fisseler‐Eckhoff

Kramer

et al. 2018

APMIS

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Primary signet‐ring stromal tumour of the testis (PSRSTT) is a very rare type of primary testicular tumour, which is not actually mentioned in the current WHO categorization of tumours of the male genital organs. In this case we report about histologically and immunohistochemically features of this rare tumour. In the present case, PSRTT was found in the orchiectomy preparation of a 69‐year‐old man with painless swelling of his left testicle. The tumour was well circumscribed and separated from the normal testicular tissue by a fibrous capsule. The tumour cells showed a signet‐ring pattern and were separated by thin collagen bundles. No mitotic activity and necrosis were found inside the tumour. Immunohistochemically, the tumour was positive for vimentin, neuron‐specific enolase (NSE), S‐100 protein, β‐catenin and cyclin D1. No expression of cytokeratin, actin, SALL4, OCT3/4, and especially, inhibin and calretinin were detected. In conclusion, the presence of signet‐ring cell formation can be found in different tumours of the testis. PSRSTT is a rare tumour that needs to be considered, in particular, to distinct them from other tumours with signet‐ring cell pattern.

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Section: Discussionsupporting

confidence: 83%

“…In comparison to the study of Michalova et al. , this PSRSTT did not show a positive staining for CD10 and CD56 (Table ).…”

Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 98%

“… in 2005. Since then, it has been described only in 14 other cases . Tumours with similar histological features have been found in the ovary before and have been first described in 1975 .…”

mentioning

confidence: 96%

See 2 more Smart Citations

Primary signet‐ring stromal tumour of the testis: case report with literature review

Fichtner

Fisseler‐Eckhoff

Kramer

et al. 2018

APMIS

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show abstract

“…Twenty‐one of 33 (64%) sex cord‐stromal tumours, not otherwise specified (NOS), six of 10 (60%) sclerosing stromal tumours and four of six (67%) Sertoli cell tumours showed diffuse beta‐catenin nuclear staining, while other sex cord‐stromal tumours were negative . Primary signet ring‐stromal tumour of the testis has also been shown to exhibit nuclear staining with beta‐catenin and to contain CTNNB1 mutations …”

Section: Discussionmentioning

confidence: 99%

Expanding the morphological spectrum of ovarian microcystic stromal tumour

et al. 2018

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Aims To expand the morphological spectrum of ovarian microcystic stromal tumour, a rare neoplasm considered to have a relatively constant morphology with microcysts, solid cellular regions and hyalinised fibrous stroma. Methods and results We report four ovarian neoplasms in patients aged 45, 56, 61 and 71 years with the characteristic immunophenotype of microcystic stromal tumour (diffuse nuclear positivity with beta‐catenin, cyclin D1 and WT1; diffuse cytoplasmic positivity with CD10; negative inhibin, calretinin, oestrogen receptor and progesterone receptor). The tumours had variant morphology (diffuse, nested and corded arrangements in three cases, including one with spindle cell elements; nested, corded and tubular in the other). A CTNNB1 point mutation in exon 3 (c.98C>G,p.S33C; c.100G>A,p.G34R; c.97T>G,p.S33A) was present in the three cases with material available for testing. Conclusions We feel that the cases we report are related to microcystic stromal tumour but with variant morphology; as such, the morphological spectrum of ovarian microcystic stromal tumour is broader than hitherto reported.

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Testis and Paratesticular Tissues

Wilkerson

Liu

2022

Handbook of Practical Immunohistochemistry

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Primary signet ring stromal tumor of the testis: a study of 13 cases indicating their phenotypic and genotypic analogy to pancreatic solid pseudopapillary neoplasm

Cited by 27 publications

References 26 publications

Primary signet‐ring stromal tumour of the testis: case report with literature review

Primary signet‐ring stromal tumour of the testis: case report with literature review

Expanding the morphological spectrum of ovarian microcystic stromal tumour

Testis and Paratesticular Tissues

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