Primary signet‐ring stromal tumour of the testis: case report with literature review

Abstract

Primary signet‐ring stromal tumour of the testis (PSRSTT) is a very rare type of primary testicular tumour, which is not actually mentioned in the current WHO categorization of tumours of the male genital organs. In this case we report about histologically and immunohistochemically features of this rare tumour. In the present case, PSRTT was found in the orchiectomy preparation of a 69‐year‐old man with painless swelling of his left testicle. The tumour was well circumscribed and separated from the normal testicular tissue by a fibrous capsule. The tumour cells showed a signet‐ring pattern and were separated by thin collagen bundles. No mitotic activity and necrosis were found inside the tumour. Immunohistochemically, the tumour was positive for vimentin, neuron‐specific enolase (NSE), S‐100 protein, β‐catenin and cyclin D1. No expression of cytokeratin, actin, SALL4, OCT3/4, and especially, inhibin and calretinin were detected. In conclusion, the presence of signet‐ring cell formation can be found in different tumours of the testis. PSRSTT is a rare tumour that needs to be considered, in particular, to distinct them from other tumours with signet‐ring cell pattern.

Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features

“…Both predominantly sclerosing tumors and Sertoli cell NOS show CTNNB1 gene mutation and nuclear positivity for ß-catenin 67,72 . CTNNB1 gene mutations were demonstrated in 60% to 70% of the cases 44,71,72,76. A gain of X chromosome was seen in up to 40% of tumors.…”

“…67,72 CTNNB1 gene mutations were demonstrated in 60% to 70% of the cases. 44,71,72,76 A gain of X chromosome was seen in up to 40% of tumors. Less commonly, complete or partial losses of chromosomes 2 and 19 have been documented.…”

Sex cord stromal tumors and tumors of the paratestis: new and old entities in a landscape of rare tumors

“…They both present as asymptomatic intratesticular masses; in both instances levels of serum markers are not increased. Age of presentation is variable: SRST spans from 29 to 69 years of age, [11][12][13] whereas MGST is mainly found in adults (mean age about 40 years), although it has also been reported in a 4year-old boy [14]. Etiology and pathogenesis of…”

“…A complete immunohistochemical characterization of these tumors in the context of testicular sex cord stromal tumors has been recently published [18 && ]. All cases of SRST and MGST reported so far have behaved in a benign fashion after resection [11,16] and whenever possible a conservative surgery is recommended.…”

“…All cases of SRST and MGST reported so far have behaved in a benign fashion after resection [11,16] and whenever possible a conservative surgery is recommended.…”