Vacunación con pertussis en el embarazo: una estrategia segura y efectiva para proteger al lactante menor

Abstract

Vacunación con pertussis en el embarazo: una estrategia segura y efectiva para proteger al lactante menor Keywords:Whooping cough, Bordetella pertussis, diphtheria-tetanuspertussis vaccine AbstractWhooping cough is an immune preventable disease that can be life threatening. Despite infant immunization starting at 2 month of age, there are many cases and outbreaks in our country and also around the world, with a high risk of mortality especially in infants under 6 month of age. It has been proposed that antenatal vaccination with acellular pertussis component (Tdap) would be useful, safe and effective since it transfers a high antibody rate to the child, reducing the incidence of pertussis in this group by 85%. No higher incidence of adverse effects has been found in pregnant women with this vaccine. This strategy has been implemented in several developed and Latin American countries. The purpose of this manuscript is to review and discuss the benefits of antenatal vaccination with Tdap. It was concluded that maternal immunization with Tdap vaccine should be promoted to prevent infection and associated mortality in infants under 6 months of age by Bordetella pertussis.

Cambios epidemiológicos y actualidades sobre vacunación contra Bordetella pertussis en Latinoamérica

“…Otra medida importante es la vacunación materna, que protege a los niños pequeños que no han comenzado el esquema vacunal y reduce la incidencia y la letalidad de tosferina. La vacunación materna como estrategia segura en la reducción de la incidencia de tosferina escapa al ámbito de esta revisión; sin embargo, existen revisiones recientes del tema y los primeros datos de impacto en Latinoamérica 4,33,34,40,41 .…”

Neonatal Immunity toBordetella pertussisInfection and Current Prevention Strategies

“…Recently, cocooning was recommended in Latin America in Brazil, Chile, and Costa Rica [45]. In Chile, in 2012-2013, it is estimated that 84% of potential pertussis deaths in infants were prevented [82], but in other countries around the world, current data found a minor or no impact of this approach [83]. Therefore, the efficacy of cocooning is limited because the child has no specific protection, and the approach demands the vaccination of several adults, making cocooning both costly and difficult to implement [79].…”