Perinatal protein deprivation facilitates morphine cross-sensitization to cocaine and enhances ΔFosB expression in adult rats

Perondi, María Cecilia; Gutiérrez, María Cecilia; Valdomero, Analía; Cuadra, Gabriel

doi:10.1016/j.bbr.2017.06.051

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…They also found that genetic knockdown of CREB in the NAc of group‐housed mice induced EE animals' behavioral phenotype among group‐housed ones (Green et al, 2010). Both physiological and psychological insults could modulate ΔFosB expression (Hinwood et al, 2011; Perondi et al, 2017). For example, chronic social defeat stress increased ΔFosB expression in the prelimbic cortex, which caused neuronal hypoactivity and anxiogenic behaviors (Vialou et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Sex‐specific effects of developmental morphine exposure and rearing environments on hippocampal spatial memory

Sarkaki

Mard

Bakhtiari

et al. 2022

Intl J of Devlp Neuroscience

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Developmental morphine (MOR) exposure (DME) detrimentally affects the cognitive abilities of the next generation. It is shown that postnatal rearing environments and prenatal conditions effectively impact memory. The present study investigated the effects of DME, postweaning rearing, and sex on spatial learning and memory. At molecular level, we evaluated mRNA levels of brainderived neurotrophic factor, cyclic AMP response element-binding protein (CREB), μ-opioid receptor, and ΔFosB in the hippocampus of male offspring. Female Wistar rats were treated with escalating doses of MOR or saline before mating, gestation, and lactation. On Postnatal Day 22, the male and female pups were divided into 12 groups and raised for 2 months under different conditions: standard, isolated (ISO), or enriched environment. Afterward, the Morris water maze task measured spatial learning and reference memory; rats were then sacrificed to assess hippocampus gene expressions. Results indicated the DME and isolated rearing increased latency to find the hidden platform in male offspring. DME was insignificant in female offspring, whereas rearing environments significantly altered escape latency in both sexes. We also found that the enriched environment upregulated the brain-derived neurotrophic factor mRNA in both saline and MOR groups, whereas it downregulated the mRNA levels of CREB1, μ-opioid receptor, and ΔFosB in the MOR group. In addition, the DME enhanced CREB1, μ-opioid receptor, and ΔFosB gene expression in the MOR + isolated group. Our findings signified the effects of DME, rearing environment, and sex on the spatial learning abilities of offspring. Also, we showed that DME and rearing conditions could manipulate hippocampal neurochemistry. K E Y W O R D S CREB, enriched environment, morphine, sex, ΔFosB, μ-opioid receptor 1 | INTRODUCTION Developmental toxic exposure has long-lasting impacts on the immature nervous system. Opioids are among the most abused drugs during pregnancy, adversely

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Section: Discussionmentioning

confidence: 99%

Sex‐specific effects of developmental morphine exposure and rearing environments on hippocampal spatial memory

Sarkaki

Mard

Bakhtiari

et al. 2022

Intl J of Devlp Neuroscience

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“…The neurochemical alterations underlying this condition have been examined in different animal models of perinatal malnutrition that have focused on the ventral striatum / nucleus accumbens (NAC) as a key brain area in addiction. Thus, Delta Fos B, a transcription factor closely related to drug addiction, was found upregulated in the NAC of rats undergoing protein deprivation [6]. Perinatal malnutrition affects dopaminergic and serotoninergic function in the NAC, as shown by the enhanced reactivity to 5-HT6 receptor agonists [7] and the increased expression of the dopamine receptor D1a gene [8].…”

Section: Introductionmentioning

confidence: 94%

Perinatal undernourishment provokes long-lasting alterations of clusterin and fumarate hydratase expression in the rat nucleus accumbens

Rodríguez-Rivera

González‐Martín

Fernández-Millán

et al. 2021

Nutritional Neuroscience

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Perinatal malnutrition seems to provoke important neurochemical alterations in the brain that lead to higher vulnerability to develop neuropsychiatric disorders in the adulthood. In this work we have examined the persistence and reversibility of the changes induced by perinatal undernourishment on the expression of fumarate hydratase in the rat nucleus accumbens, bearing in mind that this expression has been previously linked with addictive disorders. Clusterin, a multifunctional protein known to be neuroprotective and possibly related to addiction in humans, was studied in parallel.Female rats under severe restriction of food during gestation, lactation and 5 months of postnatal life showed a marked upregulation of both clusterin and fumarate hydratase in the mitochondrial fraction of the nucleus accumbens, as quantified by western blot. In the case of clusterin, this upreglation was also observed in the cytosolic fraction of the nucleus accumbens. When animals were undernourished only during gestation and lactation but then switched to normal chow upon weaning, the two proteins appeared downregulated with respect to controls. The results are consistent with the idea that perinatal malnutrition provokes marked changes of brain neurochemistry that are not fully corrected by the rehabilitation of normal feeding and could be linked to behavioural disturbances in the adulthood, i.e. increased vulnerability to addiction.

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Effect of histone acetylation on maintenance and reinstatement of morphine-induced conditioned place preference and ΔFosB expression in the nucleus accumbens and prefrontal cortex of male rats

Saberian

Taei

Torkaman-Boutorabi

et al. 2021

Behavioural Brain Research

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Perinatal protein deprivation facilitates morphine cross-sensitization to cocaine and enhances ΔFosB expression in adult rats

Cited by 5 publications

References 46 publications

Sex‐specific effects of developmental morphine exposure and rearing environments on hippocampal spatial memory

Sex‐specific effects of developmental morphine exposure and rearing environments on hippocampal spatial memory

Perinatal undernourishment provokes long-lasting alterations of clusterin and fumarate hydratase expression in the rat nucleus accumbens

Effect of histone acetylation on maintenance and reinstatement of morphine-induced conditioned place preference and ΔFosB expression in the nucleus accumbens and prefrontal cortex of male rats

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