Effect of histone acetylation on maintenance and reinstatement of morphine-induced conditioned place preference and ΔFosB expression in the nucleus accumbens and prefrontal cortex of male rats

Saberian, Hashem; Taei, Afsaneh Asgari; Torkaman-Boutorabi, Anahita; Riahi, Esmail; Aminyavari, Samaneh; Naghizadeh, Ayeh; Farahmandfar, Maryam

doi:10.1016/j.bbr.2021.113477

Cited by 7 publications

(3 citation statements)

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“…These two inhibitors more consistently reduce drug-related behaviors. SAHA reduces contingent ethanol intake, ethanol self-administration, ethanol-seeking ( Warnault et al, 2013 ), and SAHA also increases extinction and reduces non-contingent CPP reinstatement to morphine ( Saberian et al, 2021 ). Like SAHA, VPA also reduces ethanol drinking and ethanol CPP ( Al Ameri et al, 2014 ).…”

Section: Effects Of Systemically Injected Inhibitors Of Epigenetic Re...mentioning

confidence: 99%

“…Activators of HDACs have also been studied, but rarely. The HDAC activator theophylline decreases extinction to non-contingent morphine CPP and ( Saberian et al, 2021 ) the SIRT agonist resveratrol increases non-contingent cocaine CPP ( Renthal et al, 2009 ). Since these studies suggest that HDAC activation increases drug-related behaviors, they complement some of the HDAC inhibitor studies that show decreases in drug-related behaviors.…”

Section: Effects Of Systemically Injected Inhibitors Of Epigenetic Re...mentioning

confidence: 99%

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Epigenetic Effects of Addictive Drugs in the Nucleus Accumbens

Anderson

Taniguchi

2022

Front. Mol. Neurosci.

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Substance use induces long-lasting behavioral changes and drug craving. Increasing evidence suggests that epigenetic gene regulation contributes to the development and expression of these long-lasting behavioral alterations. Here we systematically review extensive evidence from rodent models of drug-induced changes in epigenetic regulation and epigenetic regulator proteins. We focus on histone acetylation and histone methylation in a brain region important for drug-related behaviors: the nucleus accumbens. We also discuss how experimentally altering these epigenetic regulators via systemically administered compounds or nucleus accumbens-specific manipulations demonstrate the importance of these proteins in the behavioral effects of drugs and suggest potential therapeutic value to treat people with substance use disorder. Finally, we discuss limitations and future directions for the field of epigenetic studies in the behavioral effects of addictive drugs and suggest how to use these insights to develop efficacious treatments.

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Section: Effects Of Systemically Injected Inhibitors Of Epigenetic Re...mentioning

confidence: 99%

Section: Effects Of Systemically Injected Inhibitors Of Epigenetic Re...mentioning

confidence: 99%

Epigenetic Effects of Addictive Drugs in the Nucleus Accumbens

Anderson

Taniguchi

2022

Front. Mol. Neurosci.

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“…Previous studies have shown that epigenetic changes, such as increased histone acetylation and DNA methylation, play a critical role in mediating morphine effects [13] , [14] . However, it is still unknown how the 3D configuration of the genome is linked to morphine effects.…”

Section: Introductionmentioning

confidence: 99%

Morphine Re-Arranges Chromatin Spatial Architecture of Primate Cortical Neurons

Wang

Liu

et al. 2023

Genomics, Proteomics &Amp; Bioinformatics

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The expression of linear DNA sequence is precisely regulated by the three-dimensional (3D) architecture of chromatin. Morphine-induced aberrant gene networks of neurons have been extensively investigated; however, how morphine impacts the 3D genomic architecture of neurons is still unknown. Here, we applied digestion-ligation-only high-throughput chromosome conformation capture (DLO Hi-C) technology to investigate the effects of morphine on the 3D chromatin architecture of primate cortical neurons. After receiving continuous morphine administration for 90 days on rhesus monkeys, we discovered that morphine re-arranged chromosome territories, with a total of 391 segmented compartments being switched. Morphine altered over half of the detected topologically associated domains (TADs), most of which exhibited a variety of shifts, followed by separating and fusing types. Analysis of the looping events at kilobase-scale resolution revealed that morphine increased not only the number but also the length of differential loops. Moreover, all identified differentially expressed genes from the RNA sequencing data were mapped to the specific TAD boundaries or differential loops, and were further validated for changed expression. Collectively, an altered 3D genomic architecture of cortical neurons may regulate the gene networks associated with morphine effects. Our finding provides critical hubs connecting chromosome spatial organization and gene networks associated with the morphine effects in humans.

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