Consequences of Increases in Antibiotic Resistance Pattern on Outcome of Pancreatic Resection for Cancer

Abstract

Antimicrobial resistance is significantly associated with the risk of major non-infectious morbidity.

A rapid evidence assessment exploring whether antimicrobial resistance complicates non-infectious health conditions and healthcare services, 2010–20

“…Overall, 11 studies were identified that discussed the impacts of AMR on surgery. 10–18 These studies explored the impact on mortality, health outcomes, surgical success and length of stay in hospital.…”

“…The literature suggests that patients undergoing surgery are at risk of death if an antimicrobial-resistant infection develops. 10–12 In addition, surgical patients who develop a drug-resistant infection are at an increased risk of developing post-operative complications compared with those with drug-susceptible infections (e.g. visual impairment after eye surgery, surgical site infection, internal bleeding, fever for long periods, cardiac issues).…”

“…visual impairment after eye surgery, surgical site infection, internal bleeding, fever for long periods, cardiac issues). 10 , 11 , 13–17 The likelihood of the surgery having a successful outcome can also be negatively affected for surgical patients with resistant infections compared with those with drug-susceptible infections. 17 , 18 Finally, the one study found that patients undergoing orthopaedic surgery who develop a resistant infection require longer stays in hospital.…”

“…Overall, 10 studies explored the impacts of AMR on cancer patients, covering mortality, length of hospital stay, health outcomes and risk of AMR. 10 , 11 , 37 , 41–47 …”

“… 46 , 47 The literature was inconclusive as to the impact of AMR on length of hospital stay for cancer patients. 10 , 45 …”