Preliminary evidence of polymorphisms of cell cycle regulatory genes and their roles in urinary tract urothelial cancer susceptibility and prognosis in a Taiwan population

Lin, Ying‐Chu; Hour, Tzyh‐Chyuan; Tsai, Yu‐Chieh; Huang, Shu‐Pin; Wu, Wen‐Jeng; Chen, Chung‐Hsin; Pu, Yeong-Shiau; Chung, Shiu-Dong; Huang, Chao‐Yuan

doi:10.1016/j.urolonc.2016.08.001

Cited by 12 publications

(6 citation statements)

References 38 publications

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“…López-Cortés et al ( 50 ) carried out a study in 2018 to investigate the role of single nucleotide polymorphism AURKA T91A (rs2273535) in a high altitude Ecuadorian Mestizo population consisting of 100 patients and 100 controls, and found a significant relationship between the rs2273535 genotype and a higher risk of breast cancer development. This association was confirmed in different types of cancer, including hepatocellular carcinoma (HCC) by Bao et al ( 62 ) with 788 cases and 815 controls, urinary tract urothelial cancer by Lin et al ( 70 ) with 185 cases and 188 controls, gastric cancer by Zhou et al ( 51 ) with 381 cases and 468 controls, as well as other types of cancer. However, opposing results were also frequently reported.…”

Section: Discussionmentioning

confidence: 83%

“…Among these publications, 12 focused on breast cancer ( 39 – 50 ), 5 on gastric cancer ( 51 – 55 ), 3 on colorectal cancer ( 56 – 58 ), 2 on esophageal ( 59 , 60 ), 2 on liver cancer ( 61 , 62 ), and 2 on oral cancer ( 63 , 64 ). Moreover, there was only 1 study for each of the following cancers: lung cancer ( 65 ), neuroblastoma cancer ( 66 ), ovarian cancer ( 67 ), prostate cancer ( 68 ), renal cancer ( 69 ), urinary tract urothelial cancer ( 70 ), uterine cancer ( 71 ), bladder cancer ( 70 ), and endometrial cancer ( 72 ). As evident in Table 1 , among these case-control studies, 2 of them had low risk of bias, 31 had moderate risk of bias, while 3 had high risk of bias.…”

Section: Resultsmentioning

confidence: 99%

“…HCC) byBao et al (62) with 788 cases and 815 controls, urinary tract urothelial cancer by Lin et al(70) with 185 cases and 188 controls, gastric cancer by Zhou et al(51) with 381 cases and 468 controls, as well as other types of cancer. However, opposing results were also frequently reported.…”

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confidence: 99%

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AURKA rs2273535 T>A Polymorphism Associated With Cancer Risk: A Systematic Review With Meta-Analysis

Wang

Zhu

et al. 2020

Front. Oncol.

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Aurora kinase A (AURKA) is a cell cycle regulatory serine/threonine kinase that promotes cell cycle progression. It plays an important role in regulating the transition from G2 to M phase during mitosis. The association between the AURKA rs2273535 T>A polymorphism and cancer risk has been investigated, but the results remain inconsistent. To get a more accurate conclusion, we conducted a comprehensive meta-analysis of 36 case-control studies, involving 22,884 cancer cases and 30,497 healthy controls. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the association of interest. Pooled analysis indicated that the AURKA rs2273535 T>A polymorphism increased the overall risk of cancer (homozygous: OR = 1.17, 95% CI = 1.04-1.33; recessive: OR = 1.15, 95% CI = 1.05-1.25; allele: OR = 1.07, 95% CI = 1.02-1.13). Stratification analysis by cancer type further showed that this polymorphism was associated with an increased breast cancer risk. This meta-analysis indicated that the AURKA rs2273535 T>A polymorphism was associated with an overall increased cancer risk, especially breast cancer. Further validation experiments are needed to strengthen our conclusion.

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Section: Discussionmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

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AURKA rs2273535 T>A Polymorphism Associated With Cancer Risk: A Systematic Review With Meta-Analysis

Wang

Zhu

et al. 2020

Front. Oncol.

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“…Asian carriers of AURKA rs2273535 are at a high risk of breast cancer, but Caucasian carriers are not 18. AURKA rs2273535 may increase susceptibility to UTUC 19. Moreover, individuals who received alisertib for metastatic urothelial carcinoma, with the AA genotype of rs1047972 have longer progression-free survival compared with individuals with the wild-type TT genotype 20.…”

Section: Discussionmentioning

confidence: 99%

Impacts of AURKA Genetic Polymorphism on Urothelial Cell Carcinoma Development

Huang

Chen

et al. 2019

J. Cancer

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Urothelial cell carcinoma (UCC) is the most common primary malignancy of the urinary system and the second-most common type of renal cell carcinoma. Aurora kinase A (AURKA), a serine/threonine kinase, has a critical role in centrosome duplication, spindle assembly checkpoint, and cytokinesis. Here, we determined the correlation between UCC susceptibility and AURKA polymorphisms. We used real-time polymerase chain reaction to compare the genotype distributions and allelic frequencies of four single-nucleotide polymorphisms (SNPs) of AURKA , namely rs1047972, rs2273535, rs2064863, and rs6024836, between 431 UCC cases and 862 healthy controls. Logistic regression models demonstrated that the G allele of rs2064863, a genetic polymorphism of AURKA, exhibited a significant protective effect against UCC among the 862 nonsmokers. Moreover, patients with rs2064863 G allele exhibited a slightly lower risk of lymph node metastasis and those with rs6024836 G allele exhibited a lower risk of distant metastases. Our study suggested that several variants of AURKA SNPs rs2064863 and rs6024836 may serve as critical predictors for the clinical status of UCC.

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“…Recently, a large number of studies have investigated the association between TP53 codon 72 polymorphisms and BC, including mechanism research, cancer susceptibility and prognosis 22 , 44 , 51 . As reported by Kung, increased growth arrest and decreased apoptosis were found in R72 cells compared with P72 cells.…”

Section: Discussionmentioning

confidence: 99%

TP53 codon 72 Polymorphism and bladder cancer risk: a meta-analysis and emphasis on the role of tumor or smoking status

et al. 2018

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Background: Various studies had explored the relationship between TP53 codon 72 polymorphisms and the risk of bladder cancer (BC). However, their results remained inconsistent and the definite role of smoking or tumor status associated with this polymorphism in BC cases was seldom involved. Hence, this meta-analysis was to disclose such associations.Methods: Systematical and comprehensive retrieval of online databases PubMed, PMC, EMBASE and Web of Science were conducted to obtain eligible studies, up to May 30th, 2018. Pooled odds ratios (ORs) with 95% confidence intervals (CI) were utilized to assess the associations between TP53 codon 72 polymorphisms and BC susceptibilities under five genetic comparison models.Results: Ultimately, this meta-analysis enrolled 22 applicable studies with 3,791 BC cases and 4,917 controls. Our results suggested that the variant genotypes were associated with BC risk in Asian subgroup (allele model: OR=1.19, 95% CI=1.04-1.34; dominant model: OR=1.27, 95% CI=1.06-1.52; homozygote model: OR=1.36, 95% CI=1.03-1.80), while negative outcomes were presented in Caucasians. In the relationship between TP53 codon 72 polymorphisms and BC tumor stage in Asian group, positive results were presented in allele model: OR=1.68, 95% CI=1.04-2.72; dominant model: OR=2.46, 95% CI=1.08-5.61; heterozygous model: OR=2.32, 95% CI=1.04-5.14; homozygote model: OR=2.66, 95% CI=1.04-6.81. However, no evidence was revealed between this polymorphism and BC tumor grade. Besides, significant associations were displayed between TP53 codon 72 polymorphism and smoking status (allele model: OR=1.40, 95% CI=1.06-1.84; dominant model OR=1.72, 95% CI=1.18-2.50; heterozygous model: OR=1.77, 95% CI=1.19-2.64).Conclusion: Taken together, our results shed light on that TP53 codon 72 polymorphism was significantly associated with the susceptibility to BC in Asians. In addition, positive associations were also revealed between this polymorphism and tumor stage/smoking status in BC cases.

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Preliminary evidence of polymorphisms of cell cycle regulatory genes and their roles in urinary tract urothelial cancer susceptibility and prognosis in a Taiwan population

Cited by 12 publications

References 38 publications

AURKA rs2273535 T>A Polymorphism Associated With Cancer Risk: A Systematic Review With Meta-Analysis

AURKA rs2273535 T>A Polymorphism Associated With Cancer Risk: A Systematic Review With Meta-Analysis

Impacts of AURKA Genetic Polymorphism on Urothelial Cell Carcinoma Development

TP53 codon 72 Polymorphism and bladder cancer risk: a meta-analysis and emphasis on the role of tumor or smoking status

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