Resistance training as supportive measure in advanced cancer patients undergoing TKI therapy—a controlled feasibility trial

Abstract

NCT01645150.

The effects of resistance training on muscular strength and hypertrophy in elderly cancer patients: A systematic review and meta-analysis

“…In the quality assessment, 10 studies 22 − 25 , 27 , 28 , 30 − 33 reported appropriate generation of a random allocation sequence (77%), 4 studies 24 , 26 , 29 , 33 presented concealment of the allocation sequence (31%), 7 studies 21 , 23 , 24 , 26 , 29 , 32 , 33 described blinding of the assessment and collection outcomes (54%), all 13 studies explained proportion of participants lost to follow-up, all 13 studies exhibited complete outcome data, and 5 studies 23 , 25 , 27 , 30 , 33 reported that the intention-to-treat principle (39%) were used for statistical analyses. Egger's test showed no significant publication bias for both muscular strength and hypertrophy ( p = 0.08 and p = 0.17, respectively) ( Fig.…”

“…Eight studies reported that there were no adverse events. 23 , 26 − 32 One study reported that 3 patients discontinued the intervention due to knee or back pain. 24 Another study reported that 1 patient experienced chest pain during exercise and subsequent cardiologic investigations were negative.…”

“…Articles were published from May 2003 25 to June 2017. 26 A total of 717 participants completed their interventions (RT = 394, CON = 323; females = 33.5%); study cohorts ranged from 8 participants 23 to 155 participants. 25 The average age of the participants was 66.0 ± 7.3 years (RT: 66.4 ± 7.5 years; CON: 65.5 ± 7.0 years; mean ± SD).…”

“…BMI was 28.7 ± 4.3 kg/m 2 (RT: 28.6 ± 4.3 kg/m 2 ; CON: 28.9 ± 4.4 kg/m 2 ). Out of the 13 studies, 9 21 , 22 , 24 − 26 , 30 − 33 were conducted during adjuvant treatment (chemotherapy, radiation, and/or androgen deprivation therapy), whereas 4 23 , 27 − 29 were conducted after the completion of treatment.…”

“…All training consisted of 1–4 sets, 6–12 repetitions, and 8–10 exercises. The number of total sets per week ranged from 32 26 to 90, 32 and the number of total repetitions per week ranged from 384 26 to 990. 32 All trials established their intensity by percentage of 1-RM or 6–12-RM (a workload that enables the participant to complete 6–12 repetitions).…”