Efficacy of Early Enteral Immunonutrition on Immune Function and Clinical Outcome for Postoperative Patients With Gastrointestinal Cancer

Luo, Zhenzhen; Wang, Junxia; Zhang, Zhen; Li, Hong; Huang, Lan; Qiao, Ying; Wang, Dan; Huang, Jingjing; Guo, Luwei; Wang, Zhibin; Liu, Yanhua; Zhang, Yi

doi:10.1177/0148607117715439

Cited by 20 publications

(15 citation statements)

References 40 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A total of 216 titles and abstracts were screened, of which 60 were identified for full-text screening (Cohen's kappa = 0.9239). The updated search yielded 7 additional studies [44][45][46][47][48][49][50] Figure 2].…”

Section: Resultsmentioning

confidence: 99%

Enteral and parenteral nutrition in cancer patients, a comparison of complication rates: an updated systematic review and (cumulative) meta-analysis

Chow

Bruera

Arends

et al. 2019

Support Care Cancer

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Enteral and parenteral nutrition in cancer patients, a comparison of complication rates: an updated systematic review and (cumulative) meta-analysis

Chow

Bruera

Arends

et al. 2019

Support Care Cancer

View full text Add to dashboard Cite

show abstract

“…Se obtuvo consenso respecto al tiempo de administración así (21,25,26,29,47,48,53,65,(68)(69)(70)(71) : 1. En el preoperatorio se debe iniciar entre 5 y 7 días previos a la cirugía 2.…”

Section: ¿Cuánto Tiempo Previo a La Cirugía Se Debe Iniciar La Terapiunclassified

Inmunonutrición perioperatoria. Consenso de la Asociación Colombiana de Nutrición Clínica

Bermúdez¹,

Sanabria²,

Ayala³

et al. 2019

Rev. Nutr. Clin. Metab.

View full text Add to dashboard Cite

Introducción: la inmunonutrición es una alternativa en pacientes quirúrgicos por sus ventajas clínicas. Se pretende unificar conceptos y desarrollar un documento de acceso y consulta fácil en relación con el uso de inmunonutrición en pacientes quirúrgicos en Colombia. Metodología: se seleccionó un grupo interdisciplinario conformado por 21 expertos en nutrición clínica quienes, previa revisión de la literatura, participaron en la Reunión de Consenso. El análisis y la discusión se realizó en torno a 15 preguntas clasificadas en tres tipos: A. Fundamentos de la utilización de la inmunonutrición, B. Indicaciones, seguridad y beneficios de la inmunonutrición, C. Administración de la inmunonutrición. Resultados: entre los resultados que obtuvieron consenso se encuentran: el uso de inmunonutrientes como arginina, nucleótidos, glutamina, ácidos grasos omega-3, antioxidantes y simbióticos. La inmunonutrición tiene mayor beneficio en los pacientes quirúrgicos, los pacientes malnutridos que van a ser llevados a cirugía y que sufren trauma mayor y quemaduras graves. No se encontró beneficio de la inmunonutrición en pacientes bien nutridos que van a ser llevados a cirugía electiva, cardiaca, o en pacientes con sepsis severa. Se debe usar 5-7 días antes de la cirugía y hasta 10 días después, de preferencia por vía oral/enteral. Conclusión: existen recomendaciones para el uso de inmunonutrición que son ampliamente aceptadas, las cuales deben orientar la toma de decisiones y el uso de recursos en el sistema de salud colombiano.

show abstract

“…In addition to ensuring nitrogen balance and protein synthesis, the supply of immunonutrition can modulate the inflammatory response, counteract postoperative immune impairment, and improve clinical outcomes [12]. Some previous studies have indicated that perioperative immunonutrition support in patients undergoing elective gastrointestinal surgery could significantly modulate the inflammatory reaction, improve cellular immunity, and reduce postoperative infectious complications and length of hospital stay compared with that in patients fed standard nutrition [13][14][15][16]. Besides, both malnourished and well-nourished patients can benefit from immunonutrition [17].…”

Section: Introductionmentioning

confidence: 99%

Clinical Efficacy of Perioperative Immunonutrition Containing Omega-3-Fatty Acids in Patients Undergoing Hepatectomy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2020

View full text Add to dashboard Cite

Background: The effect of immunonutrition in patients undergoing hepatectomy remains unclear. This meta-analysis aimed to assess the impact of immunonutrition on postoperative clinical outcomes in patients undergoing hepatectomy. Methods: A literature search of PubMed, Cochrane Library, Web of Science, and Embase databases was performed to identify all randomized controlled trials (RCTs) exploring the effect of perioperative immunonutrition in patients undergoing hepatectomy until the end of March 10, 2020. Quality assessment and data extraction of RCTs were conducted independently by 3 reviewers. Mean difference (MD) and odds ratio (OR) with 95% confidence interval (CI) were calculated using a fixed-effects or random-effects model. The meta-analysis was performed with RevMan 5.3 software. Results: Nine RCTs involving a total of 966 patients were finally included. This meta-analysis showed that immunonutrition significantly reduced the incidences of overall postoperative complications (OR = 0.57, 95% CI: 0.34–0.95; p = 0.03), overall postoperative infectious complications (OR = 0.53, 95% CI: 0.37–0.75; p = 0.0003), and incision infection (OR = 0.50, 95% CI: 0.28–0.89; p = 0.02), and it shortened the length of hospital stay (MD = −3.80, 95% CI: −6.59 to −1.02; p = 0.007). There were no significant differences in the incidences of pulmonary infection (OR = 0.60, 95% CI: 0.32–1.12; p = 0.11), urinary tract infection (OR = 1.30, 95% CI: 0.55–3.08; p = 0.55), liver failure (OR = 0.54, 95% CI: 0.23–1.24; p = 0.15), and postoperative mortality (OR = 0.69, 95% CI: 0.26–1.83; p = 0.46). Conclusion: Given its positive impact on postoperative complications and the tendency to shorten the length of hospital stay, perioperative immunonutrition should be encouraged in patients undergoing hepatectomy.

show abstract

Efficacy of Early Enteral Immunonutrition on Immune Function and Clinical Outcome for Postoperative Patients With Gastrointestinal Cancer

Abstract: EEIN is superior to PN in improving nutrition status, enhancing immune function, and elevating quality of life.

Cited by 20 publications

References 40 publications

Enteral and parenteral nutrition in cancer patients, a comparison of complication rates: an updated systematic review and (cumulative) meta-analysis

Enteral and parenteral nutrition in cancer patients, a comparison of complication rates: an updated systematic review and (cumulative) meta-analysis

Inmunonutrición perioperatoria. Consenso de la Asociación Colombiana de Nutrición Clínica

Clinical Efficacy of Perioperative Immunonutrition Containing Omega-3-Fatty Acids in Patients Undergoing Hepatectomy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Contact Info

Product

Resources

About