Correlation between polymorphism of vitamin D receptor TaqI and susceptibility to colorectal cancer

Sheng, Shihou; Chen, Yahong; Shen, Zhen

doi:10.1097/md.0000000000007242

Cited by 10 publications

(11 citation statements)

References 32 publications

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“…There are several previous meta‐analyses on the role of rs731236 on CRC risk. Most of the previous meta‐analyses found no significant association between the risk of CRC and rs731236. While Serrano et al in their meta‐analysis found significant results based on analyzing both of colorectal cancer and adenoma.…”

Section: Discussionmentioning

confidence: 92%

MicroRNA‐binding site polymorphisms and risk of colorectal cancer: A systematic review and meta‐analysis

et al. 2019

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Genetic variations in miRNAs binding site might participate in cancer risk. This study aimed to systematically review the association between miRNA‐binding site polymorphisms and colorectal cancer (CRC). Electronic literature search was carried out on PubMed, Web of Science (WOS), Scopus, and Embase. All types of observational studies till 30 November 2018 were included. Overall 85 studies (21 SNPs) from two systematic searches were included analysis. The results showed that in the Middle East population, the minor allele of rs731236 was associated with decreased risk of CRC (heterozygote model: 0.76 [0.61‐0.95]). The minor allele of rs3025039 was related to increased risk of CRC in East Asian population (allelic model: 1.25 [1.01‐1.54]). Results for rs3212986 were significant in overall and subgroup analysis (P < .05). For rs1801157 in subgroup analysis the association was significant in Asian populations (including allelic model: 2.28 [1.11‐4.69]). For rs712, subgroup analysis revealed a significant (allelic model: 1.41 [1.23‐1.61]) and borderline (allelic model: 0.92 [0.84‐1.00]) association in Chinese and Czech populations, respectively. The minor allele of rs17281995 increased risk of CRC in different genetic models (P < .05). Finally, rs5275, rs4648298, and rs61764370 did not show significant associations. In conclusion, minor allele of rs3025039, rs3212986, and rs712 polymorphisms increases the risk of CRC in the East Asian population, and heterozygote model of rs731236 polymorphism shows protective effect in the Middle East population. In Europeans, the minor allele of rs17281995 may increase the risk of CRC, while rs712 may have a protective effect. Further analysis based on population stratifications should be considered in future studies.

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Section: Discussionmentioning

confidence: 92%

MicroRNA‐binding site polymorphisms and risk of colorectal cancer: A systematic review and meta‐analysis

et al. 2019

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“…The literature has shown correlations of these polymorphisms with several pathologies, such as osteoporosis, risk of fractures, diabetes, metabolic syndrome, Alzheimer's disease, asthma, multiple sclerosis, susceptibility to tuberculosis, and cancer [ 12 , 24 , 36 – 42 ]. The present study analyzed the presence of specific pathologies with the TaqI polymorphism frequency.…”

Section: Discussionmentioning

confidence: 99%

Association of Vitamin D with the TaqI Polymorphism of the VDR Gene in Older Women Attending the Basic Health Unit of the Federal District, DF (Brazil)

Freitas

Silva

Lima

et al. 2020

Journal of Aging Research

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Aging is accompanied by various functional modifications determined by their environment, lifestyle, nutrition, and genetics. Based on these factors, it is essential to verify the vitamin deficiency in the elderly population. Hypovitaminosis D is commonly present in human aging, increasing the chances of developing noncommunicable chronic diseases. The VDR gene TaqI polymorphism may modify the vitamin D metabolic pathway by altering the interaction between the vitamin D receptor and the active circulating vitamin D. Therefore, this study aimed to investigate the association between serum vitamin D and biochemical and genetic factors, considering the TaqI polymorphism of the VDR gene, in an elderly population of the Federal District. The study was a descriptive, case-control, quantitative, and cross-sectional type and was conducted in two basic health units in the administrative region of Ceilândia, Federal District, DF, Brazil, with women aged 60 years or older. Anthropometric, biochemical, and genetic parameters (VDR TaqI polymorphism) were evaluated. The adopted significance level was 5%, and statistical analyses were performed using the SPSS version 20.0 program. The study consisted of 128 participants. The most prevalent age was from 60 to 65 years (N = 53; 41.4%). 66 elderly (51.6%) were part of the case group (hypovitaminosis D), while 62 were in the control group. In the case group, 30.2% had grade I obesity, 77.3% were hypertensive, and 51.5% were diabetic. The TT genotype was present in 47% of the case group and 54.8% in the control group (p=0.667). There was no association between serum vitamin D levels and the VDR gene variant TaqI polymorphism in an elderly Brazilian population.

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“…GSTM1 and GSTT1 null genotypes increased risk of CRC in Caucasian populations [ 103 , 104 , 105 ]. Polymorphisms in vitamin D receptor ( VDR ) gene, in combination with dietary fat or calcium, seem to also modulate CRC risk, but controversial results have been found [ 106 , 107 , 108 , 109 ]. The common Thr1482Ile polymorphism in the transient receptor potential melastatin 7 ( TRPM7 ), a ubiquitously expressed constitutive ion channel with higher affinity for Mg2+ than for Ca2+, was associated with an elevated risk of both adenomatous and hyperplastic polyps.…”

Section: Nutrition and Colorectal Cancermentioning

confidence: 99%

Precision Nutrition for Targeting Lipid Metabolism in Colorectal Cancer

2017

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Cancer is a multistage and multifactorial condition with genetic and environmental factors modulating tumorogenesis and disease progression. Nevertheless, cancer is preventable, as one third of cancer deaths could be avoided by modifying key risk factors. Nutrients can directly affect fundamental cellular processes and are considered among the most important risk factors in colorectal cancer (CRC). Red and processed meat, poultry consumption, fiber, and folate are the best-known diet components that interact with colorectal cancer susceptibility. In addition, the direct association of an unhealthy diet with obesity and dysbiosis opens new routes in the understanding of how daily diet nutrients could influence cancer prognosis. In the “omics” era, traditional nutrition has been naturally evolved to precision nutrition where technical developments have contributed to a more accurate discipline. In this sense, genomic and transcriptomic studies have been extensively used in precision nutrition approaches. However, the relation between CRC carcinogenesis and nutrition factors is more complex than originally expected. Together with classical diet-nutrition-related genes, nowadays, lipid-metabolism-related genes have acquired relevant interest in precision nutrition studies. Lipids regulate very diverse cellular processes from ATP synthesis and the activation of essential cell-signaling pathways to membrane organization and plasticity. Therefore, a wide range of tumorogenic steps can be influenced by lipid metabolism, both in primary tumours and distal metastasis. The extent to which genetic variants, together with the intake of specific dietary components, affect the risk of CRC is currently under investigation, and new therapeutic or preventive applications must be explored in CRC models. In this review, we will go in depth into the study of co-occurring events, which orchestrate CRC tumorogenesis and are essential for the evolution of precision nutrition paradigms. Likewise, we will discuss the application of precision nutrition approaches to target lipid metabolism in CRC.

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Correlation between polymorphism of vitamin D receptor TaqI and susceptibility to colorectal cancer

Cited by 10 publications

References 32 publications

MicroRNA‐binding site polymorphisms and risk of colorectal cancer: A systematic review and meta‐analysis

MicroRNA‐binding site polymorphisms and risk of colorectal cancer: A systematic review and meta‐analysis

Association of Vitamin D with the TaqI Polymorphism of the VDR Gene in Older Women Attending the Basic Health Unit of the Federal District, DF (Brazil)

Precision Nutrition for Targeting Lipid Metabolism in Colorectal Cancer

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