MicroRNA‐binding site polymorphisms and risk of colorectal cancer: A systematic review and meta‐analysis

Abstract

Genetic variations in miRNAs binding site might participate in cancer risk. This study aimed to systematically review the association between miRNA‐binding site polymorphisms and colorectal cancer (CRC). Electronic literature search was carried out on PubMed, Web of Science (WOS), Scopus, and Embase. All types of observational studies till 30 November 2018 were included. Overall 85 studies (21 SNPs) from two systematic searches were included analysis. The results showed that in the Middle East population, the minor allele of rs731236 was associated with decreased risk of CRC (heterozygote model: 0.76 [0.61‐0.95]). The minor allele of rs3025039 was related to increased risk of CRC in East Asian population (allelic model: 1.25 [1.01‐1.54]). Results for rs3212986 were significant in overall and subgroup analysis (P < .05). For rs1801157 in subgroup analysis the association was significant in Asian populations (including allelic model: 2.28 [1.11‐4.69]). For rs712, subgroup analysis revealed a significant (allelic model: 1.41 [1.23‐1.61]) and borderline (allelic model: 0.92 [0.84‐1.00]) association in Chinese and Czech populations, respectively. The minor allele of rs17281995 increased risk of CRC in different genetic models (P < .05). Finally, rs5275, rs4648298, and rs61764370 did not show significant associations. In conclusion, minor allele of rs3025039, rs3212986, and rs712 polymorphisms increases the risk of CRC in the East Asian population, and heterozygote model of rs731236 polymorphism shows protective effect in the Middle East population. In Europeans, the minor allele of rs17281995 may increase the risk of CRC, while rs712 may have a protective effect. Further analysis based on population stratifications should be considered in future studies.

Association analysis of miRNA-related genetic polymorphisms in miR-143/145 and KRAS with colorectal cancer susceptibility and survival

“…It is propsosed that mutations in either miRNAs or their coexpressed miRNA binding sites are often deleterious, which can affect miRNA/target gene interaction, resulting in differential mRNA or protein expression and increased susceptibility to common diseases [17]. This view was supported by some studies of miRNA-related genetic alterations with different types of cancer, including CRC [18][19][20]. However, published evidences for genetic variations of miR-143/145 and the 3′UTR of KRAS with CRC susceptibility are limited and not comprehensively investigated.…”

The Importance of SNPs at miRNA Binding Sites as Biomarkers of Gastric and Colorectal Cancers: A Systematic Review

“…In previous systematic research, studies were included with bioinformatics prediction and weak confirmation, while we determined the minimal criteria for inclusion research. Gholami and colleagues characterized SNPs in miRNA binding sites in colorectal cancer risk, while we engaged these biological markers in various gastrointestinal carcinoma [ 36 ]. They performed a merged systematic review and meta-analysis that included 85 research studies obtained from two previous systematic reviews about miRs-binding to SNP sites in colorectal carcinoma susceptibility.…”

Association analysis of miRNA-related genetic polymorphisms in miR-143/145 and KRAS with colorectal cancer susceptibility and survival

“…Mutations in either miRNAs or their co-expressed miRNA binding sites are often deleterious, which can affect miRNA/target gene interaction, resulting in differential mRNA or protein expression and increased susceptibility to common diseases [17]. This view was supported by some studies of miRNA-related genetic alterations with different types of cancer, including CRC [18][19][20]. However, published evidence for genetic variations of miR-143/145 and the 3 UTR of KRAS with CRC susceptibility are limited and not comprehensively investigated.…”