25 (OH) D3 levels, incidence and recurrence of different clinical forms of benig paroxysmal positional vertigo

Maslovara, Siniša; Soldo, Silva Butković; Šestak, Anamarija; Milinkovic, Katarina; Rogic-Namacinski, Jasna; Soldo, Anamarija

doi:10.1016/j.bjorl.2017.05.007

Cited by 35 publications

(24 citation statements)

References 31 publications

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“…After further evaluation of remaining 99 full-text studies, sixty eligible studies with 36 646 patients were finally included in this meta-analysis. 9-12,13,16,18,22-78 A PRISMA flow diagram were presented to describe the detail selection process (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Risk Factors for the Recurrence of Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis

Wang

Liu

et al. 2020

Ear Nose Throat J

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Objective: Benign paroxysmal positional vertigo (BPPV) has a high recurrence rate, but the risk factor–associated recurrence are elusive. Methods: Searches were performed in PubMed, Embase, Cochrane library, Web of science, Chinese National Knowledge Infrastructure, and Sino Med up to November 3, 2019. The effect size was analyzed by odds ratio and 95% CI. Data from eligible studies were meta-analyzed using Stata version 15.0. Results: Our search resulted in a total of 4076 hits. Twenty-four outcomes of sixty articles were included in the meta-analysis. Risk factors for the recurrence of BPPV included female gender, age (≥65years), hyperlipidemia, diabetes, hypertension, migraine, cervical spondylosis, osteopenia/osteoporosis, head trauma, otitis media, abnormal vestibular evoked myogenic potential, and long use of computers. No significant differences were found in side, type of the involved semicircular canals, smoking, alcohol consumption, stroke, ear surgery, duration of vertigo before treatment, the times of repositioning, Meniere disease, sleep disorders, hypercholesterolemia, and 25-hydroxy vitamin D. Conclusion: These findings strengthen clinical awareness of early warning to identify patients with potential relapse risk of BPPV and clinicians should counsel patients regarding the importance of follow-up after diagnosis of BPPV.

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Section: Resultsmentioning

confidence: 99%

Risk Factors for the Recurrence of Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis

Wang

Liu

et al. 2020

Ear Nose Throat J

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“…Instead, it has been proposed that a third disorder, namely vitamin D deficiency, may be contributing to the development of both conditions 6,7 and we have proposed a mechanistic conceptual model for this relationship 8 . In addition to its well-known roles in bone biology and osteoporosis 9 , decreased vitamin D has also been associated with a variety of other conditions 9 , most recently idiopathic BPPV 4,6–8,10–14 , particularly in the recurrent disease 6,10,15,16 . It has been argued that the prevalence of osteoporosis and vitamin D deficiency in the general population is high and therefore that the coexistence of BPPV with osteoporosis and vitamin D deficiency may be purely coincidental 17 .…”

Section: Introductionmentioning

confidence: 99%

A Relationship Between Blood Levels of Otolin-1 and Vitamin D

Parham¹,

Kuchel²,

McElhaney

et al. 2018

Otology &Amp; Neurotology

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Our results demonstrate a relationship between vitamin D and otolin-1. The majority of our subjects had abnormally low vitamin D levels, but only those over 70 years of age showed a negative correlation with high otolin-1 levels. We postulate that a seasonal drop in vitamin D may not be sufficient for otoconia fragmentation and ultimately iBPPV, rather, chronically low vitamin D maybe required to induce otoconia degeneration.

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“…[34] In severe vitamin D deficiencies, improvement of serum vitamin D levels was shown to diminish the recurrence rate of BPPV. [32] On the contrary, Maslovara et al [35] indicated the need for supplemental therapy due to a low level of serum vitamin D3 in most BPPV patients participating in their study, although no significant difference was shown in vitamin D3 levels in patients with and without recurrence. Future studies should be focused on clarifying the effect of vitamin D supplementation in decreasing recurrence rates in patients with recurrent BPPV.…”

Section: Vitamin D and Otolaryngological Diseasesmentioning

confidence: 87%

The Role Of Vitamin D In Otolaryngological Diseases: Myth Or Truth

Bayram¹

2018

ENT Updates

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In the present review, we aimed to evaluate the role of vitamin D in otolaryngological diseases. Since the recognition of vitamin D as a steroid hormone, it has attracted clinicians as a research issue due to its unique and complicated functions in human body processes. Numerous studies have investigated the association between vitamin D and human diseases, including in the otolaryngological field. However, although vitamin D alterations may theoretically be involved in the pathogenesis of several otolaryngological diseases, a clear association has not been demonstrated due to inconsistent results from the studies to date. Further randomized controlled trials with large patient populations are required to determine the exact role of vitamin D in otolaryngological diseases.

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25 (OH) D3 levels, incidence and recurrence of different clinical forms of benig paroxysmal positional vertigo

Abstract: There were no significant differences in the vitamin D3 serum level in patients with and without recurrence. The study showed a low level of serum vitamin D3 in most patients, indicating the need for supplemental therapy.

Cited by 35 publications

References 31 publications

Risk Factors for the Recurrence of Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis

Risk Factors for the Recurrence of Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis

A Relationship Between Blood Levels of Otolin-1 and Vitamin D

The Role Of Vitamin D In Otolaryngological Diseases: Myth Or Truth

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