Development of a semi-quantitative risk assessment model for evaluating environmental threat posed by the three first EU watch-list pharmaceuticals to urban wastewater treatment plants: An Irish case study

Tahar, Alexandre; Tiedeken, Erin Jo; Clifford, Eoghan; Cummins, Enda; Rowan, Neil J.

doi:10.1016/j.scitotenv.2017.05.227

Cited by 31 publications

(11 citation statements)

References 46 publications

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“…Since the environmental assessment evidenced risks classified into three categories, namely low (i.e., atenolol, carbamazepine, erythromycin, metformin, and naproxen), low/medium (i.e., diclofenac and ibuprofen), and high (i.e., clarithromycin, estradiol, estrone, and sulfamethoxazole), in all samples, and the risk increased progressively in rural, periurban, and urban areas, we could use those data to make PhC prioritizations and, consequently, to address correction actions and serve as a guide for future ecotoxicological research [53,[89][90][91][92]. According to our results, Grill et al [59] predicted high ecotoxicological risk for 2 out of 15 PhCs (i.e., ethinylestradiol and azithromycin).…”

Section: Discussionmentioning

confidence: 99%

Predicted and Measured Concentration of Pharmaceuticals in Surface Water of Areas with Increasing Anthropic Pressure: A Case Study in the Coastal Area of Central Italy

Cardini

Pellegrino

Ercoli

2021

Water

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This study investigated the occurrence of 12 pharmaceuticals (PhCs) in surface water in Central Italy, aiming to improve the estimation of the predicted environmental concentration (PEC) by normalizing the loads to the number of inhabitants of the drainage system in rural, periurban, and urban areas. We performed two sampling campaigns assessing the concentration of PhCs (measured environmental concentration (MEC)) in surface water and in effluent from a wastewater treatment plant. The reliability of PEC calculated by the refined formula was assessed and compared to the ratio obtained by the unrefined formula. MECs of diclofenac, estradiol, estrone, ibuprofen, metformin, naproxen, sulfamethoxazole, atenolol, carbamazepine, and dehydro-erythromycin were significantly higher in urban than in periurban and rural areas, and increases were 12-, 3600-, 256-, 33-, 18-, 120-, 10-, 5-, 2-, and 1-fold, respectively. Refinement of PEC improved estimation of PhC concentrations for all areas, especially for the urban one. The environmental risk was predicted as low for atenolol, carbamazepine, erythromycin, metformin, and naproxen; low/medium for diclofenac and ibuprofen; and high for clarithromycin, estradiol, estrone, and sulfamethoxazole. Overall, the highest risk was posed by PhCs in effluent, while a progressively decreasing risk was estimated for urban, periurban, and rural areas.

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Section: Discussionmentioning

confidence: 99%

Predicted and Measured Concentration of Pharmaceuticals in Surface Water of Areas with Increasing Anthropic Pressure: A Case Study in the Coastal Area of Central Italy

Cardini

Pellegrino

Ercoli

2021

Water

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“…The presence of micropollutants represents a strong problem, but also an important opportunity to face and modify some human behavior. The interest related to the presence of micropollutant is due to the fact that, after being excreted in sewers by human body (as parent compounds or as metabolites), they firstly enter the wastewater treatment plants (WWTPs) and then surface water bodies, since WWTPs are generally not able to effectively remove them [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Factors Affecting Spatial and Temporal Concentration Variability of Pharmaceuticals: Comparison between Two WWTPs

et al. 2017

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Abstract:The presence of emerging organic micropollutants (such as pharmaceuticals) in sewage has been, for a long time, an issue of great concern within the international scientific debate. This item represents one of the main challenges related to a sustainable development, with particular concern to the public health control. While most of the work has been concentrated on their detection and the evaluation of their average level, little is known about the spatial and temporal variability of concentrations of these compounds in the effluent and its capability to affect the concentrations in time of the receiving water body. In this study, three sampling campaigns were carried out at two different wastewater treatment plants (WWTPs) in Varese area (Northern Italy) with the aim of monitoring the occurrence of some pharmaceuticals to evaluate their removal efficiency. The detected pharmaceuticals were: Ofloxacin, Ibuprofen, Atenolol, Bezafibrate, Carbamazepine, Salbutamol, Cyclophosphamide and Hydrochlorothiazide. The results obtained, together with the analysis of the characteristics of the chemicals and of the two WWTPs, allowed evaluating the factors affecting the spatial and temporal concentration variability in effluent waters and the potential influence of this variability in driving the exposure of the aquatic ecosystems in the receiving water body.

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“…In Germany, concentrations have reached levels of 2550 ng L À1 , which is higher than the annual average annual environmental quality standard (AA EQS) threshold concentration (100 ng L À1 ) for diclofenac. 5 The hazards associated with diclofenac have met the criteria for a priority substance which requires mandatory testing in surface waters. 31 Venlafaxine and its metabolite desvenlafaxine are prescription serotonin and norepinephrine reuptake inhibitor antidepressants.…”

Section: Selection Of Pharmaceuticalsmentioning

confidence: 99%

“…3,4 The increasing use of pharmaceuticals, coupled with the unknown ecological impact of pre-existing and novel active pharmaceutical ingredients (APIs), has led to increased concern. 5 Direct and indirect effects are exerted at or even below the measured environmental concentrations (MEC) in surface water. 6 Direct effects include the biochemical interaction with receptor molecules (e.g.…”

Section: Introductionmentioning

confidence: 99%

A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic

et al. 2021

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Development of a semi-quantitative risk assessment model for evaluating environmental threat posed by the three first EU watch-list pharmaceuticals to urban wastewater treatment plants: An Irish case study

Cited by 31 publications

References 46 publications

Predicted and Measured Concentration of Pharmaceuticals in Surface Water of Areas with Increasing Anthropic Pressure: A Case Study in the Coastal Area of Central Italy

Predicted and Measured Concentration of Pharmaceuticals in Surface Water of Areas with Increasing Anthropic Pressure: A Case Study in the Coastal Area of Central Italy

Factors Affecting Spatial and Temporal Concentration Variability of Pharmaceuticals: Comparison between Two WWTPs

A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic

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