Gastric emptying after artificial ulceration in rats: differences due to the site of the ulcer and the effects of prokinetic drugs

Uchida, Masayuki; Kobayashi, Orie; Shimizu, Kimiko

doi:10.1540/jsmr.53.48

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…60 An estimated 30%-50% of patients with FD have motor disorders, such as delayed GE and impaired gastric accommodation after a meal. 61 Although GE is delayed by gastric ulcers and diabetic mellitus, 62,63 it is important to ameliorate abnormal stress-induced GE in patients with FD.…”

Section: Discussionmentioning

confidence: 99%

Effects of Moxibustion on Stress-Induced Delayed Gastric Emptying via Somatoautonomic Reflex in Rats

Taniguchi

Ogasawara

et al. 2020

Medical Acupuncture

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Objective: Moxibustion (MOX) is used to treat a wide variety of disorders, including those with gastric symptoms. However, the exact mechanisms underlying the beneficial effects of MOX are unknown. The purpose of this study was to investigate if application of indirect MOX (iMOX) to ST 36 reduces restraint stress (RS)-induced alteration in gastric responses of conscious rats, and if a somatoautonomic reflex mediates gastric emptying (GE). Materials and Methods: One group of rats was fed solid food after 24 hours of fasting. Immediately after food ingestion. These rats were subjected to RS. Ninety minutes after feeding, the rats were euthanized, and their gastric contents were removed to calculate GE. iMOX had been performed at ST 36 bilaterally throughout the stress loading. To investigate if vagal-nerve activity was involved in mediating the stress-induced alterations of GE by iMOX, atropine was intraperitoneally administered to other rats just before initiating RS; bilateral truncal vagotomy had been performed on day 14 before GE measurement. Results: RS delayed GE significantly (42.9 -5.8%)in stressed rats, compared to nonstressed rats (68.7 -1.8%). iMOX at ST 36 reduced stress-induced inhibition of GE significantly (67.1 -2.4%). MOX-mediated reduction of GE disappeared upon atropine injection and vagotomy. Conclusions: RS-induced delayed GE may be ameliorated by iMOX at ST 36. Somatoautonomic, reflexinduced vagal-nerve activity helps mediate the stimulatory effects of iMOX on RS-induced delayed GE. As a complementary and alternative medicine, iMOX may also be advantageous for patients with gastric disorders, such as functional dyspepsia.

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Section: Discussionmentioning

confidence: 99%

Effects of Moxibustion on Stress-Induced Delayed Gastric Emptying via Somatoautonomic Reflex in Rats

Taniguchi

Ogasawara

et al. 2020

Medical Acupuncture

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“…Such ulcerative lesions can be acute or chronic and most often appear in any portion of the gastrointestinal tract exposed to the aggressive action of peptic acid. [3][4][5] Several drugs have been used in the treatment of gastric and duodenal ulcers, with gastric antisecretory agents such as H2-type histaminergic receptor antagonists 6 being of great importance protons such as omeprazole and lansoprazole. 7 Maytenus ilicifolia belongs to the Celastraceae family, contains 98 genus and approximately 1264 species found mainly in tropical regions (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Development of effervescent medical powder containing Maytenus ilicifolia extract Mart. ex Reissek for treatment of gastric disorders

Paulino¹,

Vieira²,

Braga³

et al. 2019

Int J Phytocos Nat Ingred

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Brazil is the country with the biggest biodiversity on the planet, but it does not avail itself enough of this potential to produce herbal medicines. Maytenus ilicifolia Mart. Ex Reissek is popularly known as "Espinheira-Santa" and in Brazil is widely used in popular medicine to treat a number of diseases such as gastritis and dyspepsia, and also displays laxative, diuretic, analgesic, antiseptic and healing properties and antineoplastic and antimicrobial activities. Among the reasons that hinder a better exploration of such biodiversity, the absence of an innovative culture draws a lot of attention, besides the inherent difficulties in the characteristics of the research and the development of this product modality. The aim of this study was developing an effervescent powder containing medicinal extract of M. ilicifolia. The methodologies to determine quality of the plant and extract including the organoleptic characteristics, the moisture content and volatiles, total ashes, extractive content, pH, and the bulk density. In our experiments, we demonstrated that the plant has been identified and has displayed the appropriate organoleptic characteristics to the preparation of the extract; we also demonstrated that the extract has been incorporated into a formulation that maintained its organoleptic characteristics, pH and content, as well as the formation of stable gases. With these experiments, we demonstrate for the first time that the developed formulation can serve as a prototype for the development of pharmaceutics effervescent product containing standardized extract of M. ilicifolia.

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Gastric emptying after artificial ulceration in rats: differences due to the site of the ulcer and the effects of prokinetic drugs

Cited by 2 publications

References 16 publications

Effects of Moxibustion on Stress-Induced Delayed Gastric Emptying via Somatoautonomic Reflex in Rats

Effects of Moxibustion on Stress-Induced Delayed Gastric Emptying via Somatoautonomic Reflex in Rats

Development of effervescent medical powder containing Maytenus ilicifolia extract Mart. ex Reissek for treatment of gastric disorders

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