Distant metastases in head and neck cancer

Duprez, Frédéric; Berwouts, Dieter; Neve, Wilfried De; Bonte, Katrien; Boterberg, Tom; Deron, Philippe; Huvenne, Wouter; Rottey, Sylvie; Mareel, Marcus

doi:10.1002/hed.24687

Cited by 193 publications

(161 citation statements)

References 33 publications

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“…In total, 20 (19%) patients developed distant metastasis, while only half of these patients developed a loco-regional recurrence, indicating early development of occult metastasis. The prevalence of distant metastasis seems somewhat higher in our series than in other studies, being 8% to 13.7% [27][28][29]. Duprez et al reported a 2and 5-year actuarial rates of distant control of 84% and 80% in a cohort of 1022 patients with HNSCC [29].…”

Section: Disease Controlcontrasting

confidence: 60%

Clinical outcome and toxicity after simultaneous integrated boost IMRT in head and neck squamous cell cancer patients

et al. 2019

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Introduction: A simultaneous integrated boost (SIB) intensity modulated radiotherapy (IMRT) in patients with head and neck squamous cell carcinoma (HNSCC) allows to irradiate different target volumes to different dose levels within a single treatment session without increasing the toxicity. Aim: To analyze the outcome and toxicity of patients treated by definitive or postoperative SIB IMRT for HNSCC. Material and methods: 106 patients with HNSCC of the oral cavity (OC), oropharynx (OP), larynx (L) and hypopharynx (HP), consecutively treated at our cancer center between 3/2012 and 3/2014 were retrospectively analyzed. The prescribed SIB IMRT doses were in the postoperative setting (group A) 60-66 Gy and 53 Gy in 30-33 fractions for PTV high risk and PTV elective, respectively; and 70 Gy and 56 Gy in 35 fractions for PTV high risk and PTV elective, respectively when given as primary treatment (group B). Toxicity was consistently graded according to RTOG/EORTC scale. Results: Median follow-up duration was 31 months. Thirty (28%) patients were postoperatively irradiated (group A) and 76 (72%) patients received definitive IMRT (group B). At 3 years, loco-regional control, distant control and overall survival were 78%, 78%, 57% and 64%, 76%, 52% in the postoperative (group A) and the definitive SIB IMRT group (group B), respectively. The observed acute grade 3 toxicities were dysphagia (44%), oral and/or oropharyngeal mucositis (40%) and dermatitis (21%). Late toxicity was predominantly clinically significant xerostomia (42%), dysgeusia (23%) and dysphagia (8%). Conclusion: SIB IMRT is feasible, safe and effective in the treatment of HNSCC patients.

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Section: Disease Controlcontrasting

confidence: 60%

Clinical outcome and toxicity after simultaneous integrated boost IMRT in head and neck squamous cell cancer patients

et al. 2019

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“…Primary tumors that metastasize to the thyroid are often found in the lungs or kidneys [12]. Since distant metastases of head and neck cancers are commonly found in the lungs, bone, liver, and skin, in decreasing order of frequency, metastasis to the thyroid gland is extremely rare [13]. Among the head and neck cancers, nasopharyngeal carcinoma is the most commonly reported primary lesion that metastasizes to the thyroid gland [4,14,15].…”

Section: Discussionmentioning

confidence: 99%

“…OSCC metastasis to the thyroid gland is a distant metastasis, and the current case was stage IVb T4aN2cM1, according to the tumor-node-metastasis classification. The prognosis of HNSCC with distant metastasis is generally poor [13]; however, compared with HPV-negative OSCC, control of the distant metastatic lesions is reportedly better in HPV-positive OSCC cases [13,18]. Nonetheless, whether the prognosis of HPV-positive OSCC with thyroid gland metastasis is good remains unknown.…”

Section: Discussionmentioning

confidence: 99%

A case report of thyroid metastasis from p16-positive oropharyngeal squamous cell carcinoma

Takenobu¹,

Moritani²,

Yoshioka³

et al. 2018

Endocr J

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Abstract. Thyroid metastasis from head and neck squamous cell carcinoma (SCC) is a very rare form of rarely observed metastatic thyroid tumor. We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right side with multiple lymph node metastases and a thyroid mass, which was determined as metastatic p16-positive OSCC by immunohistochemistry of specimens collected by fine-needle aspiration cytology (FNAC). He received one cycle of induction chemotherapy followed by concurrent chemoradiotherapy. No visible primary lesions were observed after treatment. The disappearance of the tonsillar lesion was considered to be a complete response by the magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT). The thyroid lesion was also decreased, but a solid lesion with unclear boundaries in the right thyroid lobe remained. Therefore, the patient underwent total thyroidectomy to remove any residual tumor. Postoperative pathological evaluation revealed no residual viable carcinoma cells in the resected specimen. As illustrated in this case, immunohistochemistry of the FNAC specimen for p16 was successful in determining the thyroid tumor as a metastatic lesion from the oropharynx. Although radical radiotherapy might be sufficient to control thyroid gland metastasis of OSCC, in this case, early-stage remedial surgery was thought to be necessary for a secure radical cure.

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“…Clinical or pathologic stage is valuable for predicting the prognosis of patients with OSCC. However, the survival outcomes can be quite different even for patients with same stage cancer . We have tried to uncover the role of serum markers in the prediction of survival in patients with OSCC.…”

Section: Discussionmentioning

confidence: 99%

“…However, the survival outcomes can be quite different even for patients with same stage cancer. 17,18 We have tried to uncover the role of serum markers in the prediction of survival in patients with OSCC. Previously, we found that higher serum lipid Lp (a) was associated with poorer overall survival.…”

Section: Discussionmentioning

confidence: 99%

Serum bilirubin level predicts postoperative overall survival in oral squamous cell carcinoma

Zhang

Zhu

et al. 2018

J Oral Pathology Medicine

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Distant metastases in head and neck cancer

Abstract: Distant metastases in head and neck cancer led to dismal prognosis. Factors associated with distant metastasis are related to characteristics of the primary tumor. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1733-1743, 2017.

Cited by 193 publications

References 33 publications

Clinical outcome and toxicity after simultaneous integrated boost IMRT in head and neck squamous cell cancer patients

Clinical outcome and toxicity after simultaneous integrated boost IMRT in head and neck squamous cell cancer patients

A case report of thyroid metastasis from p16-positive oropharyngeal squamous cell carcinoma

Serum bilirubin level predicts postoperative overall survival in oral squamous cell carcinoma

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