Serum bilirubin level predicts postoperative overall survival in oral squamous cell carcinoma

Zhang, Hongchuan; Li, Gang; Zhu, Zaiou; Zheng, Yang; Wu, Yunong; Zhang, Wei; Gu, Ning; Wang, Xiang; Song, Xiaomeng

doi:10.1111/jop.12693

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…This is the first large-scale study to report that low SB is associated with HNC. The inverse association between SB and LC noted in our study replicates the results of other studies on SB and LC [7][8][9][10][11] . A potential mechanism for this inverse association is likely through the antioxidant and anti-inflammatory action of SB on known cancer-promoters such as reactive oxygen species and inflammatory factors 25--27 .…”

Section: Discussionsupporting

confidence: 92%

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Interplay Of Serum Bilirubin and Tobacco Smoking with Lung and Head and Neck Cancers in a Diverse, EHR-linked Los Angeles Biobank

Venkateswaran,

Petter,

Boulier

et al. 2023

Preprint

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Structured AbstractBackgroundBilirubin is a potent antioxidant with a protective role in many diseases. We examined the relationships between serum bilirubin (SB) levels, tobacco smoking (a known cause of low SB), and aerodigestive cancers, grouped as lung (LC) and head and neck (HNC).MethodsWe examined the associations between SB, LC and HNC using data from 393,210 participants from UCLA Health, employing regression models, propensity score matching, and polygenic scores.ResultsCurrent tobacco smokers showed lower SB (-0.04mg/dL, 95% CI: [-0.04, -0.03]), compared to never-smokers. Lower SB levels were observed in HNC and LC cases (-0.10 mg/dL, [-0.13, -0.09] and -0.09 mg/dL, CI [-0.1, -0.07] respectively) compared to cancer-free controls with the effect persisting after adjusting for smoking. SB levels were inversely associated with HNC and LC risk (ORs per SD change in SB: 0.64, CI [0.59,0.69] and 0.57, CI [0.43,0.75], respectively). Lastly, a polygenic score (PGS) for SB was associated with LC (OR per SD change of SB-PGS: 0.71, CI [0.67, 0.76]).ConclusionsLow SB levels are associated with an increased risk of both HNC and LC, independent of the effect of tobacco smoking with tobacco smoking demonstrating a strong interaction with SB on LC risk. Additionally, genetically predicted low SB (from polygenic scores) is negatively associated with LC.ImpactThese findings suggest that SB could serve as a potential early biomarker for LC and HNC.

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Section: Discussionsupporting

confidence: 92%

“…Low SB levels are associated with increased risk of diseases including cancers, metabolic and cardiovascular diseases 4,5,6 . Additionally, low SB levels have been associated with poorer survival and worse prognosis in lung and oral cancers although these thresholds vary between studies and the type of bilirubin measured 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Interplay Of Serum Bilirubin and Tobacco Smoking with Lung and Head and Neck Cancers in a Diverse, EHR-linked Los Angeles Biobank

Venkateswaran,

Petter,

Boulier

et al. 2023

Preprint

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“…We have been committed to discover suitable serum biomarkers in prediction of clinical outcomes of patients with OSCC. In our previous studies, higher pre‐operative lipoprotein (α) (≥300 mg/L) and lower direct bilirubin (<4.0 μM) were found to be associated with adverse survival time. Recent studies have revealed that serum or salivary ADA levels might be useful in the follow‐up and diagnosis of head and neck carcinomas, which was only based on increased serum ADA levels in OSCC groups as compared to those in healthy individuals.…”

Section: Discussionmentioning

confidence: 90%

Prognostic value of serum liver enzymes in oral and oropharynx squamous cell carcinomas

Zhu

Zhou

Xiong

et al. 2018

J Oral Pathology Medicine

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Background: Serum liver enzymes, which catalyze relevant catabolic pathways, have been indicated to be diagnostic and prognostic tools for several malignant tumors.The correlation between serum liver enzymes levels and survival in patients with oral and oropharynx squamous cell carcinomas (OSCC) is still absent. Here, we conducted a study focusing on predictive value of serum liver enzymes in terms of prognosis in the patients. Methods:A retrospective study including 134 OSCC patients from years 2009 to 2014 was performed to investigate the association between levels of pre-treatment serum liver enzymes, various clinical parameters and prognostic outcomes, which are overall survival (OS) and disease-free survival (DFS). Log-rank tests with Kaplan-Meier method were used to detect potential prognostic biomarkers. Multivariate analyses by Cox proportional hazards model were used to identify significant predictors of prognosis.Results: Serum adenosine deaminase (ADA) level was associated with patients' OS and DFS by univariate analyses (P = 0.006 and P = 0.024, respectively). Multivariate analyses showed that higher serum ADA (>17.2 U/L) (P = 0.019) as well as positive lymph node status (P = 0.035) independently predicted worse OS of patients with OSCC. In addition, older age (≥60 years) (P = 0.043) and positive lymph node status (P = 0.027) were independently prognostic parameters for poorer DFS. Conclusions:Pre-operative serum ADA levels may serve as a reliable independent prognostic predictor for OS in OSCC patients. K E Y W O R D Soral and oropharynx, prognosis, serum adenosine deaminase, squamous cell carcinoma

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“…But corrupted liver functions can cause elevated bilirubin levels. 12 Therefore, patients with hepatobiliary disease were excluded from the study.…”

Section: Discussionmentioning

confidence: 99%

Is serum bilirubin level a predictor factor in parotid gland carcinoma?

Bulğurcu

İdil²,

Çukurova³

2020

Brazilian Journal of Otorhinolaryngology

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Serum bilirubin level predicts postoperative overall survival in oral squamous cell carcinoma

Abstract: Lower DBIL was associated with a poorer prognosis and may be regarded as an independent prognostic marker for patients with OSCC.

Cited by 7 publications

References 27 publications

Interplay Of Serum Bilirubin and Tobacco Smoking with Lung and Head and Neck Cancers in a Diverse, EHR-linked Los Angeles Biobank

Interplay Of Serum Bilirubin and Tobacco Smoking with Lung and Head and Neck Cancers in a Diverse, EHR-linked Los Angeles Biobank

Prognostic value of serum liver enzymes in oral and oropharynx squamous cell carcinomas

Is serum bilirubin level a predictor factor in parotid gland carcinoma?

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