Molecular evidence of offspring liver dysfunction after maternal exposure to zinc oxide nanoparticles

Hao, Yanan; Liu, Jing; Feng, Yanni; Yu, Shuai; Zhang, Weidong; Li, Lan; Liu, Min; Zhang, Hongfu; Shen, Wei; Zhao, Yong

doi:10.1016/j.taap.2017.06.021

Cited by 28 publications

(10 citation statements)

References 48 publications

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“…29 An additional hen animal study found that liver dysfunction identified in pregnant mothers was transferred to offspring. 31 Offspring of pregnant rats exposed to TiO 2 had increased apoptotic cells in the hippocampus and decreased overall neurogenesis. 30 A mouse model study demonstrated pre-mature ovarian failure from TiO 2 nanoparticles ingested via gavage.…”

Section: He Alth Con Cern Smentioning

confidence: 98%

“…Pregnant rats exposed to ZnO had decreased body and liver weight; however, no issues related to their pregnancy or offspring . An additional hen animal study found that liver dysfunction identified in pregnant mothers was transferred to offspring . Offspring of pregnant rats exposed to TiO 2 had increased apoptotic cells in the hippocampus and decreased overall neurogenesis .…”

Section: Health Concernsmentioning

confidence: 99%

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A review of inorganic UV filters zinc oxide and titanium dioxide

Schneider

Lim

2018

Photoderm Photoimm Photomed

217

124

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Summary Photoprotection has become integral in the prevention of keratinocyte cancer and photoaging. Organic ultraviolet (UV) filters such as oxybenzone and octinoxate have become controversial due to their potential impact on the environmental and their potential human health risks. As such, inorganic UV filters, zinc oxide (ZnO) and titanium dioxide (TiO2), have become paramount in discussions about photoprotection. ZnO and TiO2 are used in sunscreens as nanoparticles, which denotes a size <100 nm. The smaller size of these mineral particles increases their cosmetic acceptability by users as they are much less visible after application. ZnO has a broad UVA‐UVB absorption curve, while TiO2 provides better UVB protection. Overall, the human health risks with inorganic filters are extremely low given a lack of percutaneous absorption; however, there is potential risk when exposed via inhalation, prompting recommendations against spray sunscreen products with nanoparticles. At this time, the known risk to the environment is low though the risk stratification may evolve with increasing usage of these filters and higher environmental concentrations. The continued practice of photoprotection is critical. The public should be counseled to seek shade, use photoprotective clothing including hats and glasses in addition to sunscreens on sun‐exposed skin. For those concerned about emerging evidence of environmental impact of organic UV filters, based on current evidence, ZnO and TiO2‐containing sunscreens are safe alternatives.

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Section: He Alth Con Cern Smentioning

confidence: 98%

Section: Health Concernsmentioning

confidence: 99%

A review of inorganic UV filters zinc oxide and titanium dioxide

Schneider

Lim

2018

Photoderm Photoimm Photomed

217

124

View full text Add to dashboard Cite

show abstract

“…During the pregnancy stage, harmful effects of new products such as those containing ZnO NPs, affect the reproductive route inducing fetal malformation or even fetal death. Recently, some researches showed that ZnO NPs could cause reproductive and development toxicity, but insufficient studies had been devoted to determination of the internal mechanism involved in the reproductive toxicity of ZNOs [7,18,19].…”

Section: Discussionmentioning

confidence: 99%

Nano Zinc Oxide Induced Fetal Mice Growth Restriction, Based on Oxide Stress and Endoplasmic Reticulum Stress

et al. 2020

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ZnO NPs have been assessed to show adverse effects on reproductive organs, but the molecular mechanisms of reproductive toxicity have not been sufficiently studied. In this research, the dosage effects from the oral exposure of ZnO NPs (30 nm) to pregnant mice in gestation day 10.5 to 17.5 was analyzed. Pregnant mice exposed to ZnO NPs induced dam injury, mice fetal growth restriction, and the fetus number decreased. The pathological evaluation showed that ZnO NPs exposure caused placental spongiotrophoblast area decease and structural damage. The RT-qPCR and immunocytochemistry data indicated that ZnO NPs could induce placenta oxide stress, endoplasmic reticulum stress responses, apoptosis, and altered placental function. These findings indicated that ZnO NPs could induce dam injury and fetal growth restriction. Reproductive toxicity of ZnO NPs may be due to placental injury and function alteration caused by apoptosis, oxide stress, and endoplasmic reticulum stress after ZnO NPs exposure.

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“…ZnO NPs have been described as an easily accumulated nanomaterial, whose accumulation rate differs depending on the tissue type. Liver, kidney, lung, brain, and spleen are the organs with high ZnO NPs accumulation levels [63], presenting signals of cytotoxicity as a consequence of that exposure [64][65][66][67]. Besides that, metal nanoparticles have the capacity to cross the blood-testis barrier (BTB), in part by its size but also by the production of an inflammatory response that compromises the BTB integrity [62].…”

Section: Zno Nanoparticles: Route Of Exposure and Accumulation In Orgmentioning

confidence: 99%

The Impact of Zinc Oxide Nanoparticles on Male (In)Fertility

2020

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Zinc oxide nanoparticles (ZnO NPs) are among nanoscale materials, attracting increasing attention owing to their exceptional set of characteristics, which makes these engineered nanoparticles a great option for improving the quality and effectiveness of diagnosis and treatment. The capacity of ZnO NPs to induce reactive oxygen species (ROS) production, DNA damage, and apoptosis represents a promise for their use in both cancer therapy and microbial treatment. However, their intrinsic toxicity together with their easy entrance and accumulation in organism have raised some concerns regarding the biomedical use of these NPs. Several studies have reported that ZnO NPs might induce cytotoxic effects on the male reproductive system, compromising male fertility. Despite some advances in this area, the knowledge of the effects of ZnO NPs on male fertility is still scarce. Overall, a brief outline of the major ZnO NPs biomedical applications and promises in terms of diagnostic and therapeutic use will also be explored. Further, this review intends to discuss the effect of ZnO NPs exposure on the male reproductive system and speculate their effects on male (in)fertility.

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Molecular evidence of offspring liver dysfunction after maternal exposure to zinc oxide nanoparticles

Cited by 28 publications

References 48 publications

A review of inorganic UV filters zinc oxide and titanium dioxide

A review of inorganic UV filters zinc oxide and titanium dioxide

Nano Zinc Oxide Induced Fetal Mice Growth Restriction, Based on Oxide Stress and Endoplasmic Reticulum Stress

The Impact of Zinc Oxide Nanoparticles on Male (In)Fertility

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