Effect of heart failure reversal treatment as add-on therapy in patients with chronic heart failure: A randomized, open-label study

Sane, Rohit; Aklujkar, Abhijeet; Patil, Atul; Rahul, Morankar

doi:10.1016/j.ihj.2016.10.012

Cited by 11 publications

(12 citation statements)

References 24 publications

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“…The important outcome as per our study result is the sustained efficacy of HFRT post 90 days of therapy administration. HFRT has been reported earlier [4] to be helpful in CHF patients but results of this study report its effect post 90 days using NT-proBNP as a diagnostic marker.…”

Section: Discussionmentioning

confidence: 79%

“…A randomized control trial has shown HFRT to be efficacious and safe in CHF patients with 30-65% ejection fraction (EF). [4] Another HFRT study (article in press) confirmed its effect at 90 days follow-up in CHF patients with reduced EF.…”

Section: Introductionmentioning

confidence: 91%

“…HFRT is a therapeutic Ayurvedic treatment consisting of four major steps of Snehana, Sweden, Hrudaydhara, and Basti followed in the same order [4]. This procedure is performed twice in a day on patients with CHF for 7 consecutive days by trained and skilled staff.…”

Section: Study Therapymentioning

confidence: 99%

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To Evaluate the Efficacy of Heart Failure Reversal Therapy Using NT-Probnp Levels in Patients with Chronic Heart Failure

Rohit¹

2018

CCR

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Heart failure is considered as a life-threatening epidemic disorder affecting about 26 million world's population and associated with considerable morbidity, mortality and healthcare expenses. Despite the availability of a range of advanced treatments and sophisticated therapies the prevalence of heart failure represents a herculean challenge. To address the challenge, the current investigation was conducted by evaluating the efficacy of Heart Failure Reversal Therapy (HFRT) in reducing left ventricular distress by assessing N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in congestive heart failure (CHF) patients. Total 76 CHF patients with NYHA Class II and III were screened from March to May 2017 and 15 CHF patients with NT-proBNP = 300-1500 pg/ml were selected for the study. NT-proBNP is measured as a marker, the value of which increases with an increase in severity of CHF. The study therapy, HFRT comprises of traditional procedure of panchkarma that includes snehana (external oleation), swedana (passive heat therapy), hrudaydhara (concoction dripping treatment) and basti (medicated enema) was administered twice daily for 7 days. Post-HFRT, ARJ kadha was administered for next 12 weeks follow-up. NT-proBNP levels were measured after a follow-up period of 90 days along with some other parameters like BMI, VO 2peak (evaluated by cardiac stress test with modified Bruce protocol) and weight. The findings of the investigation revealed significant reduction in NT-proBNP levels (42.46%, p = 0.009), weight (4.82%, p = 0.0007) and BMI (3.67%, p = 0.034) at the end of the follow-up period. The study also yielded significant improvements in VO 2peak (50.96%, p = 0.004). The overall results suggest that HFRT can possibly be explored as add-on therapy or a feasible alternative for the effective management of CHF.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 91%

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To Evaluate the Efficacy of Heart Failure Reversal Therapy Using NT-Probnp Levels in Patients with Chronic Heart Failure

Rohit¹

2018

CCR

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“…Panchakarma is administered as add on therapy for IHD management, by Ayurveda physicians. 20 IRP is a 3 step procedure consisting of Snehana, Swedana, and Basti. Probable mode of action of IRP is Snehana-anxiolytic reduces sympathetic over activity Swedana-reduces sodium and fluid that reduces resting preload that may help to reduce myocardial oxygen demand.…”

Section: Discussionmentioning

confidence: 99%

“…This action may be helpful in improving coronary circulation by causing coronary vasodilation. 17,20,[22][23][24]26 In pursuit of analyzing the efficacy of the IRP in IHD, we found that it showed significant (very high statistical significance) improvement in VO2max, Duke's treadmill score, DBP, and SBP (high statistical significance) at the 90 th day of the whole procedure. SBP is one of the prognostic marker for patients of IHD.…”

Section: Discussionmentioning

confidence: 99%

Study of efficacy of ischemia reversal program (IRP) in ischemic heart disease (IHD) patients with VO2max and Duke’s treadmill score

Sane¹,

Sugwekar²,

Nadapude³

et al. 2018

Int J Basic Clin Pharmacol

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Background: Number of people dying from IHD has increased from 0.61 million in 1990 to 1.13 million in 2010, which is a disturbing fact. According to report by World Health Organization, India would be spending a whopping 237 billion US dollars, owing to direct spending on health care and indirectly due to loss of productivity due to IHD. Ischemia Reversal Program (IRP) is a combination of Panchakarma and allied therapy. This study was conducted to evaluate the effect of IRP on VO2max, Duke’s treadmill score, systolic blood pressure (SBP), diastolic blood pressure (DBP), and dependency on conventional therapy in IHD patients.Methods: This observational study was conducted in January 2017, wherein the data of IHD patients (inducible ischemia on stress testing) who attended out-patient departments (OPDs) at Madhavbaug clinics in Maharashtra, India were identified. Data of patients who were administered IRP (60-75 minutes) with minimum 7 sittings over 90 days (±15 days) were considered. Variables were compared between day 1 and day 90 of the IRP.Results: Out of 38 enrolled patients, 25 were males while 13 females. There was significant improvement in Duke’s score with subjects at moderate (50%) and high (31.6%) risk at baseline were significantly decreased to low (52.6%) and moderate (47.4%) after the 90th day of therapy. IRP also showed significant improvement in VO2max by 9.11 (from 20.29±6.72 to 29.40±6.71; p<0.001), SBP by 5.78 (from 128.78±17.40 to 123±12.23, p<0.03), DBP by 4.76 (from 80.53±8.10 to 75.76±6.85, p<0.005). Dependency on concomitant medicines was reduced.Conclusions: IRP was effective in IHD; it had dual benefits, i.e. anti-ischemic effect, as well as reducing the dependency on allopathic medicines.

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Managing monomorphic ventricular tachycardia without cardioversion: A case report

Kajaria¹,

Khobarkar²

2023

Journal of Ayurveda and Integrative Medicine

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Effect of heart failure reversal treatment as add-on therapy in patients with chronic heart failure: A randomized, open-label study

Abstract: Findings of this study highlight therapeutic efficacy of add-on HFRT vs. SCT-alone in CHF patients. The non-invasive HFRT showed no safety concerns.

Cited by 11 publications

References 24 publications

To Evaluate the Efficacy of Heart Failure Reversal Therapy Using NT-Probnp Levels in Patients with Chronic Heart Failure

To Evaluate the Efficacy of Heart Failure Reversal Therapy Using NT-Probnp Levels in Patients with Chronic Heart Failure

Study of efficacy of ischemia reversal program (IRP) in ischemic heart disease (IHD) patients with VO2max and Duke’s treadmill score

Managing monomorphic ventricular tachycardia without cardioversion: A case report

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