Antibacterial Effect of a 4x Cu-TiO2 Coating Simulating Acute Periprosthetic Infection—An Animal Model

Mauerer, Andreas; Stenglein, Stefanie; Schulz-Drost, Stefan; Schörner, Christoph; Taylor, Dominic; Krinner, Sebastian; Heidenau, Frank; Adler, Werner; Forst, Raimund

doi:10.3390/molecules22071042

Cited by 13 publications

(22 citation statements)

References 33 publications

(44 reference statements)

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“…Copper and copper-silver coatings were used by McLean, et al [ 97 ] to reduce bacterial activity in different catheter materials. Mauerer, et al [ 98 ] and Norambuena, et al [ 99 ] coated titanium alloy Ti6A14V with 4-fold copper-titanium oxide (CuTiO 2 ) and titanium-copper oxide (TiCuO), respectively, and evaluated their antibiofilm activity. Ti6A14V disc coated with a thin film of TiCuO with 80% copper content reduced S. epidermidis biofilm by 2.5 log of colony forming units (CFU).…”

Section: Copper Surfaces In Health Care Unitsmentioning

confidence: 99%

“…This material also demonstrated lower toxicity in normal human osteoblast [ 99 ]. Mauerer, et al [ 98 ] further investigated the antibacterial effect of the Ti6A14V spacer coated with 4×CuTiO 2 in an animal model, in order to simulate acute periprosthetic infection by S. aureus. The materials were implanted into the femoral condyle of rabbits and two weeks after the implementation of copper-titanium oxide coated spacers a decrease on the rabbits’ infection rate from 90% to 41.7% was observed [ 98 ].…”

Section: Copper Surfaces In Health Care Unitsmentioning

confidence: 99%

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Copper Surfaces in Biofilm Control

Gomes

Simões

2020

Nanomaterials

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Biofilms are structures comprising microorganisms associated to surfaces and enclosed by an extracellular polymeric matrix produced by the colonizer cells. These structures protect microorganisms from adverse environmental conditions. Biofilms are typically associated with several negative impacts for health and industries and no effective strategy for their complete control/eradication has been identified so far. The antimicrobial properties of copper are well recognized among the scientific community, which increased their interest for the use of these materials in different applications. In this review the use of different copper materials (copper, copper alloys, nanoparticles and copper-based coatings) in medical settings, industrial equipment and plumbing systems will be discussed considering their potential to prevent and control biofilm formation. Particular attention is given to the mode of action of copper materials. The putative impact of copper materials in the health and/or products quality is reviewed taking into account their main use and the possible effects on the spread of antimicrobial resistance.

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Section: Copper Surfaces In Health Care Unitsmentioning

confidence: 99%

Section: Copper Surfaces In Health Care Unitsmentioning

confidence: 99%

Copper Surfaces in Biofilm Control

Gomes

Simões

2020

Nanomaterials

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“…Infection prevention was achieved in animal models in which titanium implants were coated with copper 15 , copper-titanium dioxide 16 , and magnesium 17 . Infection prevention was also achieved by administering active and passive immunization against Staphylococcus aureus in a rat model 18 .…”

Section: Preventionmentioning

confidence: 99%

What’s New in Musculoskeletal Infection

McLaren

Nana²,

Chen

et al. 2018

The Journal of Bone and Joint Surgery

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This Update on musculoskeletal infection presents a review of infection-related articles from 2017, from journals in the National Center for Biotechnology Information (NCBI) databases in the clinical areas of arthroplasty, orthopaedic oncology, orthopaedic trauma, pediatric orthopaedics, and hand surgery. Publications on infectious-disease topics that were relevant to orthopaedics, including antimicrobial prophylaxis (locally applied vancomycin powder), and the Centers for Disease Control and Prevention (CDC) guidelines on surgical site infection (SSI) prevention, published in 2017, were also reviewed. Methods Articles for review were selected by searching all journals in the NCBI databases for the infection-related terms "orthop(a)edic infection," "osteomyelitis," "bone infection," "implant infection," "fracture infection," "septic arthritis," and "biofilm" in combination with terms pertaining to clinical areas of interest: "arthroplasty," "orthop(a)edic oncology," "orthop(a)edic trauma," "fracture," "open fracture," "wound closure," "hand," "finger," "wrist," "child," "children," and "p(a)ediatric(s)." We also searched for "vancomycin powder," "local vancomycin," "intra-wound vancomycin," "intra-operative vancomycin," "intra-site vancomycin," and "topical vancomycin" in all NCBI database journals without associated clinical areaof-interest search terms. Reviewed were English-language papers that were published in 2017 and that reported infection as the topic of focus, the purpose of investigation, or the critical finding, as identified on a review of the title and abstract; we excluded papers that had infection as an incidental finding or were expert opinion. We used our editorial discretion to identify articles that are pertinent and relevant to the readership. A total of 378 articles were identified; 137 are reviewed. The vast majority of the studies were case reports and retrospective reviews, often without controls, that add observations and author experience to our knowledge base but do not provide strong evidence to direct practice. There were few prospective controlled trials or high-quality, large database studies with scientifically valid findings. Antimicrobial Prophylaxis Locally Applied Vancomycin Powder Recent retrospective series have demonstrated associations between the use of vancomycin powder prior to wound closure in spine surgery and reductions in SSI risk; prospective randomized controlled studies are still ongoing. The apparent success of topical vancomycin powder in preventing infection in spine surgery has raised the possibility of its benefit in other surgical fields, including those outside of orthopaedics. Additional studies have focused on the side-effects and impact of vancomycin powder use on the microbial etiology of infection. In the spine literature, 2 retrospective studies noted associations between vancomycin powder use and lower infection risk among surgical patients 1,2. With respect to other orthopaedic disciplines, the use of vancomycin powder was associated with a lower o...

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Section: Preventionmentioning

confidence: 99%