Copper Surfaces in Biofilm Control

Gomes, Inês B.; Simões, Manuel; Simões, Lúcia C.

doi:10.3390/nano10122491

Cited by 35 publications

(19 citation statements)

References 138 publications

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“…In fact, biofilms play an important role in the development of bacterial resistance against antibiotics and other antibacterial agents [63]. Numerous studies have shown that metal-based NPs, including AuNPs [64], AgNPs [65], MgONPs [66], ZnONPs [67], and CuONPs [68], can prevent or overcome biofilm formation.…”

Section: Metal-based Nanoparticles Target Ros Production In Bacteriamentioning

confidence: 99%

Current Knowledge on the Oxidative-Stress-Mediated Antimicrobial Properties of Metal-Based Nanoparticles

et al. 2022

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The emergence of multidrug-resistant (MDR) bacteria in recent years has been alarming and represents a major public health problem. The development of effective antimicrobial agents remains a key challenge. Nanotechnologies have provided opportunities for the use of nanomaterials as components in the development of antibacterial agents. Indeed, metal-based nanoparticles (NPs) show an effective role in targeting and killing bacteria via different mechanisms, such as attraction to the bacterial surface, destabilization of the bacterial cell wall and membrane, and the induction of a toxic mechanism mediated by a burst of oxidative stress (e.g., the production of reactive oxygen species (ROS)). Considering the lack of new antimicrobial drugs with novel mechanisms of action, the induction of oxidative stress represents a valuable and powerful antimicrobial strategy to fight MDR bacteria. Consequently, it is of particular interest to determine and precisely characterize whether NPs are able to induce oxidative stress in such bacteria. This highlights the particular interest that NPs represent for the development of future antibacterial drugs. Therefore, this review aims to provide an update on the latest advances in research focusing on the study and characterization of the induction of oxidative-stress-mediated antimicrobial mechanisms by metal-based NPs.

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Section: Metal-based Nanoparticles Target Ros Production In Bacteriamentioning

confidence: 99%

Current Knowledge on the Oxidative-Stress-Mediated Antimicrobial Properties of Metal-Based Nanoparticles

et al. 2022

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“…Copper, along with silver, belongs to the most widespread class of antimicrobial surfaces, in the case of which the antibacterial active agent is constantly released from the coatings [13]. One of the drawbacks of such surfaces is the accumulation of dead bacterial mass on the surfaces and, thus, the blocking of the active and metal-ion-releasing surface [14]. This issue could be resolved by the use of reactive in-situacting photocatalytic surfaces.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Photocatalytically Active Antibacterial Surfaces Covered with Acrylic Matrix Embedded Nano-ZnO and Nano-ZnO/Ag

et al. 2021

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In the context of healthcare-acquired infections, microbial cross-contamination and the spread of antibiotic resistance, additional passive measures to prevent pathogen carryover are urgently needed. Antimicrobial high-touch surfaces that kill microbes on contact or prevent their adhesion could be considered to mitigate the spread. Here, we demonstrate that photocatalytic nano-ZnO- and nano-ZnO/Ag-based antibacterial surfaces with efficacy of at least a 2.7-log reduction in Escherichia coli and Staphylococcus aureus viability in 2 h can be produced by simple measures using a commercial acrylic topcoat for wood surfaces. We characterize the surfaces taking into account cyclic wear and variable environmental conditions. The light-induced antibacterial and photocatalytic activities of the surfaces are enhanced by short-term cyclic wear, indicating their potential for prolonged effectivity in long-term use. As the produced surfaces are generally more effective at higher relative air humidity and silver-containing surfaces lost their contact-killing properties in dry conditions, it is important to critically evaluate the end-use conditions of materials and surfaces to be tested and select application-appropriate methods for their efficacy assessment.

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“…As indicated by the SEM images in Figure , the treatment of P. syringae (as an example) with the SLC Cu-BTC MOFs led to abnormal blebbing of the bacterial cell membrane, indicating weakening of the cell membrane. − This further suggests that the interaction of the bacterial cells with the Cu 2+ ions on the surface of the SLC Cu-BTC MOFs resulted in cell membrane destabilization, therefore making them more vulnerable to subsequent lysis by physical forces. Such an assertion is also consistent with the observation of the normal morphology of bacterial cells that were treated with the cubic Cu-BTC MOFs.…”

Section: Discussionmentioning

confidence: 94%

Enhanced Antimicrobial Activity and Low Phytotoxicity of Acoustically Synthesized Large Aspect Ratio Cu-BTC Metal–Organic Frameworks with Exposed Metal Sites

Marqus

Ahmed

Rezk

et al. 2021

ACS Appl. Mater. Interfaces

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Metal−organic frameworks (MOFs) have recently been shown to be effective antimicrobial agents, particularly if they comprise pathogenicidal metal ions. Nevertheless, the accessibility of these active metal sites to the pathogen, and hence the MOFs' antimicrobial activity itself, is often poor since the metal nodes are usually embedded deep within its three-dimensional (3D) structure. We show that a unique copper-based (copper(II)-benzene-1,3,5-tricarboxylate) MOF, whose quasi-two-dimensional (quasi-2D) swordlike structure facilitates exposure of the metal ions along its surface, exhibits enhanced antimicrobial properties against three representative plant pathogens: a bacterium (Pseudomonas syringae), a fungus (Fusarium solani), and a virus (Odontoglossum ringspot virus (ORSV)). Such superior antimicrobial activity results in low minimum inhibitory concentrations (MICs)half that of a commercial pesticide and an eighth of its conventional 3D cubic MOF counterpart (HKUST-1)and hence low phytotoxicity, which can be attributed to the accessibility of the surface copper sites to the pathogen, thereby facilitating their adhesion and physical contact with the MOF. Additionally, we observed that orchids treated with the quasi-2D MOF showed negligible phytotoxicity and 80% decreased viral load. This work constitutes the first study to demonstrate the antimicrobial properties of this novel MOF against bacterial, fungal, and viral plant pathogens, and the first chemical control of ORSV.

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Copper Surfaces in Biofilm Control

Cited by 35 publications

References 138 publications

Current Knowledge on the Oxidative-Stress-Mediated Antimicrobial Properties of Metal-Based Nanoparticles

Current Knowledge on the Oxidative-Stress-Mediated Antimicrobial Properties of Metal-Based Nanoparticles

Preparation and Characterization of Photocatalytically Active Antibacterial Surfaces Covered with Acrylic Matrix Embedded Nano-ZnO and Nano-ZnO/Ag

Enhanced Antimicrobial Activity and Low Phytotoxicity of Acoustically Synthesized Large Aspect Ratio Cu-BTC Metal–Organic Frameworks with Exposed Metal Sites

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