Oxytocin und die suchterhaltenden Mechanismen der Alkoholabhängigkeit

Faehrmann, Till; Zernig, Gerald; Mechtcheriakov, Sergei

doi:10.1007/s40211-017-0229-y

Cited by 4 publications

(5 citation statements)

References 55 publications

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“…2018; 11(10):e81752. In this regard and in line with the primary outcome of the present study, the results of the study conducted by Faehrmann et al (2) show that oxytocin by reducing the anxiety and depression, can reduce the mechanism of craving in alcohol dependent people and help the patient in the abstinent phase.…”

Section: Discussionsupporting

confidence: 88%

“…In accordance with our findings, the results of study performed by Love et al (4) show that oxytocin, by increasing social participation and improving mental health, improves psychological indices such as depression in alcohol users. The findings of a study conducted by Faehrmann et al (2) suggest the moderator role of oxytocin on stress-related pathways in alcohol dependent individuals, which can be used in treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Along with conventional treatments for cancer, alcohol use control can increase survival rates in these patients. In the first months of absenteeism, alcoholdependent patients often show sleep disorders, irritability, and depression, which indicate chronic activity of the stress-related pathways (2). In addition, losing selfconfidence in interpersonal interactions leads to social deprivation and reduced willingness to participate in therapeutic programs.…”

Section: Introductionmentioning

confidence: 99%

“…From the neurobiological point of view, it has been suggested that the oxytocin social hormone can be effective on addictive behaviors such as alcohol use through the promotion of social interactions and the improvement of psychological indices (4). Oxytocin acts by inhibiting the effects of corticotropin-releasing hormone (CRH) on GABAergic interneuron in amygdala and hypothalamic nuclei (2). Studies have shown that heavy alcohol consumption is associated with lower levels of oxytocin in the brain, and this process is referred to as a mechanism for changes in social behavior, response to stress, and increasing alcohol abuse (5).…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Oxytocin on Reducing Alcohol Consumption and Depression Syndrome in a Patient with Oropharyngeal Carcinoma

Pirnia

Pirnia²

2018

Int J Cancer Manag

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Introduction: Stopping or controlling alcohol consumption in alcohol-related cancers can increase survival rates. Oxytocin due to its potential in craving modulation has been suggested as an alternative therapy. Case Presentation: The patient was alcohol-abused 67-year-old male with a diagnosis of metastatic oropharyngeal squamous cell carcinoma and dysthymia syndrome, which was selected using a respondent-driven sampling (RDS) method. The patient was treated with intranasal oxytocin in two stages and for 6 weeks, and in the control phase, placebo was used. Alcohol consumption rate, its related problems, and changes in the depression index were considered as the primary outcome. The association of mood with alcohol consumption was considered as the secondary outcome. The data were analyzed, using the generalized estimation equation (GEE), a generalized linear mixed models (random effect model) with repeated measures, and repeated measures correlation. Primary outcomes showed that intranasal oxytocin caused a significant decrease in alcohol consumption and its problems related to mood. However, this reduction did not remain until the follow-up stage. Secondary outcomes showed that there is a direct relationship between the dysthymia index and alcohol consumption. Conclusions: The reduction of neurotic cue reactivity induced by the oxytocin function can, with the improvement of the mood, stop the cycle of craving and consumption. However, this hypothesis requires controlled clinical trials.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effectiveness of Oxytocin on Reducing Alcohol Consumption and Depression Syndrome in a Patient with Oropharyngeal Carcinoma

Pirnia

Pirnia²

2018

Int J Cancer Manag

View full text Add to dashboard Cite

show abstract

“…Furthermore, intracerebroventricular application of OT completely blocked alcohol-induced dopamine release within the nucleus accumbens (Peters et al, 2017) that is a well-known nucleus of rewarding. Mechanistically, OT was considered to act by inhibiting the effects of the corticotropin-releasing factor on GABAergic interneurons in the amygdala and PVN, which suppressed the mechanisms of relapse and craving by reducing anxiety, stress vulnerability, and social withdrawal in abstinent alcohol-dependent patients (Faehrmann et al, 2018). By improving these life-styles, OT may also help to suppress the development of atherosclerotic CVD.…”

Section: Mechanisms Underlying the Protective Effects Of Otmentioning

confidence: 99%

Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways

Wang

Yang

et al. 2019

Front. Neurosci.

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Coronary artery disease (CAD) is a major cardiovascular disease responsible for high morbidity and mortality worldwide. The major pathophysiological basis of CAD is atherosclerosis in association with varieties of immunometabolic disorders that can suppress oxytocin (OT) receptor (OTR) signaling in the cardiovascular system (CVS). By contrast, OT not only maintains cardiovascular integrity but also has the potential to suppress and even reverse atherosclerotic alterations and CAD. These protective effects of OT are associated with its protection of the heart and blood vessels from immunometabolic injuries and the resultant inflammation and apoptosis through both peripheral and central approaches. As a result, OT can decelerate the progression of atherosclerosis and facilitate the recovery of CVS from these injuries. At the cellular level, the protective effect of OT on CVS involves a broad array of OTR signaling events. These signals mainly belong to the reperfusion injury salvage kinase pathway that is composed of phosphatidylinositol 3-kinase-Akt-endothelial nitric oxide synthase cascades and extracellular signal-regulated protein kinase 1/2. Additionally, AMP-activated protein kinase, Ca 2+ /calmodulin-dependent protein kinase signaling and many others are also implicated in OTR signaling in the CVS protection. These signaling events interact coordinately at many levels to suppress the production of inflammatory cytokines and the activation of apoptotic pathways. A particular target of these signaling events is endoplasmic reticulum (ER) stress and mitochondrial oxidative stress that interact through mitochondria-associated ER membrane. In contrast to these protective effects and machineries, rare but serious cardiovascular disturbances were also reported in labor induction and animal studies including hypotension, reflexive tachycardia, coronary spasm or thrombosis and allergy. Here, we review our current understanding of the protective effect of OT against varieties of atherosclerotic etiologies as well as the approaches and underlying mechanisms of these effects. Moreover, potential cardiovascular disturbances following OT application are also discussed to avoid unwanted effects in clinical trials of OT usages.

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The association of oxytocin with major depressive disorder: role of confounding effects of antidepressants

Xie

Fang

et al. 2021

Reviews in the Neurosciences

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Major depressive disorder is a genetic susceptible disease, and a psychiatric syndrome with a high rate of incidence and recurrence. Because of its complexity concerning etiology and pathogenesis, the cure rate of first-line antidepressants is low. In recent years, accumulative evidences revealed that oxytocin act as a physiological or pathological participant in a variety of complex neuropsychological activities, including major depressive disorder. Six electronic databases (Web of Science, PubMed, Scopus, Google Scholar, CNKI, and Wanfang) were employed for researching relevant publications. At last, 226 articles were extracted. The current review addresses the correlation of the oxytocin system and major depressive disorder. Besides, we summarize the mechanisms by which the oxytocin system exerts potential antidepressant effects, including regulating neuronal activity, influencing neuroplasticity and regeneration, altering neurotransmitter release, down regulating hypothalamic–pituitary–adrenal axis, anti-inflammatory, antioxidation, and genetic effects. Increasing evidence shows that oxytocin and its receptor gene may play a potential role in major depressive disorder. Future research should focus on the predictive ability of the oxytocin system as a biomarker, as well as its role in targeted prevention and early intervention of major depressive disorder.

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Oxytocin und die suchterhaltenden Mechanismen der Alkoholabhängigkeit

Cited by 4 publications

References 55 publications

Effectiveness of Oxytocin on Reducing Alcohol Consumption and Depression Syndrome in a Patient with Oropharyngeal Carcinoma

Effectiveness of Oxytocin on Reducing Alcohol Consumption and Depression Syndrome in a Patient with Oropharyngeal Carcinoma

Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways

The association of oxytocin with major depressive disorder: role of confounding effects of antidepressants

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