Effects of salt loading and potassium supplement on the circadian blood pressure profile in salt-sensitive Chinese patients

Guo, Tongshuai; Dai, Yi; Ren, Keyu; Mu, Jianjun; Ren, Jie; Wang, Dan; Wang, Yan; Chu, Chao; Li, Yan; Yuan, Zuyi

doi:10.1097/mbp.0000000000000276

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…High sodium diet caused non-dipping blood pressure in nearly half of the participants but was reversed to dipper status after potassium intervention. Similar results were achieved in salt-sensitive subjects in China (95). In CKD patients, Agarwal showed that urinary excretion of potassium was significantly higher at night compared with daytime (96), whereas the majority of potassium is normally excreted during daytime in healthy individuals (97).…”

Section: Potassium Homeostasis and Circadian Rhythmssupporting

confidence: 61%

Diurnal Regulation of Renal Electrolyte Excretion: The Role of Paracrine Factors

Zhang

Pollock

2020

Annu. Rev. Physiol.

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Many physiological processes, including most kidney-related functions, follow specific rhythms tied to a 24-h cycle. This is largely because circadian genes operate in virtually every cell type in the body. In addition, many noncanonical genes have intrinsic circadian rhythms, especially within the liver and kidney. This new level of complexity applies to the control of renal electrolyte excretion. Furthermore, there is growing evidence that paracrine and autocrine factors, especially the endothelin system, are regulated by clock genes. We have known for decades that excretion of electrolytes is dependent on time of day, which could play an important role in fluid volume balance and blood pressure control. Here, we review what is known about the interplay between paracrine and circadian control of electrolyte excretion. The hope is that recognition of paracrine and circadian factors can be considered more deeply in the future when integrating with well-established neuroendocrine control of excretion.

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Section: Potassium Homeostasis and Circadian Rhythmssupporting

confidence: 61%

Diurnal Regulation of Renal Electrolyte Excretion: The Role of Paracrine Factors

Zhang

Pollock

2020

Annu. Rev. Physiol.

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“…The reduction in urinary sodium excretion rate was positively correlated with the degree of BP reduction, especially in hypertensive patients, elderly people, and nonwhite population 56 . A study from China revealed potassium supplementation (4.5 g potassium chloride/d) can significantly improve the insufficient decrease of nighttime BP caused by excessive sodium intake (18 g salt/d) in salt‐sensitive people 57 . Currently, the World Health Organization (WHO) and relevant hypertension guidelines recommend daily salt intake less than 5 g in adults, 58 with appropriate consumption of potassium‐rich foods (such as fresh fruits, vegetables and beans), and those with normal renal function can choose potassium‐enriched substitutes 53,59 …”

Section: Treatmentmentioning

confidence: 99%

Management of nocturnal hypertension: An expert consensus document from Chinese Hypertension League

Liu,

Li,

Zhang

et al. 2023

J of Clinical Hypertension

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Nocturnal hypertension is highly prevalent among Chinese and Asian populations, which is mainly attributed to high salt intake and high salt sensitivity. Nocturnal hypertension increases the risk of cardiovascular and all‐cause mortality, independent of daytime blood pressure (BP). However, it can usually be detected by 24‐h ambulatory BP monitoring, rather than routine office or home BP measurement, thus is often underdiagnosed in clinical practice. Currently, no specific guidance is available for the management of nocturnal hypertension in China or worldwide. Experts from the Chinese Hypertension League summarized the epidemiologic and pathophysiologic characteristics and clinical phenotype of nocturnal hypertension and provided consensus recommendations on optimal management of nocturnal hypertension, with the goal of maximally reducing the cardiovascular disease risks. In this consensus document, 24‐h ABPM is recommended for screening and diagnosis of nocturnal hypertension, especially in the elderly, patients with diabetes, chronic kidney diseases, obstructive sleep apnea and other conditions prone to high nocturnal BP. Lifestyle modifications including salt intake restriction, exercise, weight loss, sleep improvement, and mental stress relief are recommended. Long‐acting antihypertensive medications are preferred for nocturnal and 24‐h BP control. Some newly developed agents, renal denervation, and other device‐based therapy on nocturnal BP reduction are evaluated.

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Prophylaxe und Therapie der diabetischen Nephropathie

Kettner

Mann²

2017

Nephrologe

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Effects of salt loading and potassium supplement on the circadian blood pressure profile in salt-sensitive Chinese patients

Abstract: Potassium supplement can improve the blunted nocturnal blood pressure fall in SS patients exposed to a high-salt diet, but the related mechanism needs to be studied further.

Cited by 5 publications

References 29 publications

Diurnal Regulation of Renal Electrolyte Excretion: The Role of Paracrine Factors

Diurnal Regulation of Renal Electrolyte Excretion: The Role of Paracrine Factors

Management of nocturnal hypertension: An expert consensus document from Chinese Hypertension League

Prophylaxe und Therapie der diabetischen Nephropathie

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