Diurnal Regulation of Renal Electrolyte Excretion: The Role of Paracrine Factors

Zhang, Dingguo; Pollock, David M.

doi:10.1146/annurev-physiol-021119-034446

Cited by 21 publications

(12 citation statements)

References 126 publications

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“…Emerging evidence continues to indicate the importance of circadian control of sodium homeostasis and BP. 14,[28][29][30] The current studies further demonstrate that the impairment of the aldosterone and ET-1 systems are more evident during the active period, a time when there is more food and water intake, and therefore, a time when precise control of sodium and water control by the kidney is more active.…”

Section: Discussionsupporting

confidence: 60%

Sex Differences in Diurnal Sodium Handling During Diet-Induced Obesity in Rats

et al. 2022

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Background: Emerging evidence over the past several years suggests that diurnal control of sodium excretion is sex dependent and involves the renal endothelin system. Given recent awareness of disruptions of circadian function in obesity, we determined whether diet-induced obesity impairs renal handling of an acute salt load at different times of day and whether this varies by sex and is associated with renal endothelin dysfunction. Methods: Male and female Sprague-Dawley rats were placed on a high-fat diet for 8 weeks before assessing renal sodium handling and blood pressure. Results: Male, but not female, rats on high fat had a significantly reduced natriuretic response to acute NaCl injection at the beginning of their active period that was associated with lower endothelin 1 (ET-1) excretion, lower ET-1 mRNA expression in the cortex and outer medulla as well as lower ET B receptor expression in the outer medulla of the high-fat rats. Obese males also had significantly higher blood pressure (telemetry) that was exacerbated by adding high salt to the diet during the last 2 weeks. While female rats developed hypertension with a high-fat diet, they were not salt sensitive and ET-1 excretion was unchanged. Conclusions: These data identify diet-induced obesity as a sex-specific disruptive factor for maintaining proper sodium handling. Although high-fat diets induce hypertension in both sexes, these data reveal that males are at greater risk of salt-dependent hypertension and further suggest that females have more redundant systems that can be productive against salt-sensitive hypertension in at least some circumstances.

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Section: Discussionsupporting

confidence: 60%

Sex Differences in Diurnal Sodium Handling During Diet-Induced Obesity in Rats

et al. 2022

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“…Use of BMAL1 knockout (KO) mouse models provides a way to gain a better understanding of the mechanism behind these human findings. Data from several mouse models have already demonstrated a link between BMAL1 and blood pressure, as summarized below and in recent review articles (45). Curtis et al (5) demonstrated that male global BMAL1 KO mice have ~10 mmHg lower blood pressure than wild-type mice.…”

Section: Introductionmentioning

confidence: 95%

Differences in renal BMAL1 contribution to Na⁺homeostasis and blood pressure control in male and female mice

Crislip

Douma

Masten

et al. 2020

American Journal of Physiology-Renal Physiology

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The renal circadian clock has a major influence on the function of the kidney. Aryl hydrocarbon receptor nuclear translocator-like protein 1 [ARNTL; also known as brain and muscle ARNT-like 1 (BMAL1)] is a core clock protein and transcription factor that regulates the expression of nearly half of all genes. Using male and female kidney-specific cadherin BMAL1 knockout (KS-BMAL1 KO) mice, we examined the role of renal distal segment BMAL1 in blood pressure control and solute handling. We confirmed that this mouse model does not express BMAL1 in thick ascending limb, distal convoluted tubule, and collecting duct cells, which are the final locations for solute and fluid regulation. Male KS-BMAL1 KO mice displayed a substantially lower basal systolic blood pressure compared with littermate control mice, yet their circadian rhythm in pressure remained unchanged [male control mice: 127 ± 0.7 mmHg ( n = 4) vs. male KS-BMAL KO mice: 119 ± 2.3 mmHg ( n = 5), P < 0.05]. Female mice, however, did not display a genotype difference in basal systolic blood pressure [female control mice: 120 ± 1.6 mmHg ( n = 5) vs. female KS-BMAL1 KO mice: 119 ± 1.5 mmHg ( n = 7), P = 0.4]. In addition, male KS-BMAL1 KO mice had less Na+ retention compared with control mice in response to a K+-restricted diet (15% less following 5 days of treatment). However, there was no genotype difference in Na+ handling after a K+-restricted diet in female mice. Furthermore, there was evidence indicating a sex-specific response to K+ restriction where female mice reabsorbed less Na+ in response to this dietary challenge compared with male mice. We propose that BMAL1 in the distal nephron and collecting duct contributes to blood pressure regulation and Na+ handling in a sex-specific manner.

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“…The central circadian clock lies in the suprachiasmatic nucleus in the anterior hypothalamus and coordinates peripheral clocks, including the kidney circadian clock which, in turn, coordinate local physiologic functions with patterns of activity and/or feeding [17]. Several signals contribute to coordinate peripheral circadian rhythms, including hormone secretion (e.g., production of the melatonin hormone by the pineal gland during nighttime, circadian production of aldosterone), neuronal activity (including physical activity and feeding) and body temperature.…”

Section: Biological Rhythmsmentioning

confidence: 99%

Chronodisruption: A Poorly Recognized Feature of CKD

Carriazo

Ramos

Sanz

et al. 2020

Toxins

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Multiple physiological variables change over time in a predictable and repetitive manner, guided by molecular clocks that respond to external and internal clues and are coordinated by a central clock. The kidney is the site of one of the most active peripheral clocks. Biological rhythms, of which the best known are circadian rhythms, are required for normal physiology of the kidneys and other organs. Chronodisruption refers to the chronic disruption of circadian rhythms leading to disease. While there is evidence that circadian rhythms may be altered in kidney disease and that altered circadian rhythms may accelerate chronic kidney disease (CKD) progression, there is no comprehensive review on chronodisruption and chronodisruptors in CKD and its manifestations. Indeed, the term chronodisruption has been rarely applied to CKD despite chronodisruptors being potential therapeutic targets in CKD patients. We now discuss evidence for chronodisruption in CKD and the impact of chronodisruption on CKD manifestations, identify potential chronodisruptors, some of them uremic toxins, and their therapeutic implications, and discuss current unanswered questions on this topic.

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Diurnal Regulation of Renal Electrolyte Excretion: The Role of Paracrine Factors

Cited by 21 publications

References 126 publications

Sex Differences in Diurnal Sodium Handling During Diet-Induced Obesity in Rats

Sex Differences in Diurnal Sodium Handling During Diet-Induced Obesity in Rats

Differences in renal BMAL1 contribution to Na⁺homeostasis and blood pressure control in male and female mice

Chronodisruption: A Poorly Recognized Feature of CKD

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Diurnal Regulation of Renal Electrolyte Excretion: The Role of Paracrine Factors

Cited by 21 publications

References 126 publications

Sex Differences in Diurnal Sodium Handling During Diet-Induced Obesity in Rats

Sex Differences in Diurnal Sodium Handling During Diet-Induced Obesity in Rats

Differences in renal BMAL1 contribution to Na+homeostasis and blood pressure control in male and female mice

Chronodisruption: A Poorly Recognized Feature of CKD

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Product

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Differences in renal BMAL1 contribution to Na⁺homeostasis and blood pressure control in male and female mice