Xanthophyll esters are found in human colostrum

Ríos, José Julián; Xavier, Ana Augusta Odorissi; Díaz-Salido, Elena; Arenilla-Vélez, Isabel; Jarén‐Galán, Manuel; Garrido‐Fernández, Juan; Aguayo-Maldonado, Josefa; Pérez‐Gálvez, Antonio

doi:10.1002/mnfr.201700296

Cited by 30 publications

(25 citation statements)

References 49 publications

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“…Carotenoids are considered to be normally present only in their free forms in human plasma. Although the accumulation of carotenoid esters has previously been reported in human skin, and most recently in human colostral milk, small amounts of carotenoid esters that might have been briefly present in human plasma TRL fractions . It has been hypothesized that the cleavage step takes place in the intestinal phase of digestion.…”

Section: Factors Affecting Carotenoid Bioaccessibilitymentioning

confidence: 99%

Bioaccessibility of carotenoids from plant and animal foods

2019

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The frequent consumption of carotenoid‐rich foods has been associated with numerous health benefits, such as the supply of provitamin A. To exert these health benefits, carotenoids need to be efficiently liberated from the food matrix, micellized in the small intestine, taken up by the enterocytes and absorbed into the human blood stream. Enormous efforts have been made to better understand these processes. Because human studies are costly, labor‐intense and time‐consuming, the evaluation of carotenoid liberation and micellization at the laboratory scale using simulated in vitro digestion models has proven to be an important tool for obtaining preliminary results prior to conducting human studies. In particular, the liberation from the food matrix and the intestinal micellization can be mimicked by simulated digestion, yielding an estimate of the so‐called bioaccessibility of a carotenoid. In the present review, we provide an overview of the carotenoid digestion process in vivo, the currently used in vitro digestion models and the outcomes of previous bioaccessibility studies, with a special focus on correlations with concomitantly conducted human studies. Furthermore, we advocate for the on‐going requirement of better standardized digestion protocols and, in addition, we provide suggestions for the complementation of the acquired knowledge and current nutritional recommendations. © 2018 Society of Chemical Industry

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Section: Factors Affecting Carotenoid Bioaccessibilitymentioning

confidence: 99%

Bioaccessibility of carotenoids from plant and animal foods

2019

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“…Carotenoids are universally present components in the human diet and are known to be present in colostrum and mature milk from mothers . The U.S. Food and Drug Administration has repeatedly accepted the Generally Recognized As Safe declarations made by supplement manufacturers for several carotenoid‐rich products, including palm oil carotenoids, several lutein‐containing, zeaxanthin‐containing, and lycopene‐containing products, some of them tomato‐based and also contain the colorless carotenoids phytoene and phytofluene…”

Section: Importance Of Carotenoids In Agro‐food Health and Diseasementioning

confidence: 99%

“…Safety of Carotenoids: Carotenoids are universally present components in the human diet and are known to be present in colostrum and mature milk from mothers. [108][109][110][111] The U.S. Food and Drug Administration has repeatedly accepted the Generally Recognized As Safe declarations made by supplement manufacturers for several carotenoid-rich products, including palm oil carotenoids, [112] several lutein-containing, [113][114][115][116][117][118] zeaxanthin-containing, [119][120][121] and lycopene-containing products, some of them tomato-based and also contain the colorless carotenoids phytoene and phytofluene. [122][123][124][125] Notably, dietary carotenoids are safe at concentrations much higher than those that are usually achievable in humans conforming to normal dietary patterns.…”

Section: Safety and Toxicity Of Carotenoids And Their Derivativesmentioning

confidence: 99%

An Overview of Carotenoids, Apocarotenoids, and Vitamin A in Agro‐Food, Nutrition, Health, and Disease

Meléndez-Martínez

2019

Molecular Nutrition Food Res

178

126

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Carotenoids are fascinating compounds that can be converted into many others, including retinoids that also play key roles in many processes. Although carotenoids are largely known in the context of food science, nutrition, and health as natural colorants and precursors of vitamin A (VA), evidence has accumulated that even those that cannot be converted to VA may be involved in health‐promoting biological actions. It is not surprising that carotenoids (most notably lutein) are among the bioactives for which the need to establish recommended dietary intakes have been recently discussed. In this review, the importance of carotenoids (including apocarotenoids) and key derivatives (retinoids with VA activity) in agro‐food with relevance to health is summarized. Furthermore, the European Network to Advance Carotenoid Research and Applications in Agro‐Food and Health (EUROCAROTEN) is introduced. EUROCAROTEN originated from the Ibero‐American Network for the Study of Carotenoids as Functional Food Ingredients (IBERCAROT).

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“…Therefore, the extraction methods mean the application of similar protocols applied for the extraction of free carotenoids, but the oily-dense nature of some matrices containing carotenoid esters requires clean-up steps. Different approaches have been set up, including the utilization of open column chromatography on silica gel [17] or magnesium oxide [18], enzymatic hydrolysis [19], solid-phase extraction [20], or even the use of semi-preparative isolation on C18 column and subsequent identification [21].…”

Section: Extraction Of Carotenoids and Sample Preparation For Analysismentioning

confidence: 99%

“…Another significant improvement in the hardware configuration of the mass spectrometer is the incorporation of a second stage of m/z analysis to obtain the mass spectra of selected ions. Thus, the arrangement of mass spectrometers in a tandem configuration to structure hybrid mass spectrometers (Q-time-of-flight, Q-IT, and triple Q-Orbitrap) [2,20,64,[83][84][85][86][87] allows the achievement of higher performance by increasing the mass accuracy level and the record of mass spectrum of a precursor ion to generate product ions. This configuration is essential when soft ionization methods are applied because they barely produce fragment ions and the experimental information from the MS analysis would limit to m/z values and isotopic pattern.…”

Section: Mass Spectrometersmentioning

confidence: 99%

Recent Developments in the Analysis of Carotenoids by Mass Spectrometry

Pérez‐Gálvez¹,

Roca²

2018

Progress in Carotenoid Research

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Mass spectrometry has become an indispensable tool for the analysis of carotenoids in photosynthetic tissues, foods, and biological materials from different sources to accurately establish their pigment profile, to provide evidences to distinguish the different structural arrangements, and to obtain biological meaning from metabolic processes where carotenoids participate during the development of their natural functions and activities. The recent progresses in the hyphenated HPLC systems with hybrid mass spectrometers, which enhance the acquisition of independent and complementary physicochemical properties for the identification of carotenoids, are detailed in this chapter. A reasonable guide for the implementation of post-processing routines, assisted by modern software tools, and the key issues for the analysis of the characteristic product ions are also defined in this contribution to help the readers in the understanding of the potential capabilities of mass spectrometry in the field of carotenoid pigments.

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Xanthophyll esters are found in human colostrum

Cited by 30 publications

References 49 publications

Bioaccessibility of carotenoids from plant and animal foods

Bioaccessibility of carotenoids from plant and animal foods

An Overview of Carotenoids, Apocarotenoids, and Vitamin A in Agro‐Food, Nutrition, Health, and Disease

Recent Developments in the Analysis of Carotenoids by Mass Spectrometry

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