Paper-based microfluidic devices on the crime scene: A simple tool for rapid estimation of post-mortem interval using vitreous humour

Garcia, Paulo de Tarso; Gabriel, Ellen Flávia Moreira; Pessôa, Gustavo de Souza; Júnior, Júlio César Santos; Filho, Pedro Carlos Mollo; Guidugli, Ruggero Bernardo; Höehr, Nelci Fenalti; Arruda, Marco Aurélio Zezzi; Coltro, Wendell K. T.

doi:10.1016/j.aca.2017.04.040

Cited by 39 publications

(15 citation statements)

References 28 publications

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“…In recent years, forensic chemistry has seen a rise in the development of portable and inexpensive platforms for different applications including determining the post‐mortem interval , detecting drugs of abuse , explosives , estimating quality control and food safety , evaluating inks and questioned documents (like signatures, rubrics or banknotes, for example) , assessing the authenticity of alcoholic beverages like whiskey and differentiation of beers . Using portable platforms may enable rapid screening at the point‐of‐need without sophisticated instrumentation or extensive training.…”

Section: Introductionmentioning

confidence: 99%

Detection of Analgesics and Sedation Drugs in Whiskey Using Electrochemical Paper‐based Analytical Devices

et al. 2018

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The adulteration of whiskey with analgesics and sedation drugs has been a common practice to prevent hangover the following day and promote loss of consciousness. In both situations, the portable and low cost detection platforms are of paramount importance for forensic investigations. This report describes the use of electrochemical paper‐based analytical devices (ePADs) fabricated by pencil drawing for detecting metamizole, paracetamol and midazolam maleate in whiskey. Different types of paper substrates and graphite pencils were initially characterized with ferrocyanide. The best results were achieved using vegetal paper and Aquarelle/6B pencils. ePADs revealed a decrease in current signal indicating a short lifetime, thus limiting their use to disposable sensors. Despite the short lifetime, the graphite pencil ePADs revealed good electrochemical reproducibility (RSD=3.3 %). The forensic feasibility of the proposed ePADs was demonstrated through the analysis of metamizole and paracetamol in whiskey. The limit of detection (LOD) achieved for paracetamol and metamizole were 45 and 20 mg L−1, respectively. ePADs were also tested to detect midazolam maleate in whiskey. The signal recorded exhibited linear correlation in a wide concentration range (25–1000 mg L−1) and a LOD of ca. 5 mg L−1. Considering the disposability and operational simplicity, ePADs offer a good strategy for detecting adulterations in alcoholic beverages at the point‐of‐need.

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Section: Introductionmentioning

confidence: 99%

Detection of Analgesics and Sedation Drugs in Whiskey Using Electrochemical Paper‐based Analytical Devices

et al. 2018

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“…Paper electrodes, also called electrochemical paper-based analytical devices (ePADs) or paper-based electrochemical devices (PEDs), have been successfully applied in pharmaceutical, biological, food, and environmental analysis (9,(16)(17)(18)(19)(20)(21)(22)(23)(24). Also, in forensic analysis they have been employed to analyze analgesics and sedatives in whiskeys (25).…”

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confidence: 99%

Development of a Pencil Drawn Paper‐based Analytical Device to Detect Lysergic Acid Diethylamide (LSD)*†

Ribeiro

Bento

Ipólito

et al. 2020

Journal of Forensic Sciences

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The need for agile and proper identification of drugs of abuse has encouraged the scientific community to improve and to develop new methodologies. The drug lysergic acid diethylamide (LSD) is still widely used due to its hallucinogenic effects. The use of voltammetric methods to analyze narcotics has increased in recent years, and the possibility of miniaturizing the electrochemical equipment allows these methods to be applied outside the laboratory; for example, in crime scenes. In addition to portability, the search for affordable and sustainable materials for use in electroanalytical research has grown in recent decades. In this context, employing paper substrate, graphite pencil, and silver paint to construct paper-based electrodes is a great alternative. Here, a paper-based device comprising three electrodes was drawn on 300 g/m 2 watercolor paper with 8B pencils, and its efficiency was compared to the efficiency of a commercially available screen-printed carbon electrode. Square wave voltammetry was used for LSD analysis in aqueous medium containing 0.05 mol/L LiClO 4. The limits of detection and quantification were 0.38 and 1.27 μmol/L, respectively. Both electrodes exhibited a similar voltammetric response, which was also confirmed during analysis of a seized LSD sample, with recovery of less than 10%. The seized samples were previously analyzed by GCMS technique, employing the full scan spectra against the software spectral library. The electrode selectivity was also tested against 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine. It was possible to differentiate these compounds from LSD, indicating that the developed paper-based device has potential application in forensic chemistry analyses.

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“…The quartz lter paper, xerox printing paper, tissue paper and normal lter paper were found to be unsuitable since the very large pore size on their surface led to incomplete trapping of the analytes within the bres of the paper due to rapid spreading of the liquid, resulting in broad spectral interference during the FTIR analysis. [35][36][37][38] The results are shown in Fig. 3A(a-f).…”

Section: Resultsmentioning

confidence: 96%

A KBr-impregnated paper substrate as a sample probe for the enhanced ATR-FTIR signal strength of anionic and non-ionic surfactants in an aqueous medium

et al. 2020

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Paper-based microfluidic devices on the crime scene: A simple tool for rapid estimation of post-mortem interval using vitreous humour

Cited by 39 publications

References 28 publications

Detection of Analgesics and Sedation Drugs in Whiskey Using Electrochemical Paper‐based Analytical Devices

Detection of Analgesics and Sedation Drugs in Whiskey Using Electrochemical Paper‐based Analytical Devices

Development of a Pencil Drawn Paper‐based Analytical Device to Detect Lysergic Acid Diethylamide (LSD)*†

A KBr-impregnated paper substrate as a sample probe for the enhanced ATR-FTIR signal strength of anionic and non-ionic surfactants in an aqueous medium

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