The Identity of “Chromium Malate”

Abstract

Recently, several studies on the effects of a compound named "chromium malate," with the proposed formula "Crmalate·xHO" where x = 3.5 or 5, on the health of healthy and diabetic rats have appeared. However, the compound is poorly characterized, and knowing the identity of this material could be important in the interpretation of the previous and of future studies on the effects of this compound in animals. Consequently, the synthesis, characterization, and identity of this material were explored. A combination of spectroscopic, magnetic, and elemental analyses and mass spectral studies reveal that the compound is probably a polymer, not a discrete molecule, and does not have the composition previously reported. The repeating unit of the polymer possesses an antiferromagnetically coupled trinuclear Cr(III) core. The current study suggests that previous reports on chromium malate and its effects in animals must be viewed with caution.

Pharmacokinetics and bioavailability of chromium malate and its influence on trace metals absorption after oral or intravenous administration

“…[ 5 ] Cr 3+ have been widely used as supplements to treat glucose intolerance and insulin resistance. [ 6 7 ] Studies show that Cr 3+ and Cr 3+ complex can significantly reduce fasting blood glucose (FBG) level, enhance insulin sensitivity, and regulate lipid metabolism. [ 8 9 ] However, there have studies showed that chromium salt can endanger human health when exposed to the environment.…”